Effect of Long-term Use of Steroidal Anti-inflammatory Drugs on the Periodontal State: A Review

Corticosteroids are chemically similar to endogenous cortisol and mostly prescribed for their anti-inflammatory and immunosuppressive properties, which are due to the inhibition of phospholipase A2 activity. These drugs are extensively used in the treatment of a plethora of autoimmune disorders such as rheumatoid arthritis, various breathing disorders and also disorders of connective tissue. In the field of dentistry these drugs are prescribed in most of the mucocutaneous disorders such as they are mostly used in inflammatory diseases such as oral lichen planus, pemphigus, and oral stomatitis to alleviate postoperative discomfort and swelling. These drugs can be administered systemically,topically or asinhalational therapy. Evidence concludes that short term corticosteroids possess antiresorptive properties and its local application shows a favourable effect on the periodontal ligament, but when administered systemically for a long period could lead to periodontal diseases as it has shown to increase attachment with alveolar bone and destruction of transseptalfibers. Oral manifestations are dependent on duration,dose and frequency of use. It is commonly associated withmoniliasis, dental caries,altered taste sensation, ulceration of the tongue, buccal mucosa, and gingiva due to xerostomia,gingival inflammation, periodontal inflammation,and immune suppression. They can either cause dramatic improvement or dramatic adverse reactions which can lead to a considerable increase in the distributionof periodontal disorders. In patients on long-term corticosteroid therapy, oral health is generally not given importance during management. Hence this review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

• Publication year

  2020

• Venue

  Indian Journal of Forensic Medicine & Toxicology

• Publication date

  2020-10-07

• Fields of study

  Not labeled

• Identifiers
  DOI 10.37506/ijfmt.v14i4.12955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• OSTEOPOROTIC FRACTURE RISK IN RHEUMATOID ARTHRITIS

  2018cited by this paper
• CORTICOSTEROIDS - ASSETS AND LIABILITIES ON PERIODONTIUM

  2018cited by this paper
• Clinical and radiological assessment of effects of long-term corticosteroid therapy on oral health

  2013cited by this paper
• Effect of Inhaled Medication and Inhalation Technique on Dental Caries in Asthmatic Patients

  2012cited by this paper
• Topical corticosteroids, structure-activity and the glucocorticoid receptor: discovery and development--a process of "planned serendipity".

  2008cited by this paper
• Current concepts in the treatment of recurrent aphthous stomatitis.

  2008cited by this paper
• Drug Insight: selective agonists and antagonists of the glucocorticoid receptor

  2008cited by this paper
• Steroid Therapy - Current Indications in Practice

  2007cited by this paper
• Update on glucocorticoid action and resistance.

  2006cited by this paper
• The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis

  2005cited by this paper
• Steroid cover for dental patients on long-term steroid medication: proposed clinical guidelines based upon a critical review of the literature

  2004cited by this paper
• Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus.

  2002cited by this paper
• Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution.

  2002cited by this paper
• Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease.

  2002cited by this paper
• A review of perioperative corticosteroid use in dentoalveolar surgery.

  2000cited by this paper
• Topical corticosteroids: An update

  2000cited by this paper
• WHO Model Prescribing Information — Drugs Used in Skin Diseases

  1999cited by this paper
• Risk for periodontal disease in patients with longstanding rheumatoid arthritis.

  1997cited by this paper
• Double-blind clinical trial of 0.05% clobetasol proprionate ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases

  1994cited by this paper
• Topical Corticosteroids and Unwanted Local Effects

  1994cited by this paper
• Dexamethasone reduces pain and swelling following extraction of third molar teeth

  1993cited by this paper
• Fluocinonide in an adhesive base for treatment of oral lichen planus. A double-blind, placebo-controlled clinical study.

  1993cited by this paper
• Periodontal alterations in patients with pemphigus vulgaris taking steroids. A biannual assessment.

  1990cited by this paper
• Drugs and the periodontium.

  1988cited by this paper
• Corticosteroid therapy and periodontal disease.

  1984cited by this paper
• Effects of corticosteroids on the proliferation of normal and abnormal human connective tissue cells

  1980cited by this paper
• [Corticosteroids in dentistry].

  1967cited by this paper

• No citing papers are available for this paper.