Regulation of metalloproteinases and NF‐κB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA

No abstract is available for this paper.

• Publication year

  2004

• Venue

  British Journal of Pharmacology

• Publication date

  2004-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0705864PMID 15210577PMCID PMC1575112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

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  2003influential reference
• Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.

  2002cited by this paper
• Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.

  2002cited by this paper
• Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.

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• Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.

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• S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

  2002cited by this paper
• Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.

  2002cited by this paper
• Selective transduction of murine myelomonocytic leukemia cells (WEHI-3B) with regular and RGD-adenoviral vectors.

  2001cited by this paper
• Treatment of Elderly Patients with Nabumetone or Diclofenac: Gastrointestinal Safety Profile

  2001cited by this paper
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  2001cited by this paper
• Effect of nabumetone and aspirin on colonic mucosal bleeding time

  2001cited by this paper
• Pathogenesis of rheumatoid arthritis: the role of synoviocytes.

  2001cited by this paper
• Phosphatidylinositol 3‐kinase and ERK are required for NF‐κB activation but not for phagocytosis

  2001cited by this paper
• Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

  2001cited by this paper
• The p38 MAP kinase inhibitor SB203580 enhances nuclear factor‐kappa B transcriptional activity by a non‐specific effect upon the ERK pathway

  2000cited by this paper
• Peroxynitrite Targets the Epidermal Growth Factor Receptor, Raf-1, and MEK Independently to Activate MAPK*

  2000cited by this paper
• Inhibition of IκB Kinase Activity by Sodium Salicylate in Vitro Does Not Reflect Its Inhibitory Mechanism in Intact Cells*

  2000cited by this paper
• Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.

  2000cited by this paper
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  2000cited by this paper
• Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

  1999cited by this paper
• Regulation of nitric oxide and prostaglandin E2 production by CSAIDSTM (SB203580) in murine macrophages and bovine chondrocytes stimulated with LPS

  1999cited by this paper
• Cell Stress and MKK6b-mediated p38 MAP Kinase Activation Inhibit Tumor Necrosis Factor-induced IκB Phosphorylation and NF-κB Activation*

  1999cited by this paper
• Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

  1998cited by this paper
• Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes.

  1998cited by this paper
• NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

  1998cited by this paper
• Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.

  1998cited by this paper
• Clinical Pharmacokinetics of Diclofenac

  1997cited by this paper
• Role of Protein Kinase A in Collagenase‐1 Gene Regulation by Prostaglandin E1: Studies in a Rabbit Synoviocyte Cell Line, HIG‐82

  1997cited by this paper
• Clinical Pharmacokinetics of Nabumetone

  1997cited by this paper
• Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate (*)

  1996cited by this paper
• Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis.

  1996cited by this paper
• Crosstalk in signal transduction via EP receptors: prostaglandin E1 inhibits chemoattractant-induced mitogen-activated protein kinase activity in human neutrophils.

  1995cited by this paper
• SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

  1995cited by this paper
• Suppression of acute inflammation with liposome associated prostaglandin E1.

  1994cited by this paper
• Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils.

  1994cited by this paper
• Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway.

  1994cited by this paper
• Nabumetone: a clinical appraisal.

  1994cited by this paper
• Inhibition of NF-kappa B by sodium salicylate and aspirin.

  1994cited by this paper
• The unique pharmacologic profile of nabumetone.

  1992cited by this paper
• The unique pharmacologic profile of nabumetone.

  1992cited by this paper
• Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts.

  1992cited by this paper
• An overview of the clinical pharmacokinetics of nabumetone.

  1992cited by this paper
• An overview of the clinical pharmacokinetics of nabumetone.

  1992cited by this paper
• HIG-82: An established cell line from rabbit periarticular soft tissue, which retains the “activatable” phenotype

  1988cited by this paper
• Blood and Tissue Fluid Levels of a New Non-Steroidal Anti-Inflammatory Preparation of Nabumetone

  1987cited by this paper
• Metabolism of nabumetone (BRL 14777) by various species including man.

  1984cited by this paper
• Prostaglandine1 treatment of NZB/NZWF1 hybrid MICE

  1977cited by this paper
• Prostaglandin E1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis.

  1977cited by this paper
• Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

  1976influential reference
• Effect of prostaglandin E 1 on adjuvant arthritis.

  1971cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• From chronic gastritis to gastric cancer: Mendelian randomisation and multi-omics interrogation of leukaemia inhibitory factor receptor (LIFR), hepatocyte growth factor (HGF), serine protease inhibitor E1 (SERPINE1) and interleukin-10 receptor subunit beta (IL10RB).

  2025cites this paper
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  2016cites this paper
• A protocol for the culture and isolation of murine synovial fibroblasts

  2016cites this paper
• Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.

  2015cites this paper
• Cellular signals underlying β-adrenergic receptor mediated salivary gland enlargement.

  2012cites this paper
• Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis

  2011cites this paper
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  2009cites this paper
• The Anti-Inflammatory Effects of Prostaglandins

  2009influential citation
• Induction of chondrogenic phenotype in synovium-derived progenitor cells by intermittent hydrostatic pressure.

  2008cites this paper
• The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production.

  2008cites this paper
• Helicobacter pylori Stimulates Gastric Epithelial Cell MMP-1 Secretion via CagA-dependent and -independent ERK Activation*

  2007cites this paper
• Fractalkine is a novel chemoattractant for rheumatoid arthritis fibroblast-like synoviocyte signaling through MAP kinases and Akt.

  2007cites this paper
• Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.

  2007cites this paper
• Co-activation of synovial fibroblasts by laminin-111 and transforming growth factor-β induces expression of matrix metalloproteinases 3 and 10 independently of nuclear factor-κB

  2007cites this paper
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  2005cites this paper
• The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.

  2005cites this paper