Wilms’ tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Leukemia

• Publication date

  2010-03-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/leu.2010.33PMID 20237505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

  2009cited by this paper
• Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias.

  2009cited by this paper
• The IRF family transcription factors in immunity and oncogenesis.

  2008cited by this paper
• Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia.

  2008cited by this paper
• An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia.

  2008cited by this paper
• Epigenetic disruption of interferon-γ response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas

  2008cited by this paper
• DNA Methylation Represses IFN-γ–Induced and Signal Transducer and Activator of Transcription 1–Mediated IFN Regulatory Factor 8 Activation in Colon Carcinoma Cells

  2008cited by this paper
• Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene.

  2008cited by this paper
• Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.

  2007cited by this paper
• A tumor suppressor and oncogene: the WT1 story

  2007cited by this paper
• The Wilms’ tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis

  2007cited by this paper
• Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells

  2007cited by this paper
• Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR

  2006cited by this paper
• Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.

  2006cited by this paper
• Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor.

  2006cited by this paper
• AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

  2006cited by this paper
• Interferon-γ induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors

  2006cited by this paper
• Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis

  2006cited by this paper
• Prognostically useful gene-expression profiles in acute myeloid leukemia.

  2004cited by this paper
• Clonogenicity, gene expression and phenotype during neutrophil versus erythroid differentiation of cytokine‐stimulated CD34+ human marrow cells in vitro

  2004cited by this paper
• Sensitivity to imatinib therapy may be predicted by testing Wilms tumor gene expression and colony growth after a short in vitro incubation

  2004cited by this paper
• The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.

  2004cited by this paper
• Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2.

  2004cited by this paper
• Role of the WT1 tumor suppressor in murine hematopoiesis.

  2003cited by this paper
• ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells.

  2003cited by this paper
• Very low frequencies of human normal CD34+ haematopoietic progenitor cells express the Wilms' tumour gene WT1 at levels similar to those in leukaemia cells

  2002cited by this paper
• Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream.

  2002cited by this paper
• AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency

  2002cited by this paper
• Interferon consensus sequence binding protein: Not essential for interferon alpha-mediated antiviral response to vesicular-stomatitis virus infection in HL-60 cells

  2001cited by this paper
• Wilms tumor and the WT1 gene.

  2001cited by this paper
• Highly abundant genes in the transcriptosome of human and baboon CD34 antigen-positive bone marrow cells.

  2001cited by this paper
• WT1 proteins: functions in growth and differentiation.

  2001cited by this paper
• Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder

  2000cited by this paper
• Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein.

  2000cited by this paper
• Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).

  1999cited by this paper
• Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

  1998cited by this paper
• Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.

  1998cited by this paper
• Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.

  1998cited by this paper
• Wilms' tumor gene expression in human CD34+ hematopoietic progenitors during fetal development and early clonogenic growth.

  1997cited by this paper
• The Wilms' tumor gene is expressed in a subset of CD34+ progenitors and downregulated early in the course of differentiation in vitro.

  1997cited by this paper
• Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis.

  1997cited by this paper
• A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines.

  1996cited by this paper
• Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.

  1996cited by this paper
• Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow.

  1995cited by this paper
• Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias.

  1995cited by this paper
• WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia.

  1994cited by this paper
• Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells.

  1993cited by this paper
• Expression of the Wilms' tumor gene (WT1) in human leukemias.

  1992cited by this paper

• WT1 together with RUNX1::RUNX1T1 targets DUSP6 to dampen ERK activity in acute myeloid leukaemia

  2024cites this paper
• Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis

  2023cites this paper
• First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience

  2022cites this paper
• Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

  2019cites this paper
• Développement d’un modèle murin syngénique et immun de leucémie aiguë myéloïde et de maladie résiduelle mesurable surexprimant ou non le gène Wilms Tumor 1

  2018cites this paper
• Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination

  2018cites this paper
• DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and −KTS isoforms—From initial observations to recent global genomic analyses

  2018cites this paper
• THE REGULATORY ROLE OF THE TRANSCRIPTION FACTOR ZNF224 IN CHRONIC MYELOGENOUS LEUKEMIA

  2017influential citation
• Distinct global binding patterns of the Wilms tumor gene 1 (WT1) −KTS and +KTS isoforms in leukemic cells

  2017cites this paper
• The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells

  2017cites this paper
• The Complex Role of the ZNF224 Transcription Factor in Cancer.

  2017cites this paper
• the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF 224 , acting as a cofactor of the Wilms ' tumor gene 1 ( WT 1 ) protein

  2017cites this paper
• Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities

  2016cites this paper
• The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.

  2016cites this paper
• Relevance of Interferon Regulatory Factor-8 Expression in Myeloid–Tumor Interactions

  2016cites this paper
• WT1 Gene Overexpression in Oncohematological Disorders: Theoretical and Clinical Aspects (Literature Review)

  2016cites this paper
• Is Wilms’ tumor gene 1 a useful biomarker for detecting minimal residual disease in chronic myeloid leukemia (BCR-ABL1-p210-positive) patients?

  2016cites this paper
• Monitoring of WT1 and its target gene IRF8 expression in acute myeloid leukemia and their significance

  2015cites this paper
• WT1 Expression in Adult Acute Myeloid Leukemia: Assessing its Presence, Magnitude and Temporal Changes as Prognostic Factors

  2015cites this paper
• Regulation of myelopoiesis by the transcription factor IRF8

  2015cites this paper
• WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

  2015cites this paper
• Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes

  2014cites this paper
• Wt1 regulates the expression of inhibitory chemokines during heart development

  2014cites this paper
• Regulation of the Interferon regulatory factor-8 (IRF-8) Tumor Suppressor Gene by the Signal Transducer and Activator of Transcription 5 (STAT5) Transcription Factor in Chronic Myeloid Leukemia*

  2014cites this paper
• Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis.

  2014cites this paper
• WT1 regulates the expression of inhibitory chemokines during heart development.

  2013cites this paper
• Interferon Regulatory Factor-8 Is Important for Histone Deacetylase Inhibitor-Mediated Antitumor Activity

  2012cites this paper
• DYSREGULATION OF MEOX2 FOLLOWING WT1 MUTATION IN KIDNEY DEVELOPMENT AND WILMS TUMORIGENESIS

  2011cites this paper
• Mechanisms of leukemogenesis by MLL fusion proteins

  2011influential citation
• WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

  2010cites this paper
• AN EFFECTOR IN LEUKEMOGENESIS

  2010cites this paper