Raloxifene, a Mixed Estrogen Agonist/Antagonist, Induces Apoptosis through Cleavage of BAD in TSU-PR1 Human Cancer Cells*

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-09-06

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.M202852200PMID 12084714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transforming Growth Factor β1 Induces Apoptosis through Cleavage of BAD in a Smad3-Dependent Mechanism in FaO Hepatoma Cells

  2002cited by this paper
• Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells.

  2002cited by this paper
• TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.

  2001cited by this paper
• Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

  2001cited by this paper
• Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.

  2001cited by this paper
• BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

  2001cited by this paper
• Bcl-xL Blocks Transforming Growth Factor-β1-induced Apoptosis by Inhibiting Cytochrome c Release and Not by Directly Antagonizing Apaf-1-dependent Caspase Activation in Prostate Epithelial Cells*

  2001cited by this paper
• Caspase Cleavage Enhances the Apoptosis-Inducing Effects of BAD

  2001cited by this paper
• 14-3-3 inhibits Bad-induced cell death through interaction with serine-136.

  2001cited by this paper
• Reciprocal Expression of ERα and ERβ Is Associated with Estrogen-mediated Modulation of Intestinal Tumorigenesis

  2001cited by this paper
• BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival*

  2000cited by this paper
• Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects.

  2000cited by this paper
• Immunolocalisation of oestrogen receptor beta in human tissues.

  2000cited by this paper
• Differential expression of estrogen receptors alpha and beta in adult rat accessory sex glands and lower urinary tract.

  2000cited by this paper
• Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.

  2000cited by this paper
• Growth Factors Inactivate the Cell Death Promoter BAD by Phosphorylation of Its BH3 Domain on Ser155 *

  2000cited by this paper
• Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements*

  2000cited by this paper
• Differential expression of estrogen receptors α and β in adult rat accessory sex glands and lower urinary tract

  2000cited by this paper
• Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation.

  2000cited by this paper
• Localization of androgen and estrogen receptors in rat and primate tissues.

  2000cited by this paper
• Protein phosphatase 1α is a Ras‐activated Bad phosphatase that regulates interleukin‐2 deprivation‐induced apoptosis

  2000cited by this paper
• Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

  1999cited by this paper
• Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators.

  1999cited by this paper
• The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation.

  1999cited by this paper
• Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

  1999cited by this paper
• BCL-2 family members and the mitochondria in apoptosis.

  1999cited by this paper
• An estrogen receptor basis for raloxifene action in bone.

  1999cited by this paper
• Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules.

  1999cited by this paper
• Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.

  1998cited by this paper
• Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

  1998cited by this paper
• Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

  1998cited by this paper
• Generation and reproductive phenotypes of mice lacking estrogen receptor beta.

  1998cited by this paper
• Apoptosis: A Bad kinase makes good

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.

  1997cited by this paper
• BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity*

  1997cited by this paper
• Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse.

  1997cited by this paper
• Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

  1996cited by this paper
• ER beta: identification and characterization of a novel human estrogen receptor.

  1996cited by this paper
• Intrauterine 5-Aminolevulinic Acid Induces Selective Endometrial Fluorescence in the Rhesus and Cynomolgus Monkey

  1996cited by this paper
• ERβ: Identification and characterization of a novel human estrogen receptor

  1996cited by this paper
• Cloning of a novel receptor expressed in rat prostate and ovary.

  1996cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

  1986cited by this paper

• The Role of Estrogen Signaling Pathway and Targeted Therapy Exploration in Urological Tumors

  2026cites this paper
• Novel Anticancer Triple Formula Based on Aptamer-Conjugated PEGylated Nanoliposomes

  2025cites this paper
• Sex bias in tumor immunity: insights from immune cells

  2025cites this paper
• Bipyraloxifene – a modified raloxifene vector against triple-negative breast cancer

  2024cites this paper
• Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer

  2024cites this paper
• Raloxifene prevents intracellular invasion of pathogenic bacteria through modulation of cell metabolic pathways.

  2022cites this paper
• Raloxifene potentiates the effect of gefitinib in triple-negative breast cancer cell lines

  2022influential citation
• Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy

  2021cites this paper
• The Role of Estrogen Receptors in Urothelial Cancer

  2021cites this paper
• Clinicopathological Significance of Estrogen Receptor β and Estrogen Synthesizing/Metabolizing Enzymes in Urothelial Carcinoma of Urinary Bladder

  2021cites this paper
• The Inequality of Females in Bladder Cancer

  2021cites this paper
• The prognostic role of steroid hormone receptor signaling pathways in urothelial carcinoma

  2020cites this paper
• Selective estrogen receptor modulator with estrogen does not affect the proliferation and apoptosis of uterine leiomyoma cells

  2020cites this paper
• Raloxifene nano-micelles effect on triple-negative breast cancer is mediated through estrogen receptor-β and epidermal growth factor receptor

