Current trends in analytical determination of vitamin D

S. Khabarov,N. A. Vislotskiy,O. V. Denisova,D. G. Navasardyants

Published 2020 in Medical alphabet

ABSTRACT

Measurement of vitamin D has increased significantly in recent years. Most studies focused on 25(OH)D, which is considered the best indicator of vitamin D status, while there is now more interest in the combined measurement of several clinically significant vitamin D metabolites using the LC–MS/MS technique, which allows simultaneous determination of various vitamin D metabolites over a wide dynamic range. Multi-panel LC–MS/MS analyses are likely to improve future research on the optimal combination of metabolites to assess vitamin D sufficiency, as well as help us better understand its metabolism in normal and pathological changes in the human body. The review examines current trends in analytical determination of vitamin D status and their application in clinical studies.

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