Renal collecting duct plasticity revealed by intercalated cell lineage tracing

The connecting tubule and collecting duct in the distal nephron play an essential role for acid‐base and NaCl homeostasis. Their epithelium comprises two main cell types, i.e. principal cells and intercalated cells (IC). At least two types of IC, type A‐IC and type B‐IC are distinguished. While A‐IC express the V‐type ATPase at their apical side, it localizes basolaterally in B‐IC. Thus, A‐IC can actively secrete H+, while B‐IC can mediate bicarbonate secretion via apical pendrin. Adaptation to a change in acid/base status is partly achieved by varying the numbers of A‐IC and B‐IC cells. For example, a chronic metabolic acidosis or LiCl administration promote an increase in A‐IC while the number of B‐IC is decreased. Based on these findings it is assumed that the plasticity of the distal nephron might be explained in part by a conversion of B‐IC into A‐IC or principal cell to A‐IC or vice versa.

• Publication year

  2019

• Venue

  The FASEB Journal

• Publication date

  2019-04-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1096/fasebj.2019.33.1_supplement.544.11
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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