WAVE2, N‐WASP, and mena facilitate cell invasion via phosphatidylinositol 3‐kinase‐dependent local accumulation of actin filaments

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcb.23276PMID 21769917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2.

  2010cited by this paper
• Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex.

  2009cited by this paper
• Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia.

  2009influential reference
• Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells.

  2008cited by this paper
• Role of platelet-derived growth factors in physiology and medicine.

  2008cited by this paper
• Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor.

  2008cited by this paper
• Ena/VASP Proteins Capture Actin Filament Barbed Ends*

  2008influential reference
• Ena/VASP proteins have an anti-capping independent function in filopodia formation.

  2007influential reference
• WAVE3-mediated Cell Migration and Lamellipodia Formation Are Regulated Downstream of Phosphatidylinositol 3-Kinase*

  2005cited by this paper
• Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization

  2004cited by this paper
• Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells.

  2004cited by this paper
• N-WASP and WAVE2 Acting Downstream of Phosphatidylinositol 3-Kinase Are Required for Myogenic Cell Migration Induced by Hepatocyte Growth Factor*

  2004cited by this paper
• Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.

  2003cited by this paper
• IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena

  2003influential reference
• Metastasis: Dissemination and growth of cancer cells in metastatic sites

  2002cited by this paper
• Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility.

  2002influential reference
• WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.

  2001cited by this paper
• Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.

  2001influential reference
• N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia.

  2001influential reference
• Negative regulation of fibroblast motility by Ena/VASP proteins.

  2000cited by this paper
• Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

  2000cited by this paper
• Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

  1999cited by this paper
• VASP dynamics during lamellipodia protrusion

  1999influential reference
• Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.

  1999influential reference
• Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

  1999influential reference
• WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac

  1998cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998cited by this paper
• Actin-based cell motility and cell locomotion.

  1996cited by this paper
• Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

  1996influential reference
• N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases.

  1996cited by this paper
• PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.

  1995influential reference
• A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

  1994influential reference
• Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.

  1994influential reference
• Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

  1994influential reference
• Interaction of rat ascites hepatoma cells with cultured mesothelial cell layers: a model for tumor invasion.

  1986cited by this paper
• Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.

  1979cited by this paper
• Methyl labeling of HeLa cell hnRNA: a comparison with mRNA.

  1976cited by this paper
• A platelet factor stimulating human normal glial cells.

  1976cited by this paper
• Platelets as a source of fibroblast growth-promoting activity.

  1974cited by this paper

• FOXP2 suppresses gastric cancer progression by transcriptionally repressing FBXW2 via WASL degradation

  2025cites this paper
• CD9 downregulation activates EGFR/ERK/WAVE2 pathway to remodel F-actin and promote proliferation and migration of cholesteatoma epithelial cells.

  2025cites this paper
• ENAH transcriptionally activated by YY1 promotes growth and invasion of laryngocarcinoma cells through PI3K/AKT signaling.

  2024cites this paper
• The C. elegans anchor cell: A model to elucidate mechanisms underlying invasion through basement membrane.

  2023cites this paper
• The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer

  2023cites this paper
• WASF2 Serves as a Potential Biomarker and Therapeutic Target in Ovarian Cancer: A Pan-Cancer Analysis

  2022cites this paper
• The Role of the Adapter Protein Anks1a in the Regulation of Breast Cancer Cell Motility

  2022cites this paper
• Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

  2021cites this paper
• Role of RhoC in cancer cell migration

  2021cites this paper
• The Role of WAVE2 Signaling in Cancer

  2021cites this paper
• Targeting WASF3 Signaling in Metastatic Cancer

  2021cites this paper
• Actin regulators in cancer progression and metastases: From structure and function to cytoskeletal dynamics.

  2020cites this paper
• Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer

  2020cites this paper
• New insights into the regulation of the actin cytoskeleton dynamics by GPCR/β-arrestin in cancer invasion and metastasis.

  2019cites this paper
• Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer

  2018cites this paper
• Expression status of cytoskeleton regulatory protein Mena as a prognostic marker for human thyroid carcinoma.

  2018cites this paper
• Identification and characterization of MicroRNAs modulating cardiac hypertrophy

  2017cites this paper
• N-WASP promotes invasion and migration of cervical cancer cells through regulating p38 MAPKs signaling pathway.

  2017cites this paper
• Validation of nWASP as a therapeutic target in chronic and non-healing human wounds

  2017cites this paper
• Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance

  2017cites this paper
• Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

  2016cites this paper
• microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements

  2015cites this paper
• Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

  2015cites this paper
• Role of the wASP and wAve family proteins in breast cancer invasion and metastasis

  2015cites this paper
• N-WASP in Pancreatic Ductal Adenocarcinoma: Associations with Perineural Invasion and Poor Prognosis

  2014cites this paper
• Decreased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 may be involved in the development of pre-eclampsia.

  2014cites this paper
• Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.

  2014cites this paper
• WAVE 2 Protein Complex Coupled toMembrane andMicrotubules

  2014cites this paper
• c-Src and Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promote Low Oxygen-Induced Accelerated Brain Invasion by Gliomas

  2013cites this paper
• Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth restriction.

  2013cites this paper
• N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis.

  2013cites this paper
• The Possible Role of Mena Protein and Its Splicing-Derived Variants in Embryogenesis, Carcinogenesis, and Tumor Invasion: A Systematic Review of the Literature

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• miR-23a promotes the transition from indolent to invasive colorectal cancer.

  2012cites this paper
• WAVE2 Protein Complex Coupled to Membrane and Microtubules

  2012cites this paper