Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bioorganic & Medicinal Chemistry

• Publication date

  2009-02-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmc.2008.12.058PMID 19157884
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Computational Studies to Discover a New NR2B/NMDA Receptor Antagonist and Evaluation of Pharmacological Profile

  2008cited by this paper
• NMDA receptor subunits: function and pharmacology.

  2007cited by this paper
• Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding

  2007cited by this paper
• Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

  2006cited by this paper
• New benzoyl urea derivatives as novel NR2B selective NMDA receptor antagonists.

  2006cited by this paper
• Glutamate-based therapeutic approaches: NR2B receptor antagonists.

  2006cited by this paper
• NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore.

  2006cited by this paper
• Glutamate receptor ion channels.

  2005cited by this paper
• NR2B subtype-selective NMDA receptor antagonists: 2001 – 2004

  2005cited by this paper
• The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.

  2004cited by this paper
• Oxamides as novel NR2B selective NMDA receptor antagonists.

  2004cited by this paper
• NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.

  2004cited by this paper
• The NR2B-Selective N-Methyl-D-aspartate Receptor Antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine Propanol] Potentiates the Effect of Nicotine on Locomotor Activity and Dopamine Release in the Nucleus Accumbens

  2004cited by this paper
• Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket

  2003cited by this paper
• Orally efficacious NR2B-selective NMDA receptor antagonists.

  2003cited by this paper
• Opposing effects by pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide on hippocampal synaptic transmission.

  2003cited by this paper
• The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.

  2003cited by this paper
• NR2B selective NMDA receptor antagonists.

  2002cited by this paper
• CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents.

  2000cited by this paper
• Antagonists selective for NMDA receptors containing the NR2B subunit.

  1999cited by this paper
• Development and validation of a genetic algorithm for flexible docking.

  1997cited by this paper
• Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures.

  1984cited by this paper
• Reactivity of 1H-pyrrolo[2,3-b]pyridine. I. Synthesis of 3-acetyl-7- azaindole and related compounds

  1982cited by this paper
• A method for rapid graphic solution of time-per cent effect curves.

  1949cited by this paper
• A method for rapid graphic solution of time-per cent effect curves.

  1949cited by this paper

• Cenobamate enhances the anticonvulsant effect of other antiseizure medications in the DBA/2 mouse model of reflex epilepsy.

  2023cites this paper
• Bisindolemethane derivatives as highly potent anticancer agents: Synthesis, medicinal activity evaluation, cell-based compound discovery, and computational target predictions

  2020cites this paper
• Simplification of Natural β-Carboline Alkaloids to Obtain Indole Derivatives as Potent Fungicides against Rice Sheath Blight

  2020cites this paper
• A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists.

  2020cites this paper
• Repurposing of cefpodoxime proxetil as potent neuroprotective agent through computational prediction and in vitro validation

  2020cites this paper
• Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety.

  2020cites this paper
• An insight into the medicinal perspective of synthetic analogs of indole: A review.

  2019cites this paper
• Recent Advances Made on Anticancer Drugs – The Therapeutic Potential of the Aromatic Heterocyclic Compounds

  2019cites this paper
• Design, synthesis and biological evaluation of 1-benzyl-5-oxopyrrolidine-2-carboximidamide derivatives as novel neuroprotective agents.

  2019cites this paper
• Exploration of structural and physicochemical properties of small molecules to inhibit NMDA functionality

  2018cites this paper
• Synthesis and biological evaluation of an indole core-based derivative with potent antimicrobial activity

  2018cites this paper
• Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands

  2018cites this paper
• Nanohybrid of ZnO‐RGO as Heterogeneous Green Catalyst for the Synthesis of Medicinally Significant Indole Alkaloids and Their Derivatives

  2018cites this paper
• Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit.

  2016cites this paper
• Structural investigations by in silico modeling for designing NR2B subunit selective NMDA receptor antagonists

  2015cites this paper
• Chemistry of 3-(2-Haloacyl)indoles

  2015cites this paper
• Indoles as anticancer agents

  2015cites this paper
• Indoles as anti-cancer agents

  2015cites this paper
• SYNTHESIS, MOLECULAR DOCKING OF NOVEL INDOL-2-CARBOXAMIDE DERIVATIVES WITH ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITIES

  2014cites this paper
• From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands.

  2014cites this paper
• Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors.

  2014cites this paper
• Targeting GluN2B‐Containing N‐Methyl‐D‐aspartate Receptors: Design, Synthesis, and Binding Affinity Evaluation of Novel 3‐Substituted Indoles

  2014cites this paper
• Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy.

  2013cites this paper
• Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

  2013cites this paper
• Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.

  2012cites this paper
• Régulateurs de la protéostasie

  2012cites this paper
• Glutamatergic neurotransmission as molecular target of new anticonvulsants.

  2012cites this paper
• Synthesis of mono, bis-2-(2-arylideneaminophenyl) indole azomethines as potential antimicrobial agents

  2011cites this paper
• Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors.

  2011cites this paper
• Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase.

  2010cites this paper
• Insights into structure-activity relationships and CNS therapeutic applications of NR2B selective antagonists.

  2010cites this paper
• Combined Strategies for the Discovery of Ionotropic Glutamate Receptor Antagonists

  2009cites this paper
• Synthesis and Pharmacological Evaluation of New Indolyl-oxadiazoles as Anticonvulsant Agents

  2009cites this paper