Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Canadian Journal of Physiology and Pharmacology

• Publication date

  2012-08-09

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1139/y2012-101PMID 22873715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

  2014cited by this paper
• Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats.

  2013cited by this paper
• Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice

  2013cited by this paper
• A novel RB E3 Ubiquitin Ligase (NRBE3) promotes cancer cell proliferation through a regulation loop with RB/E2F1

  2013cited by this paper
• Role of quercetin in vascular physiology.

  2012cited by this paper
• Should we clean up the reputation of "dirty drugs"?

  2012cited by this paper
• Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension

  2011cited by this paper
• Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice

  2010cited by this paper
• Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

  2010cited by this paper
• Deletion of Inducible Nitric Oxide Synthase Provides Cardioprotection in Mice With 2-Kidney, 1-Clip Hypertension

  2009cited by this paper
• Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice.

  2009cited by this paper
• Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.

  2009cited by this paper
• 3,3',4',5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats.

  2009cited by this paper
• The inhibitory effect of quercitrin gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice

  2008cited by this paper
• Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-beta thalassemia.

  2008cited by this paper
• Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology.

  2008cited by this paper
• Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats.

  2007cited by this paper
• Antioxidant and vascular protective activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica.

  2007cited by this paper
• Microcirculatory endothelial dysfunction during endotoxemia--insights into pathophysiology, pathologic mechanisms and clinical relevance.

  2007cited by this paper
• Endothelial Dysfunction and Oxidant Status in Pediatric Patients with Hemoglobin E-β Thalassemia

  2007cited by this paper
• NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91phox*

  2006cited by this paper
• NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox.

  2006cited by this paper
• Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats

  2006cited by this paper
• A Role for Nitric Oxide-Mediated Peroxynitrite Formation in a Model of Endotoxin-Induced Shock

  2006cited by this paper
• Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients

  2006cited by this paper
• Down-regulatory effect of quercitrin gallate on nuclear factor-kappa B-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7.

  2005cited by this paper
• Gene transfer of extracellular superoxide dismutase improves relaxation of aorta after treatment with endotoxin.

  2004cited by this paper
• Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation.

  2003cited by this paper
• Endotoxin impairs endothelium-dependent vasodilation more in the coronary and renal arteries than in other arteries of the rat.

  2003cited by this paper
• Effects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis

  2003cited by this paper
• Protection against lipopolysaccharide‐induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice

  2003cited by this paper
• Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cells.

  2003cited by this paper
• Immune Cells Redox State from Mice with Endotoxin-induced Oxidative Stress. Involvement of NF-κB

  2003cited by this paper
• Different mechanism of LPS‐induced vasodilation in resistance and conductance arteries from SHR and normotensive rats

  2002cited by this paper
• Flavonoids: a review of probable mechanisms of action and potential applications.

  2001cited by this paper
• Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain.

  2001cited by this paper
• Dietary intake and bioavailability of polyphenols.

  2000cited by this paper
• Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.

  2000cited by this paper
• Flavonoids and membrane lipid peroxidation inhibition.

  1999cited by this paper
• Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia.

  1999cited by this paper
• The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock

  1997cited by this paper
• Bioavailability of the dietary antioxidant flavonol quercetin in man.

  1997cited by this paper
• Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide (*)

  1996cited by this paper
• Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide.

  1996cited by this paper
• Downregulation of nitrovasodilator‐induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin‐1β

  1996cited by this paper
• Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.

  1996cited by this paper
• Peroxynitrite‐mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia‐reperfusion injury

  1995cited by this paper
• Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin.

  1995cited by this paper
• Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

  1993cited by this paper
• Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study.

  1993cited by this paper
• Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

  1991cited by this paper
• Endothelium‐derived relaxing and contracting factors

  1989cited by this paper

• Natural products as multi-target therapies for sepsis-induced myocardial dysfunction (Review)

  2026cites this paper
• Enhanced Microencapsulation of Quercetin-Rich Onion (Allium cepa) Peel Extract in Ethyl Cellulose Using a W/O/W Double Emulsion: Optimised Production, Characterisation, and Controlled Release

  2025cites this paper
• Unlocking the power of Quercetin: A guide to its biological activity

  2025cites this paper
• Chemical Constituents of Stinging Nettle (Urtica dioica L.): A Comprehensive Review on Phenolic and Polyphenolic Compounds and Their Bioactivity

  2024cites this paper
• Neoteric Role Of Quercetin In Visual Disorders.

  2023cites this paper
• Quercetin-based Nanoformulation: A Potential Approach for Cancer Treatment.

