The macrophage phagocytic receptor CD36 promotes fibrogenic pathways on removal of apoptotic cells during chronic kidney injury.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  American Journal of Pathology

• Publication date

  2015-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ajpath.2015.04.016PMID 26092500PMCID PMC4530136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

  2015cited by this paper
• 5-Lypoxygenase Products Are Involved in Renal Tubulointerstitial Injury Induced by Albumin Overload in Proximal Tubules in Mice

  2014cited by this paper
• Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

  2014cited by this paper
• Acute kidney injury and chronic kidney disease as interconnected syndromes.

  2014cited by this paper
• Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor

  2014cited by this paper
• CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury[S]

  2013cited by this paper
• Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury.

  2013cited by this paper
• clearance of apoptotic cells and platelet aggregation A soluble form of the Mer receptor tyrosine kinase inhibits macrophage

  2013cited by this paper
• The scavenger receptor SCARF1 mediates apoptotic cell clearance and prevents autoimmunity

  2013cited by this paper
• Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections.

  2013cited by this paper
• MicroRNA let-7c Regulates Macrophage Polarization

  2013cited by this paper
• Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.

  2013cited by this paper
• M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

  2013cited by this paper
• Induction of TGF-β1 Synthesis by Macrophages in Response to Apoptotic Cells Requires Activation of the Scavenger Receptor CD36

  2013cited by this paper
• The renal mononuclear phagocytic system.

  2012cited by this paper
• Class B Scavenger Receptor Types I and II and CD36 Targeting Improves Sepsis Survival and Acute Outcomes in Mice

  2012cited by this paper
• Mannose receptor 2 attenuates renal fibrosis.

  2012cited by this paper
• CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies.

  2012cited by this paper
• Class B Scavenger Receptor Types I and II and CD36 Mediate Bacterial Recognition and Proinflammatory Signaling Induced by Escherichia coli, Lipopolysaccharide, and Cytosolic Chaperonin 60

  2012cited by this paper
• Distinct macrophage phenotypes contribute to kidney injury and repair.

  2011cited by this paper
• Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

  2011cited by this paper
• Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

  2011cited by this paper
• Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor γ or Retinoid X Receptor α Deficiency

  2011cited by this paper
• Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis.

  2011cited by this paper
• Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.

  2011cited by this paper
• Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis.

  2011cited by this paper
• Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells.

  2010cited by this paper
• The Ngal Reporter Mouse Detects the Response of the Kidney to Injury in Real Time

  2010cited by this paper
• Macrophages and immunologic inflammation of the kidney.

  2010cited by this paper
• T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

  2010cited by this paper
• Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.

  2010cited by this paper
• Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy.

  2009cited by this paper
• CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

  2009cited by this paper
• Mechanisms of Podocyte Injury in Diabetes

  2009cited by this paper
• Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations1

  2009cited by this paper
• CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.

  2009cited by this paper
• Controlling the cell death mediators Bax and Bak: puzzles and conundrums

  2008cited by this paper
• Macrophage diversity in renal injury and repair.

  2008cited by this paper
• Clearance of apoptotic cells by phagocytes

  2008cited by this paper
• Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.

  2008cited by this paper
• CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products.

  2008cited by this paper
• Role of Human CD36 in Bacterial Recognition, Phagocytosis, and Pathogen-Induced JNK-Mediated Signaling1

  2008cited by this paper
• Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene ExpressionMartinez FO, Gordon S, Locati M, et al (Univ of Milan, Italy; Univ of Oxford, England) J Immunol 177:7303–7311, 2006§

  2008influential reference
• Clearance of apoptotic cells by phagocytes.

  2008cited by this paper
• Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury.

  2007cited by this paper
• Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.

  2007influential reference
• Endogenous urokinase lacks antifibrotic activity during progressive renal injury.

  2007cited by this paper
• Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1

  2006cited by this paper
• Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats.

  2006cited by this paper
• A CD36‐dependent signaling cascade is necessary for macrophage foam cell formation

  2006cited by this paper
• Oxidized phosphatidylserine–CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells

  2006influential reference
• Macrophage activation switching: an asset for the resolution of inflammation

  2005cited by this paper
• Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.

  2005cited by this paper
• Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

  2005cited by this paper
• Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

  2005cited by this paper
• Life in the balance: how BH3-only proteins induce apoptosis.

  2005cited by this paper
• Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.

