Imidazoline antagonists of alpha 2-adrenoceptors increase insulin release in vitro by inhibiting ATP-sensitive K+ channels in pancreatic beta-cells.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  British Journal of Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 1358388PMCID PMC1907631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1991cited by this paper
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  1991cited by this paper
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• Clonidine inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells.

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  1990cited by this paper
• Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels.

  1990cited by this paper
• Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells

  1990cited by this paper
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  1990cited by this paper
• Are there multiple imidazoline binding sites?

  1989cited by this paper
• Effects of putative activators of K+ channels in mouse pancreatic beta-cells.

  1989cited by this paper
• An insulin-releasing property of imidazoline derivatives is not limited to compounds that block α-adrenoceptors

  1989cited by this paper
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  1988cited by this paper
• Highly potent and stereoselective effects of the benzoic acid derivative AZ‐DF 265 on pancreatic β‐cells

  1988cited by this paper
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  1988cited by this paper
• Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release

  1988cited by this paper
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  1988cited by this paper
• Alpha-adrenergic blockade improves glucose-potentiated insulin secretion in non-insulin-dependent diabetes mellitus.

  1987cited by this paper
• Studies of Midaglizole (DG-5128): A New Type of Oral Hypoglycemic Drug in Healthy Subjects

  1987cited by this paper
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  1986cited by this paper
• A metabolite-regulated potassium channel in rat pancreatic B cells.

  1986cited by this paper
• Glucose dependent K+-channels in pancreaticβ-cells are regulated by intracellular ATP

  1985cited by this paper
• Effects of alpha-adrenoceptor blockade by phentolamine on basal and stimulated insulin secretion in the mouse.

  1985cited by this paper
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• Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells.

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• α2-Adrenoceptors modulating insulin release from isolated pancreatic islets

  1980cited by this paper
• D-Glucose inhibits potassium efflux from pancreatic islet cells

  1978cited by this paper
• A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus.

  1976cited by this paper
• Effect of phentolamine and preperfusion with glucose on insulin release from the isolated perfused pancreas from fasted and fed rats

  1975cited by this paper
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  1972cited by this paper
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  1970cited by this paper
• Role of adrenergic receptors in glucose-induced insulin secretion in man.

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  2010influential citation
• Effects of imidazoline compounds on cytoplasmic Ca2+ concentration and ATP-sensitive K+ channels in pancreatic B-cells.

  2009cites this paper
• α2A‐Adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice

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• Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion

  2007cites this paper
• Isolated islets in diabetes research.

  2007cites this paper
• Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels.

  2007cites this paper
• Pharmacology of the K‐ATP Channel Blocking Morpholinoguanidine PNU‐37883A

  2006cites this paper
• Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.

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• Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes.

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• Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R

  2005cites this paper
• Induction of pancreatic duct cells of neonatal rats into insulin-producing cells with fetal bovine serum: a natural protocol and its use for patch clamp experiments.

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• Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues.

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.

  2003cites this paper
• Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

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• The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets

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• Imidazoline NNC77-0074 stimulates Ca2+-evoked exocytosis in INS-1E cells by a phospholipase A2-dependent mechanism.

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• Desensitization of insulin secretion.

  2002cites this paper
• Identification of the monomeric G‐protein, Rhes, as an efaroxan‐regulated protein in the pancreatic β‐cell

  2002cites this paper
• Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

  2001cites this paper
• Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies.

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• Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets.

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  1996cites this paper
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  1996influential citation
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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• Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.

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• Characterization of the Imidazoline Binding Site Involved in Regulation of Insulin Secretion fn1

  1995cites this paper
• The Relationship between the Adrenoceptor and Nonadrenoceptor‐Mediated Effects of Imidazoline‐ and Imidazole‐Containing Compounds fn1

  1995cites this paper
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  1995cites this paper
• Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites.

  1995cites this paper
• Effects of imidazoline antagonists of alpha 2-adrenoceptors on endogenous adrenaline-induced inhibition of insulin release.

  1995cites this paper
• The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans.

  1995cites this paper
• No Relationship of I1 and I2 Imidazoline Binding Sites to Inhibitory Effects of Imidazolines on Ligand‐Gated Ion Channels

  1995cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Inhibition by imidazoline and imidazolidine derivatives of glibenclamide-sensitive K+ currents in Xenopus oocytes.

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  1993cites this paper
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