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2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process

Jian Li,Wang He,Pan Lei,Jiacheng Song,Jiyou Huo,Hongbo Wei,H. Bai,W. Xie

Published 2021 in Synthetic Communications

ABSTRACT

Abstract A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsymmetric ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides Monuro and Isoproturon. Graphical Abstract

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