Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  International Journal of Oncology

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijo.2011.1114PMID 21743962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

  2009cited by this paper
• Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines.

  2009cited by this paper
• Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression.

  2009cited by this paper
• Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.

  2009cited by this paper
• Two Novel Functions of Hyaluronidase-2 (Hyal2) Are Formation of the Glycocalyx and Control of CD44-ERM Interactions*

  2009cited by this paper
• Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.

  2008cited by this paper
• HYAL1 and HYAL2 Inhibit Tumour Growth In Vivo but Not In Vitro

  2008cited by this paper
• Adhesion proteins meet receptors: a common theme?

  2008cited by this paper
• Altered hyaluronan biosynthesis in cancer progression.

  2008cited by this paper
• Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4

  2008cited by this paper
• Hyalurondiase: both a tumor promoter and suppressor.

  2008cited by this paper
• Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.

  2008cited by this paper
• CD44-dependent Intracellular and Extracellular Catabolism of Hyaluronic Acid by Hyaluronidase-1 and -2*

  2007influential reference
• Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

  2007influential reference
• Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis*

  2007cited by this paper
• In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.

  2007cited by this paper
• Depolymerized Hyaluronan Induces Vascular Endothelial Growth Factor, a Negative Regulator of Developmental Epithelial-to-Mesenchymal Transformation

  2006cited by this paper
• The Human Hyaluronan Synthase 2 Gene Is a Primary Retinoic Acid and Epidermal Growth Factor Responding Gene*

  2005cited by this paper
• Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells

  2005cited by this paper
• CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells.

  2005cited by this paper
• The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer.

  2005influential reference
• Fibroblast growth factor‐2 regulates the synthesis of hyaluronan by human periodontal ligament cells

  2005cited by this paper
• Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.

  2005cited by this paper
• Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.

  2005cited by this paper
• CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion*

  2004cited by this paper
• CD44 Potentiates the Adherence of Metastatic Prostate and Breast Cancer Cells to Bone Marrow Endothelial Cells

  2004cited by this paper
• Hyaluronan-oligosaccharide-induced transcription of metalloproteases

  2004cited by this paper
• Myofibroblastic Differentiation Leads to Hyaluronan Accumulation through Reduced Hyaluronan Turnover*

  2004cited by this paper
• Hyaluronan: from extracellular glue to pericellular cue

  2004cited by this paper
• Devising a pathway for hyaluronan catabolism: are we there yet?

  2003cited by this paper
• Selective Expression and Functional Characteristics of Three Mammalian Hyaluronan Synthases in Oncogenic Malignant Transformation*

  2003cited by this paper
• Elevated Hyaluronan Production Induces Mesenchymal and Transformed Properties in Epithelial Cells*

  2003cited by this paper
• Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-expressing Tumor Cells*

  2003cited by this paper
• Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer.

  2003cited by this paper
• Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors

  2002cited by this paper
• CD44 is required for two consecutive steps in HGF/c-Met signaling.

  2002cited by this paper
• CD44 in Cancer

  2002cited by this paper
• Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice.

  2002cited by this paper
• CD44 signaling through focal adhesion kinase and its anti‐apoptotic effect

  2002influential reference
• Signaling Properties of Hyaluronan Receptors*

  2002cited by this paper
• CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling.

  2002cited by this paper
• Prognostic value of hyaluronan expression in non‐small‐cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma

  2001cited by this paper
• Group A Streptococcus tissue invasion by CD44-mediated cell signalling

  2001cited by this paper
• Epidermal Growth Factor Activates Hyaluronan Synthase 2 in Epidermal Keratinocytes and Increases Pericellular and Intracellular Hyaluronan*

  2001cited by this paper
• Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

  2001cited by this paper
• Stromal and Epithelial Expression of Tumor Markers Hyaluronic Acid and HYAL1 Hyaluronidase in Prostate Cancer*

  2001cited by this paper
• The six hyaluronidase-like genes in the human and mouse genomes.

  2001cited by this paper
• High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer.

  2001cited by this paper
• Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells.

  2000cited by this paper
• Activation of mitogen-activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells.

  2000cited by this paper
• Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.

  2000cited by this paper
• Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival.

