Identification of the Missing trans-Acting Enoyl Reductase Required for Phthiocerol Dimycocerosate and Phenolglycolipid Biosynthesis in Mycobacterium tuberculosis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Bacteriology

• Publication date

  2007-04-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JB.00169-07PMID 17468241PMCID PMC1913427
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis

  2007cited by this paper
• The α-aminoadipate pathway for lysine biosynthesis in fungi

  2006cited by this paper
• The alpha-aminoadipate pathway for lysine biosynthesis in fungi.

  2006cited by this paper
• Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-Å resolution

  2006cited by this paper
• Myxovirescin A Biosynthesis is Directed by Hybrid Polyketide Synthases/Nonribosomal Peptide Synthetase, 3‐Hydroxy‐3‐Methylglutaryl–CoA Synthases, and trans‐Acting Acyltransferases

  2006cited by this paper
• Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.

  2005influential reference
• The HHpred interactive server for protein homology detection and structure prediction

  2005cited by this paper
• The dimycocerosate ester polyketide virulence factors of mycobacteria.

  2005cited by this paper
• A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

  2004cited by this paper
• Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae

  2004cited by this paper
• Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily.

  2003cited by this paper
• Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

  2003influential reference
• Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases.

  2003influential reference
• Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

  2003cited by this paper
• The methyl-branched fortifications of Mycobacterium tuberculosis.

  2002cited by this paper
• Short-chain dehydrogenases/reductases (SDRs).

  2002cited by this paper
• Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.

  2002cited by this paper
• Genomic Sequence and Transcriptional Analysis of a 23-Kilobase Mycobacterial Linear Plasmid: Evidence for Horizontal Transfer and Identification of Plasmid Maintenance Systems

  2001cited by this paper
• Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier.

  2001cited by this paper
• Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.

  2000cited by this paper
• The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.

  1999cited by this paper
• Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

  1999cited by this paper
• Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis.

  1999cited by this paper
• Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

  1999cited by this paper
• Isolation of genomic DNA from mycobacteria.

  1998cited by this paper
• The envelope layers of mycobacteria with reference to their pathogenicity.

  1998cited by this paper
• Biochemistry and molecular genetics of cell‐wall lipid biosynthesis in mycobacteria

  1997cited by this paper
• Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.

  1997cited by this paper
• Gene Knockout Reveals a Novel Gene Cluster for the Synthesis of a Class of Cell Wall Lipids Unique to Pathogenic Mycobacteria*

  1997cited by this paper
• New use of BCG for recombinant vaccines

  1991cited by this paper
• Permeability barrier to hydrophilic solutes in Mycobacterium chelonei

  1990cited by this paper
• Scalar, dipolar-correlated and J-resolved 2D-NMR spectroscopy of the specific phenolic mycoside of Mycobacterium tuberculosis.

  1989cited by this paper
• Distribution of phthiocerol diester, phenolic mycosides and related compounds in mycobacteria.

  1988cited by this paper
• Lipids of Putative Relevance to Virulence in Mycobacterium tuberculosis: Correlation of Virulence with Elaboration of Sulfatides and Strongly Acidic Lipids

  1974cited by this paper

• Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies

  2024cites this paper
• Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase Polyketide Synthases

  2023cites this paper
• Roles for phthiocerol dimycocerosate lipids in Mycobacterium tuberculosis pathogenesis.

  2021cites this paper
• Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis

  2019cites this paper
• Rôle et mécanismes moléculaires d'action des lipides de l'enveloppe de Mycobacterium tuberculosis dans la virulence

  2018cites this paper
• Polyketides and Polyketide-Containing Glycolipids ofMycobacterium tuberculosis: Structure, Biosynthesis and Biological Activities

  2017cites this paper
• ESX‐1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

  2017cites this paper
• Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.

  2017cites this paper
• Virulence Factors and Pathogenicity of Mycobacterium

  2017cites this paper
• Characterization of phthiocerol and phthiodiolone dimycocerosate esters of M. tuberculosis by multiple-stage linear ion-trap MS[S]

  2016cites this paper
• The role of horizontal gene transfer in mycobacterial pathogenesis

  2016cites this paper
• Building a better bacillus: the emergence of Mycobacterium tuberculosis

  2014cites this paper
• Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.

  2014cites this paper
• Biosynthesis of mycobacterial lipids by polyketide synthases and beyond

  2014cites this paper
• Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids

  2014cites this paper
• Regio‐selectively reduced streptogramin A analogue, 5,6‐dihydrovirginiamycin M1 exhibits improved potency against MRSA

  2013cites this paper
• The evolution of the Mycobacterium tuberculosis proteome in response to the development of drug resistance

  2013cites this paper
• Genetic, biosynthetic and functional versatility of polyketide synthases

  2012cites this paper
• Comparative Genomics of Cell Envelope Components in Mycobacteria

  2011cites this paper
• Fatty acyl-AMP ligases and polyketide synthases are unique enzymes of lipid biosynthetic machinery in Mycobacterium tuberculosis.

  2011cites this paper
• Generation of reduced macrolide analogs by regio-specific biotransformation

  2011cites this paper
• Computational Methods for Identification of Novel Secondary Metabolite Biosynthetic Pathways by Genome Analysis

  2011cites this paper
• Using a Label-free Proteomics Method to Identify Differentially Abundant Proteins in Closely Related Hypo- and Hypervirulent Clinical Mycobacterium tuberculosis Beijing Isolates

  2010cites this paper
• SBSPKS: structure based sequence analysis of polyketide synthases

  2010cites this paper
• Biosynthesis of the mycobacterial cell envelope components

  2010cites this paper
• Defining mycobacteria: Shared and specific genome features for different lifestyles

  2009cites this paper
• Polyketide versatility in the biosynthesis of complex mycobacterial cell wall lipids.

  2009cites this paper
• Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity.

  2009cites this paper
• Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression.

  2009cites this paper
• Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

  2009cites this paper
• Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

  2009cites this paper
• Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

  2009cites this paper
• Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides.

  2008cites this paper
• Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation.

  2008cites this paper
• Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

  2008cites this paper
• Mycobacterial PGL virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation

  2008cites this paper
• Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

  2008cites this paper
• 17 Biosynthesis and Roles of Phenolic Glycolipids and Related Molecules in Mycobacterium tuberculosis

  2008cites this paper
• Versatility of polyketide synthases in generating metabolic diversity.

  2007cites this paper