  2019cites this paper
• Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications

  2018cites this paper
• Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications

  2018cites this paper
• Association of Aromatase With Bladder Cancer Stage and Long‐Term Survival: New Insights Into the Hormonal Paradigm in Bladder Cancer

  2017cites this paper
• Histopathological and prognostic significance of the expression of sex hormone receptors in bladder cancer: A meta-analysis of immunohistochemical studies

  2017cites this paper
• Raloxifene: Promises and Challenges as a Drug Treatment for Castrate Resistant Prostate Cancer

  2017cites this paper
• History of monoclonal antibodies and lessons for the development of stem cell therapeutics

  2016cites this paper
• Ameliorative potential of fluoxetine/raloxifene combination on experimentally induced breast cancer.

  2016cites this paper
• Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor

  2015cites this paper
• Prostate cancer stem cells: the role of androgen and estrogen receptors

  2015cites this paper
• Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

  2015cites this paper
• Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells.

  2014influential citation
• Role of oestrogen receptors in bladder cancer development

  2013cites this paper
• Raloxifene reduces triple-negative breast cancer tumor growth and decreases EGFR expression.

  2013cites this paper
• Estrogen receptor-β expression and pharmacological targeting in bladder cancer

  2013cites this paper
• Biomarkers in urothelial carcinoma of the bladder: the potential cross-talk between transforming growth factor-β1 and estrogen receptor β/androgen receptor pathways.

  2013cites this paper
• Chemoprevention of BBN-Induced Bladder Carcinogenesis by the Selective Estrogen Receptor Modulator Tamoxifen.

  2013cites this paper
• High circulating estrogens and selective expression of ERβ in prostate tumors of Americans: implications for racial disparity of prostate cancer.

  2013cites this paper
• ZEN and the art of breast health maintenance

  2012cites this paper
• Nuclear hormone receptor signals as new therapeutic targets for urothelial carcinoma.

  2012cites this paper
• Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder

  2012cites this paper
• Recent advances in the synthesis of raloxifene: a selective estrogen receptor modulator.

  2012cites this paper
• The effect of raloxifene on Bax protein expression in breast carcinomas of postmenopausal women

  2012cites this paper
• Raloxifene for the Treatment of Triple Negative Breast Cancer

  2012cites this paper
• Raloxifene Inhibits Growth of RT4 Urothelial Carcinoma Cells via Estrogen Receptor-Dependent Induction of Apoptosis and Inhibition of Proliferation

  2012cites this paper
• Nuclear Matrix Proteins in Disparity of Prostate Cancer

  2011cites this paper
• Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptorα and β

  2011cites this paper
• Estrogens and prostate cancer: etiology, mediators, prevention, and management.

  2011cites this paper
• Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia.

  2010cites this paper
• Effects of zearalenone and α-Zearalenol in comparison with Raloxifene on T47D cells

  2009cites this paper
• The combination of raloxifene and epigallocatechin gallate suppresses growth and induces apoptosis in MDA-MB-231 cells.

  2008cites this paper
• [Expression of Bax protein in normal tissue of premenopausal women treated with raloxifene].

  2008cites this paper
• Regulation of Bcl-2 family proteins by posttranslational modifications.

  2008cites this paper
• Apoptosis induced by ardipusilloside III through BAD dephosphorylation and cleavage in human glioblastoma U251MG cells

  2008cites this paper
• Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma.

  2007cites this paper
• Apoptosis in raloxifene‐treated postmenopausal women

  2007influential citation
• Unique Bisphenol A Transcriptome in Prostate Cancer: Novel Effects on ERβ Expression That Correspond to Androgen Receptor Mutation Status

  2007cites this paper
• Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue

  2006cites this paper
• Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue.

  2006cites this paper
• Reproductive risk factors for incident bladder cancer: Iowa Women's Health Study

  2006cites this paper
• Raloxifene, an oestrogen‐receptor‐β‐targeted therapy, inhibits androgen‐independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial

  2006cites this paper
• Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

  2005cites this paper
• Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor.

  2005cites this paper
• Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships.

  2005cites this paper
• Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis.

  2004cites this paper
• Role of raloxifene in breast cancer prevention in postmenopausal women: clinical evidence and potential mechanisms of action.

  2004cites this paper
• BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function*

  2004cites this paper
• BAD is a Central Player in Cell Death and Cell Cycle Regulation in Breast Cancer Cells

  2004cites this paper
• Involvement of Akt in mitochondria‐dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog

  2003cites this paper
• Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP.

  2003cites this paper
• Estrogens and parkinson disease

  2003cites this paper
• Cleavage of Bax to p 18 Bax accelerates stress-induced apoptosis , and a cathepsin-like protease may rapidly degrade p 18 Bax

  2003cites this paper
• Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax.

  2003cites this paper