  2005cited by this paper
• Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

  2005cited by this paper
• Author Contributions: K. Susztak,

  2004cited by this paper
• Reduced Macrophage Recruitment, Proliferation, and Activation in Colony-Stimulating Factor-1-Deficient Mice Results in Decreased Tubular Apoptosis During Renal Inflammation 1

  2003cited by this paper
• Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36.

  2003cited by this paper
• A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

  2002cited by this paper
• A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid*

  2002cited by this paper
• CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism.

  2001cited by this paper
• Macrophages Transfected with Adenovirus to Express IL-4 Reduce Inflammation in Experimental Glomerulonephritis1

  2001cited by this paper
• 5-Lipoxygenase Reaction Products Modulate Alveolar Macrophage Phagocytosis of Klebsiella pneumoniae

  1998cited by this paper
• CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).

  1998cited by this paper
• Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

  1992cited by this paper
• Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages.

  1991cited by this paper
• Macrophage Production of TGF‐β and Regulation by TGF‐β

  1990cited by this paper
• Macrophage production of TGF-beta and regulation by TGF-beta.

  1990cited by this paper
• The scavenger receptor SCARF 1 mediates the clearance of apoptotic cells and prevents autoimmunity

  year unknowncited by this paper

• Targeting efferocytosis for tissue regeneration: From microenvironment reprogramming to clinical translation

  2026cites this paper
• The response to kidney injury is epigenetically regulated through the activation of bivalent genes.

  2026cites this paper
• The role of CD36 in immune function: bridging innate and adaptive responses

  2026cites this paper
• PPARα modulation of macrophage polarization and inflammatory signaling in mimic periodontitis

  2025cites this paper
• Lipid Accumulation and Insulin Resistance: Bridging Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Kidney Disease

  2025cites this paper
• Identification and Validation of Aging-Related Genes in IgA Nephropathy in the Asian Population

  2025cites this paper
• Loss of NR2F6 Protects from Salmonella Typhimurium Infection

  2025cites this paper
• Current perspectives and trends of lipid metabolism in chronic kidney diseases: a bibliometric analysis

  2025cites this paper
• In Vitro Modulation of Macrophage Inflammatory and Pro-Repair Properties Essential for Wound Healing by Calcium and Calcium-Alginate Dressings

  2025cites this paper
• Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: implications for atherogenic, tumorigenic, and obesogenic processes.

  2025cites this paper
• Spatial multiomics decipher fibroblast-macrophage dynamics in systemic sclerosis.

  2025cites this paper
• The effects of interleukin-21 in the biology of transplant rejection

  2025cites this paper
• Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers

  2025cites this paper
• Unveiling macrophage dynamics and efferocytosis-related targets in diabetic kidney disease: insights from single-cell and bulk RNA-sequencing

  2025cites this paper
• Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction

  2025cites this paper
• Aging Mediates Inflammatory Transformation of Kidney-Resident Macrophages via Thrombospondin-1 Signaling

  2025cites this paper
• Effect of periostin (OSF-2) on phagocytosis of Plasmodium-infected erythrocytes

  2025cites this paper
• CX3CR1 deficiency promotes resolution of hepatic ischemia-reperfusion injury by regulating homeostatic function of liver infiltrating macrophages.

  2024cites this paper
• Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling

  2024cites this paper
• Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism

  2024cites this paper
• Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

  2024cites this paper
• A sex-dependent role of Kv1.3 channels from macrophages in metabolic syndrome

  2024cites this paper
• Monocyte CD36 Expression Predicts Disease Activity in Patients With Crohn's Disease

  2024cites this paper
• Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis

  2024cites this paper
• CNP Ameliorates Macrophage Inflammatory Response and Atherosclerosis

  2024cites this paper
• Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom

  2023cites this paper
• Naoxueshu oral liquid promotes hematoma absorption by targeting CD36 in M2 microglia via TLR4/MyD88/NF-κB signaling pathway in rats with intracerebral hemorrhage.

  2023cites this paper
• Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis.

  2023cites this paper
• Biochemical and molecular inducers and modulators of M2 macrophage polarization in clinical perspective.

  2023cites this paper
• Damage-mediated macrophage polarization in sterile inflammation

  2023cites this paper
• The Role of CD36 in Cancer Progression and Its Value as a Therapeutic Target

  2023cites this paper
• Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate

  2023cites this paper
• Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

  2023influential citation
• Fatty Acid β-Oxidation in Kidney Diseases: Perspectives on Pathophysiological Mechanisms and Therapeutic Opportunities

  2022influential citation
• Macrophages in transplant rejection.

