Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biological chemistry

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine, Chemistry, Computer Science

• Identifiers
  DOI 10.1515/BC.2011.158PMID 21846260
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

  2011cited by this paper
• Old and new anticoagulants

  2011cited by this paper
• Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

  2010cited by this paper
• The Proteomics Identifications database: 2010 update

  2009cited by this paper
• Improved visualization of protein consensus sequences by iceLogo

  2009influential reference
• Factor Xa Active Site Substrate Specificity with Substrate Phage Display and Computational Molecular Modeling*

  2008influential reference
• Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

  2008influential reference
• Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini.

  2008cited by this paper
• Profiling constitutive proteolytic events in vivo.

  2007cited by this paper
• Mapping Protease Substrates by Using a Biotinylated Phage Substrate Library

  2006influential reference
• Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays

  2005influential reference
• Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis

  2005cited by this paper
• The International Protein Index: An integrated database for proteomics experiments

  2004influential reference
• TANDEM: matching proteins with tandem mass spectra.

  2004influential reference
• Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

  2003influential reference
• Mapping of the Catalytic Groove Preferences of Factor Xa Reveals an Inadequate Selectivity for Its Macromolecule Substrates*

  2002influential reference
• Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases.

  2002influential reference
• Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search.

  2002influential reference
• Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.

  2000influential reference
• Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.

  2000cited by this paper
• Subunit structure and function of porcine factor Xa-activated factor VIII.

  1997cited by this paper
• X-ray Structure of Active Site-inhibited Clotting Factor Xa

  1996cited by this paper
• Human Immunodeficiency Virus, Type 1 Protease Substrate Specificity Is Limited by Interactions between Substrate Amino Acids Bound in Adjacent Enzyme Subsites (*)

  1996cited by this paper
• Substrate phage: selection of protease substrates by monovalent phage display.

  1993influential reference
• Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin.

  1988cited by this paper
• Prothrombinase complex assembly. Kinetic mechanism of enzyme assembly on phospholipid vesicles.

  1988cited by this paper
• Oxygen binding properties of human mutant hemoglobins synthesized in Escherichia coli.

  1985cited by this paper
• Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.

  1984cited by this paper
• The factor Xa-catalyzed activation of factor V.

  1983cited by this paper
• Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.

  1981cited by this paper

• N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins

  2025influential citation
• An Introductory Guide to Protease Sensitive Linker Design Using Matrix Metalloproteinase 13 as an Example.

  2024cites this paper
• Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CLpro main protease (Mpro) from proteomic identification of P6—P6' active site specificity

  2024cites this paper
• Comprehensive protease specificity profiling

  2024cites this paper
• Substrate derived sequences act as subsite‐blocking motifs in protease inhibitory antibodies

  2023cites this paper
• Innovative workflow for the identification of cathepsin K cleavage sites in type I collagen.

  2023cites this paper
• Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches

  2021cites this paper
• Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

  2021cites this paper
• Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

  2021cites this paper
• Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin

  2021cites this paper
• Peptide signaling for drought-induced tomato flower drop

  2020cites this paper
• N-terminomics - its past and recent advancements.

  2020cites this paper
• Identification and characterization of the proteolytic flagellin from the common freshwater bacterium Hylemonella gracilis

  2020cites this paper
• Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components.

  2020cites this paper
• Proteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates.

  2019cites this paper
• An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.

  2019cites this paper
• Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics.

  2019cites this paper
• Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

  2018cites this paper
• The tomato subtilase family includes several cell death-related proteinases with caspase specificity

  2018cites this paper
• Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics*

  2018cites this paper
• Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

  2017cites this paper
• Functional and structural characterization of synthetic cardosin B-derived rennet

  2017cites this paper
• Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data

  2017cites this paper
• Identification of Protease Specificity Using Biotin-Labeled Substrates

  2017cites this paper
• Profiling of Protease Cleavage Sites by Proteome-Derived Peptide Libraries and Quantitative Proteomics.

  2017cites this paper
• Proteolytic Cleavage-Mechanisms, Function, and "Omic" Approaches for a Near-Ubiquitous Posttranslational Modification.

  2017cites this paper
• Monitoring proteolytic processing events by quantitative mass spectrometry

  2017influential citation
• Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini.

  2017cites this paper
• 3D proteochemometrics: using three-dimensional information of proteins and ligands to address aspects of the selectivity of serine proteases.

  2017cites this paper
• Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.

  2017cites this paper
• System-Wide Profiling of Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissue Specimens for the Identification of Novel Substrates.

  2017cites this paper
• Mass spectrometry-based determination of Kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency

  2017cites this paper
• Functional Characterization of Propeptides in Plant Subtilases as Intramolecular Chaperones and Inhibitors of the Mature Protease *

  2016cites this paper
• Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

  2016cites this paper
• Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics*

  2016cites this paper
• Fibroblast activation protein‐α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

  2016cites this paper
• Characterization of BACE2 substrate specificity by determining its preferred peptide substrate sequences

  2016cites this paper
• The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain

  2016cites this paper
• Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

  2016cites this paper
• Identification of Protease Substrates in Complex Proteomes by iTRAQ-TAILS on a Thermo Q Exactive Instrument

  2015cites this paper
• A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

  2015cites this paper
• Monitoring matrix metalloproteinase activity at the epidermal–dermal interface by SILAC‐iTRAQ‐TAILS

  2015cites this paper
• Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions*

  2015cites this paper
• TAILS N-terminomic and proteomic datasets of healthy human dental pulp

  2015cites this paper
• Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

  2014cites this paper
• Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity.

  2014cites this paper
• Cleavage Specificity Analysis of Six Type II Transmembrane Serine Proteases (TTSPs) Using PICS with Proteome-Derived Peptide Libraries

  2014cites this paper
• Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

  2014cites this paper
• Time-resolved Analysis of the Matrix Metalloproteinase 10 Substrate Degradome*

  2013cites this paper
• Cleavage Entropy as Quantitative Measure of Protease Specificity

  2013cites this paper
• Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells

  2013cites this paper
• Proteomic identification of protease cleavage sites: cell-biological and biomedical applications

  2013cites this paper
• Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances

  2013cites this paper
• Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome*

  2012cites this paper
• CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data

  2012cites this paper
• NSP4, an elastase-related protease in human neutrophils with arginine specificity

  2012cites this paper
• Coagulation Factor Xa

  2012cites this paper
• Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25)

  2012cites this paper
• N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification.

  2012cites this paper
• Quantitative protease cleavage site profiling using tandem-mass-tag labeling and LC-MALDI-TOF/TOF MS/MS analysis.

  2012cites this paper
• Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25)NTINCLEAVAGESENHANCECELLMIGRATIONANDMACROPHAGE

  2012cites this paper