Effect of CO2 on the Expression of cyclooxigenase in Vascular Smooth Muscle Cells

Taichi Nakamura,N. Sugimoto,Naoki Nishimura,T. Wada

Published 2021 in The FASEB Journal

ABSTRACT

Carbon dioxide(CO2) is one of the factors that affect the constriction and dilatation of smooth muscle cells. Cyclooxigenase(COX) catalyzes have important roles in inducing inflammatory responses and prostanoids, generated from arachidonic acid by COX‐1 and COX‐2, are involved in modulating of vascular tone. This study aimed to clarify the role of CO2 in regulating COX expression in vascular smooth muscle cells and elucidate its effects for vascular endothelial function.

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