  2023cites this paper
• Comparative Interaction of Flavonoid Quercetin with Different Tween Surfactants

  2023cites this paper
• Qili Qiangxin (QLQX) capsule as a multi-functional traditional Chinese medicine in treating chronic heart failure (CHF): A review of ingredients, molecular, cellular, and pharmacological mechanisms

  2023cites this paper
• Therapeutic Potential of Quercetin Loaded Nanoparticles: Novel Insights in Alleviating Colitis in an Experimental DSS Induced Colitis Model

  2022cites this paper
• Red onion skin active ingredients, extraction and biological properties for functional food applications.

  2022cites this paper
• Vascular Protective Effect and Its Possible Mechanism of Action on Selected Active Phytocompounds: A Review

  2022cites this paper
• Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.

  2021cites this paper
• Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

  2021cites this paper
• COMPARISON BETWEEN FLOW CYTOMETERIC METHOD AND OTHER METHODS FORRETICULOCYTE COUNT IN DIAGNOSIS OF PHENYLHYDRAZINE-INDUCED HEMOLYTIC ANEMIA

  2021cites this paper
• Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges

  2021cites this paper
• Flavonoids of the Caryophyllaceae

  2021cites this paper
• Flavonoids of the Caryophyllaceae

  2021cites this paper
• A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis.

  2021cites this paper
• Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy.

  2021cites this paper
• Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats

  2021cites this paper
• Recent Developments in Formulation Design of a Multifunctional Phytochemical Quercetin: A Review

  2021cites this paper
• Drug delivery based pharmacological enhancement and current insights of quercetin with therapeutic potential against oral diseases.

  2020cites this paper
• Quercetin inhibited endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice: Critical roles for NADPH oxidase and heme oxygenase-1.

  2020cites this paper
• Synergistic effect of cranberry extract and losartan against aluminium chloride-induced hepatorenal damage associated cardiomyopathy in rats

  2019cites this paper
• Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function

  2019cites this paper
• Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

  2019cites this paper
• Quercetin, but not rutin, attenuated hydrogen peroxide-induced cell damage via heme oxygenase-1 induction in endothelial cells.

  2019cites this paper
• Cardiomyopathie septique et assistance circulatoire : revue de la littérature et expérience lyonnaise sur 12 ans

  2019cites this paper
• Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages.

  2019cites this paper
• Self-assembly, functionality, and in-vitro properties of quercetin loaded nanoparticles based on shellac-almond gum biological macromolecules.

  2019cites this paper
• Effects of quercetin on microRNAs: A mechanistic review

  2019cites this paper
• Effects of total flavonoids extracted from Polygonum perfoliatum L . on hypolipidemic and antioxidant in hyperlipidemia rats induced by high-fat diet

  2018cites this paper
• Quercetin suppresses breast cancer stem cells (CD44+/CD24−) by inhibiting the PI3K/Akt/mTOR‐signaling pathway

  2018cites this paper
• Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway

  2018cites this paper
• Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury.

  2018cites this paper
• Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health: A Review of Emerging Biologic Pathways

  2018cites this paper
• The value of the Brazilian açai fruit as a therapeutic nutritional strategy for chronic kidney disease patients

  2018cites this paper
• Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial

  2017cites this paper
• Plant Polyphenols in Healthcare and Aging

  2017cites this paper
• Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats

  2017cites this paper
• The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

  2016cites this paper
• Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice.

  2016cites this paper
• Novel Drug Delivery Systems for Herbal Antidepressants

  2016cites this paper
• Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis

  2015cites this paper
• Proinflammatory Pathways: The Modulation by Flavonoids

  2015cites this paper
• Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet

  2015cites this paper
• The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis

  2015cites this paper
• Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

  2015cites this paper
• Dietary contributors to hypertension in adults reviewed

  2015cites this paper
• Effect of flavonoïds from Arbutus unedo leaves on rat isolated thoracic aorta

  2015cites this paper
• Protective effects of quercetin on hepatic cell damage induced by oxidative stress

  2015cites this paper
• Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice.

  2014cites this paper
• Modulation of nitric oxide by flavonoids.

  2014cites this paper
• Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

  2014cites this paper
• Antioxidant Effects of Cranberry Powder in Lipopolysaccharide Treated Hypercholesterolemic Rats

  2014influential citation
• Tetrahydrocurcumin Protects against Cadmium-Induced Hypertension, Raised Arterial Stiffness and Vascular Remodeling in Mice

  2014cites this paper
• Vascular and Antioxidant Effects of an Aqueous Mentha cordifolia Extract in Experimental NG-Nitro-L-arginine Methyl Ester-Induced Hypertension

  2014cites this paper
• Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice

  2013cites this paper
• Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway.

  2013cites this paper
• Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway.

  2013cites this paper
• A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure.

  2013cites this paper
• Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats.

  2013cites this paper
• Role of quercetin in vascular physiology.

  2012cites this paper
• Should we clean up the reputation of "dirty drugs"?

  2012cites this paper