Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010)

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2015-06-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/AAC.00683-15PMID 26055366PMCID PMC4538548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Up-date on diagnostic strategies of invasive aspergillosis.

  2013cited by this paper
• Receptor-mediated signaling in Aspergillus fumigatus

  2013cited by this paper
• Hidden Killers: Human Fungal Infections

  2012cited by this paper
• Role of Innate Immune Receptors in Paradoxical Caspofungin Activity In Vivo in Preclinical Aspergillosis

  2012cited by this paper
• A New Approach to Drug Discovery

  2012influential reference
• Prophylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin - review of the literature

  2011cited by this paper
• Anti‐HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP‐dependent enzyme activities

  2011cited by this paper
• The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus

  2011cited by this paper
• Regulation of multidrug resistance in pathogenic fungi.

  2010cited by this paper
• AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus.

  2010cited by this paper
• The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.

  2009cited by this paper
• Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

  2008cited by this paper
• Modulation of Yeast Sln1 Kinase Activity by the Ccw12 Cell Wall Protein*

  2008cited by this paper
• Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway

  2008cited by this paper
• Two-Component Signal Transduction Proteins as Potential Drug Targets in Medically Important Fungi

  2008cited by this paper
• EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds.

  2008cited by this paper
• The Aspergillus fumigatus Transcriptional Regulator AfYap1 Represents the Major Regulator for Defense against Reactive Oxygen Intermediates but Is Dispensable for Pathogenicity in an Intranasal Mouse Infection Model

  2007cited by this paper
• Attenuation of echinocandin activity at elevated concentrations: a review of the paradoxical effect

  2007cited by this paper
• Characterization of the SKN7 ortholog of Aspergillus fumigatus.

  2007cited by this paper
• Siamycin Attenuates fsr Quorum Sensing Mediated by a Gelatinase Biosynthesis-Activating Pheromone in Enterococcus faecalis

  2006cited by this paper
• The akuBKU80 Mutant Deficient for Nonhomologous End Joining Is a Powerful Tool for Analyzing Pathogenicity in Aspergillus fumigatus

  2006cited by this paper
• The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus.

  2006cited by this paper
• Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development.

  2006cited by this paper
• Synergy Tests by E Test and Checkerboard Methods of Antimicrobial Combinations against Brucella melitensis

  2005cited by this paper
• In vitro antitumor structure-activity relationships of threo/trans/threo/trans/erythro bis-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I.

  2005cited by this paper
• Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants.

  2005cited by this paper
• Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin.

  2005cited by this paper
• Caspofungin.

  2003cited by this paper
• Flow Cytometry Antifungal Susceptibility Testing of Aspergillus fumigatus and Comparison of Mode of Action of Voriconazole vis-à-vis Amphotericin B and Itraconazole

  2003cited by this paper
• In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I.

  2003cited by this paper
• The Antifungal Echinocandin Caspofungin Acetate Kills Growing Cells of Aspergillus fumigatus In Vitro

  2002cited by this paper
• Potent Synergism of the Combination of Fluconazole and Cyclosporine in Candida albicans

  2000cited by this paper
• Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence

  1997cited by this paper
• Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.

  1996cited by this paper
• Selection of multiple disruption events in Aspergillus fumigatus using the orotidine-5′-decarboxylase gene, pyrG, as a unique transformation marker

  1996cited by this paper
• High-resolution solution structure of siamycin II: Novel amphipathic character of a 21-residue peptide that inhibits HIV fusion

  1995cited by this paper
• Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.

  1995cited by this paper
• Siamycins I and II, new anti-HIV peptides: I. Fermentation, isolation, biological activity and initial characterization.

  1995influential reference
• Yeast Skn7p functions in a eukaryotic two‐component regulatory pathway.

  1994cited by this paper
• Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus.

  1994cited by this paper

• Lasso Peptides—A New Weapon Against Superbugs

  2025cites this paper
• Lasso peptides: A focus on therapeutic index

  2025influential citation
• The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide.

  2024cites this paper
• Advances in lasso peptide discovery, biosynthesis, and function.

  2024cites this paper
• Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.

  2024cites this paper
• Opportunities and challenges of RiPP-based therapeutics.

  2024cites this paper
• A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

  2023cites this paper
• Comparative genomics of Bacillus cereus sensu lato spp. biocontrol strains in correlation to in-vitro phenotypes and plant pathogen antagonistic capacity

  2023cites this paper
• Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides.

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
• The high osmolarity glycerol (HOG) pathway in fungi†

  2021cites this paper
• Streptomyces griseocarneus R132 expresses antimicrobial genes and produces metabolites that modulate Galleria mellonella immune system

  2021cites this paper
• Antimicrobial peptides from Actinobacteria: Current status and future prospects

  2021cites this paper
• Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator

  2020cites this paper
• Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin

  2020cites this paper
• How to harness biosynthetic gene clusters of lasso peptides

  2020cites this paper
• Lasso Peptides: Heterologous Production and Potential Medical Application

  2020influential citation
• Novel Antifungal Agents and Their Activity against Aspergillus Species

  2020cites this paper
• Aspergillus fumigatus High Osmolarity Glycerol Mitogen Activated Protein Kinases SakA and MpkC Physically Interact During Osmotic and Cell Wall Stresses

  2019cites this paper
• GEO2RNAseq: An easy-to-use R pipeline for complete pre-processing of RNA-seq data

  2019influential citation
• Molecular characterization of the light response in Alternaria alternata

  2019cites this paper
• Role of the fungus-specific flavin carrier Flc1 in antifungal resistance in the fungal pathogen Cryptococcus neoformans.

  2018cites this paper
• Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

  2018cites this paper
• Genome‐wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1 and MpkC dependent

  2017influential citation
• Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance

  2017cites this paper
• The anti-Aspergillus drug pipeline: Is the glass half full or empty?

  2017cites this paper
• Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis.

  2017cites this paper
• New developments and directions in the clinical application of the echinocandins

  2017cites this paper
• The antifungal pipeline: a reality check

  2017cites this paper
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  2017cites this paper
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  2016influential citation
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  2016cites this paper
• Lasso peptide, a highly stable structure and designable multifunctional backbone

  2016cites this paper
• Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.

  2016cites this paper
• Transcriptomic Crosstalk between Fungal Invasive Pathogens and Their Host Cells: Opportunities and Challenges for Next-Generation Sequencing Methods

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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