  2000cited by this paper
• Abrogation of Experimental Colitis Correlates with Increased Apoptosis in Mice Deficient for Cd44 Variant Exon 7 (Cd44v7)

  2000cited by this paper
• CD44 Interaction with Tiam1 Promotes Rac1 Signaling and Hyaluronic Acid-mediated Breast Tumor Cell Migration*

  2000cited by this paper
• Hyaluronic Acid (Ha) Binding to Cd44 Activates Rac1 and Induces Lamellipodia Outgrowth

  2000cited by this paper
• High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer.

  2000cited by this paper
• Ras, Protein Kinase Cζ, and IκB Kinases 1 and 2 Are Downstream Effectors of CD44 During the Activation of NF-κB by Hyaluronic Acid Fragments in T-24 Carcinoma Cells1

  2000cited by this paper
• Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.

  1999cited by this paper
• Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.

  1999cited by this paper
• Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.

  1999cited by this paper
• Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*

  1999cited by this paper
• Crosslinking of CD44 on rheumatoid synovial cells augment interleukin 6 production.

  1999cited by this paper
• CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.

  1999cited by this paper
• Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.

  1999cited by this paper
• Adhesion proteins in the biology of breast cancer: contribution of CD44.

  1999cited by this paper
• HYAL2, a Human Gene Expressed in Many Cells, Encodes a Lysosomal Hyaluronidase with a Novel Type of Specificity*

  1998cited by this paper
• Interaction between the Adhesion Receptor, CD44, and the Oncogene Product, p185 HER2 , Promotes Human Ovarian Tumor Cell Activation*

  1997cited by this paper
• Tumor-associated hyaluronic acid: a new sensitive and specific urine marker for bladder cancer.

  1997cited by this paper
• Hyaluronan synthases.

  1997cited by this paper
• Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: identification as an NH2-terminal fragment of human fibronectin.

  1997cited by this paper
• Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.

  1996cited by this paper
• CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis.

  1995cited by this paper
• Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

  1993cited by this paper
• CD44H regulates tumor cell migration on hyaluronate-coated substrate

  1992cited by this paper
• LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release.

  1990cited by this paper
• Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill.

  1989cited by this paper
• A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity.

  1987cited by this paper
• Tumor cell autocrine motility factor.

  1986cited by this paper
• The selective suppression of immunogenicity by hyaluronic acid.

  1986cited by this paper
• Angiogenesis induced by degradation products of hyaluronic acid.

  1985cited by this paper
• Hyaluronate in vasculogenesis.

  1983cited by this paper
• Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis

  1979cited by this paper

• The association between blood-based HYAL2 methylation and early-stage lung cancer: a case-control study

  2025cites this paper
• Effects of Radiation-Induced Skin Injury on Hyaluronan Degradation and Its Underlying Mechanisms

  2023cites this paper
• ‘Two-faces’ of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment

  2023influential citation
• Hyaluronan Metabolism and Tumor Progression

  2022cites this paper
• The Association Between Breast Cancer and Blood-Based Methylation of S100P and HYAL2 in the Chinese Population

  2020cites this paper
• Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System

  2020cites this paper
• Molecular organization and mechanical properties of the hyaluronan matrix surrounding the mammalian oocyte.

  2018cites this paper
• HYAL2 methylation in peripheral blood as a potential marker for the detection of pancreatic cancer: a case control study

  2017cites this paper
• HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response

  2016cites this paper
• Lipid Raft-Mediated Regulation of Hyaluronan–CD44 Interactions in Inflammation and Cancer

  2015cites this paper
• S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer.

  2015cites this paper
• Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms.

  2015cites this paper
• Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.

  2015cites this paper
• DNA methylation array analyses identified breast cancer‐associated HYAL2 methylation in peripheral blood

  2015cites this paper
• Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis

  2014cites this paper
• Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors.

  2014cites this paper
• Sugars in the microenvironment: the sticky problem of HA turnover in tumors

  2014cites this paper
• Emerging roles for hyaluronidase in cancer metastasis and therapy.

  2014cites this paper
• 4-methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells.

  2013cites this paper
• Critical role of hyaluronidase-2 during preimplantation embryo development.

  2013cites this paper
• The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells

  2013cites this paper
• Methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells

  year unknowncites this paper