Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Endocrinology

• Publication date

  2011-05-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1210/me.2011-0033PMID 21566081PMCID PMC3125094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arginine Methylation by PRMT5 at a Naturally Occurring Mutation Site Is Critical for Liver Metabolic Regulation by Small Heterodimer Partner

  2011cited by this paper
• Nuclear Receptor SHP, a Death Receptor That Targets Mitochondria, Induces Apoptosis and Inhibits Tumor Growth

  2010cited by this paper
• Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP)

  2010cited by this paper
• A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition*

  2010cited by this paper
• SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule–mediated nuclear factor-κB activation, c-Fos/c-Jun expression, and cellular apoptosis

  2009cited by this paper
• Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.

  2009cited by this paper
• The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.

  2009cited by this paper
• Functional Specificities of Brm and Brg-1 Swi/Snf ATPases in the Feedback Regulation of Hepatic Bile Acid Biosynthesis

  2009cited by this paper
• Molecular basis of endocrine regulation by orphan nuclear receptor Small Heterodimer Partner.

  2008cited by this paper
• Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

  2008cited by this paper
• The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP*

  2008cited by this paper
• Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containin

  2008cited by this paper
• Activation of Bile Acid Biosynthesis by the p38 Mitogen-activated Protein Kinase (MAPK)

  2007cited by this paper
• An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.

  2007cited by this paper
• Hepatocyte growth factor signaling pathway inhibits cholesterol 7α‐hydroxylase and bile acid synthesis in human hepatocytes

  2007cited by this paper
• Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

  2007cited by this paper
• Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

  2007cited by this paper
• Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

  2006cited by this paper
• Bile acids and cytokines inhibit the human cholesterol 7α‐hydroxylase gene via the JNK/c‐jun pathway in human liver cells

  2006cited by this paper
• Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism

  2006cited by this paper
• Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.

  2005cited by this paper
• Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP

  2005cited by this paper
• Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression.

  2004cited by this paper
• LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.

  2004cited by this paper
• Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

  2004cited by this paper
• Role of an mSin3A-Swi/Snf Chromatin Remodeling Complex in the Feedback Repression of Bile Acid Biosynthesis by SHP

  2004cited by this paper
• Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

  2004cited by this paper
• Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding.

  2004cited by this paper
• p38 MAP kinase: a convergence point in cancer therapy.

  2004cited by this paper
• Ligand-activated Pregnane X Receptor Interferes with HNF-4 Signaling by Targeting a Common Coactivator PGC-1α

  2004cited by this paper
• Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription.

  2004cited by this paper
• Retinoid targets for apoptosis induction

  2003cited by this paper
• Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

  2003cited by this paper
• Does loss of bile acid homeostasis make mice melancholy?

  2002cited by this paper
• Redundant pathways for negative feedback regulation of bile acid production.

  2002cited by this paper
• A sharper image of SHP

  2002cited by this paper
• Bile acid regulation of gene expression: roles of nuclear hormone receptors.

  2002cited by this paper
• Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner*

  2002cited by this paper
• Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.

  2001cited by this paper
• Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway*

  2001cited by this paper
• The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors

  2000cited by this paper
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

  2000cited by this paper
• The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

  2000cited by this paper
• Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

  2000cited by this paper
• An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

  1996cited by this paper
• Nuclear receptors (...

  year unknowncited by this paper

• The mechanisms of farnesoid X receptor-mediated protection against high-fat diet-induced hepatic lipid deposition in yellow catfish (Pelteobagrus fulvidraco)

  2025cites this paper
• MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway

  2025cites this paper
• Role of protein regulators of cholesterol homeostasis in immune modulation and cancer pathophysiology.

  2025cites this paper
• Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

  2024cites this paper
• Gypensapogenin A-Liposomes Efficiently Ameliorates Hepatocellular Lipid Accumulation via Activation of FXR Receptor

  2024cites this paper
• Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats

  2023cites this paper
• Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

  2023cites this paper
• FXR Friend-ChIPs in the Enterohepatic System

  2023cites this paper
• Discovery of farnesoid X receptor and its role in bile acid metabolism.

  2022cites this paper
• Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures

  2022cites this paper
• Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling

  2022cites this paper
• NF‐κB Regulation of LRH‐1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition–Associated Cholestasis

  2021cites this paper
• Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism.

  2021cites this paper
• Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes

  2021cites this paper
• Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

  2020cites this paper
• MiRNA-200b-3p represses LRH-1 expression and is associated with reduced serum bile acid in human obstructive cholestasis

  2020cites this paper
• The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice.

  2020cites this paper
• The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction.

  2019cites this paper
• Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages.

  2019cites this paper
• Role of the orphan nuclear receptor NR5A2 in ovarian function

  2019cites this paper
• The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.

  2019cites this paper
• 3‐Cl‐AHPC inhibits pro‐HGF maturation by inducing matriptase/HAI‐1 complex formation

  2018cites this paper
• The interrelationship between bile acid and vitamin A homeostasis.

  2017cites this paper
• Bile Acid Physiology.

  2017cites this paper
• Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals

  2017cites this paper
• Bile Acids and Cancer: Direct and Environmental-Dependent Effects.

  2017cites this paper
• The Biliary System: Second Edition

  2016cites this paper
• Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

  2016cites this paper
• Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis.

  2016cites this paper
• The orphan nuclear receptor NR5A2 regulates peri-ovulatory events and their consequent luteinization in mice

  2014cites this paper
• Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention.

  2014cites this paper
• Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective

  2013cites this paper
• The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

  2013cites this paper
• The role of vitamin A in bile acid synthesis and transport and the relevance for cholestatic liver disease

  2013cites this paper
• Retinoic acid related orphan nuclear receptor alpha (RORalpha) regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase (CYP8B1) in bile acid synthesis

  2013cites this paper
• FXR signaling in the enterohepatic system.

  2013cites this paper
• Steatosis in the liver.

  2013cites this paper
• Structural insights into gene repression by the orphan nuclear receptor SHP

  2013cites this paper
• The orphan nuclear receptors at their 25-year reunion.

  2013cites this paper
• Epigenomic regulation of bile acid metabolism: emerging role of transcriptional cofactors.

  2013cites this paper
• The Biliary System

  2012cites this paper
• Nuclear receptor control of enterohepatic circulation.

  2012influential citation
• A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways

  2012cites this paper
• Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways

  2012cites this paper