  2022cites this paper
• CD36 is Associated With the Development of Coronary Artery Lesions in Patients With Kawasaki Disease

  2022cites this paper
• Wound healing and regeneration in spiny mice (Acomys cahirinus).

  2022cites this paper
• Signaling pathways of chronic kidney diseases, implications for therapeutics

  2022cites this paper
• Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy

  2022cites this paper
• Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

  2022cites this paper
• Mammalian organ regeneration in spiny mice

  2022cites this paper
• Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment

  2022cites this paper
• Examination of the emerging role of transporters in the assessment of nephrotoxicity

  2022cites this paper
• Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages

  2022cites this paper
• Microarray Expression Profile of Myricetin-Treated THP-1 Macrophages Exhibits Alterations in Atherosclerosis-Related Regulator Molecules and LXR/RXR Pathway

  2022cites this paper
• Druggability of lipid metabolism modulation against renal fibrosis

  2021cites this paper
• Intestinal Intervention Strategy Targeting Myeloid Cells to Improve Hepatic Immunity during Hepatocarcinoma Development

  2021cites this paper
• Precise Delivery of Nanomedicines to M2 Macrophages by Combining "Eat Me/Don't Eat Me" Signals and Its Anticancer Application.

  2021cites this paper
• Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

  2021cites this paper
• Increased CD47 and MHC Class I Inhibitory Signals Expression in Senescent CD1 Primary Mouse Lung Fibroblasts

  2021cites this paper
• Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

  2021cites this paper
• Gene expression during THP-1 differentiation is influenced by vitamin D3 and not vibrational mechanostimulation

  2021cites this paper
• Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?

  2021cites this paper
• CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

  2021cites this paper
• Recent Progress on Lipid Intake and Chronic Kidney Disease

  2020cites this paper
• Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction

  2020cites this paper
• Dyslipidemia in Kidney Disorders: Perspectives on Mitochondria Homeostasis and Therapeutic Opportunities

  2020cites this paper
• Lipid Players of Cellular Senescence

  2020cites this paper
• CD36 and CD97 in Pancreatic Cancer versus Other Malignancies

  2020cites this paper
• A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells.

  2020cites this paper
• The many faces of macrophages : polarization, endotoxin priming, and Salmonella resistance

  2020cites this paper
• A network-regulative pattern in the pathogenesis of kidney injury following severe acute pancreatitis.

  2020cites this paper
• Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP‐α in peritoneal macrophages

  2019cites this paper
• miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism

  2019cites this paper
• CD36 tango in cancer: signaling pathways and functions

  2019cites this paper
• Lipid Metabolism Disorder and Renal Fibrosis.

  2019cites this paper
• Therapeutic potentials of Scavenger receptor CD36 mediated innate immune responses against infectious and non-infectious diseases.

  2019cites this paper
• The role of CNS macrophages in streptococcal meningoencephalitis

  2019cites this paper
• Macrophages: versatile players in renal inflammation and fibrosis

  2019cites this paper
• Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

  2018cites this paper
• Scarless repair of acute and chronic kidney injury in African Spiny mice (Acomys cahirinus)

  2018cites this paper
• Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis

  2018cites this paper
• The lack of PI3K&ggr; favors M1 macrophage polarization and does not prevent kidney diseases progression

  2018cites this paper
• Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury

  2018cites this paper
• Efferocytosis capacities of blood monocyte‐derived macrophages in systemic sclerosis

  2018cites this paper
• Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields

  2018cites this paper
• Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

  2018cites this paper
• Impact of Pulmonary Surfactant on Human Macrophage Susceptibility to Mycobacterium tuberculosis

  2017cites this paper
• Unilateral nephrectomy diminishes ischemic acute kidney injury through enhanced perfusion and reduced pro-inflammatory and pro-fibrotic responses

  2017cites this paper
• Nanomedicines for dysfunctional macrophage-associated diseases.

  2017cites this paper
• CD36 in chronic kidney disease: novel insights and therapeutic opportunities

  2017cites this paper
• Anxiety leads to up-regulation of CD36 on the monocytes of chronic hepatitis B-infected patients

  2016cites this paper
• Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

  2016cites this paper
• Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.

  2016cites this paper
• Results Competition of 5 A peptide and known CD 36 ligands with Alexa-Fluor 488 oxLDL in CD 36-overexpressing HeLa cells

  2016cites this paper
• The balance of powers: Redox regulation of fibrogenic pathways in kidney injury

  2015cites this paper