The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates

Objective: This study aimed to assess the impact of hyperbilirubinemia and Intensive phototherapy on apaptosis in peripheral blood of preterm infants. Patients and Method: The study was conducted on 18 preterm infants with non-hemolytic hyperbilirubinemia and 9 control healthy preterm infants. Apaptosismarkers (anti-apoptotic protein Bcl2, and pro-apoptotic protein BAX) was assessed using ELISA technique. Blood samples wereobtained at enrollment in all infants and after24 hours of exposure to intensive phototherapy in jaundiced infants. Result: Before phototherapy, no significant difference in the serum levels of bcl2 and Bax protein between jaundiced and non-jaundiced preterm infants (P = 0.570, p= 0.329 respectively), After phototherapy The serum levels of Bcl2 decrease while The serum levels of BAX increased significantly (P=0.003, p<0.001 respectively). Conclusion: Hyperbilirubinemia does not influence apaptosis whereas intensive phototherapy do in preterm infants with hyperbilirubinemia.

• Publication year

  2020

• Venue

  Indian Journal of Public Health Research & Development

• Publication date

  2020-05-24

• Fields of study

  Not labeled

• Identifiers
  DOI 10.37506/ijphrd.v11i5.9419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells

  2018cited by this paper
• Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

  2017cited by this paper
• Programmed cell death and the immune system

  2017cited by this paper
• Lower nucleotide excision repair capacity in newborns compared to their mothers: a pilot study.

  2014cited by this paper
• Bax protein may influence the invasion of colorectal cancer.

  2014cited by this paper
• DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

  2013cited by this paper
• Micronucleated erythrocytes in preterm newborns exposed to phototherapy and/or oxygentherapy.

  2012cited by this paper
• Assessment of DNA damage and plasma catalase activity in healthy term hyperbilirubinemic infants receiving phototherapy.

  2009cited by this paper
• The micronucleus assay determination of chromosomal level DNA damage.

  2008cited by this paper
• DNA damage-induced cell death by apoptosis.

  2006cited by this paper
• Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease.

  2002influential reference
• A simple method for accurate estimation of apoptotic cells.

  2000cited by this paper
• THE PRECARIOUS ANTIOXIDANT DEFENSES OF THE PRETERM INFANT

  2000cited by this paper

• No citing papers are available for this paper.