Introduction to the Special LDLensRad Focus Issue

Recent epidemiological and experimental animal data, as well as reanalyses of data previously accumulated, indicate that the lens of the eye is more radiosensitive than was previously thought. This has resulted in a reduction of the occupational lens dose limit within the European Union countries, Japan and elsewhere. This Commentary introduces the work done by the LDLensRad Consortium contained within this Focus Issue, towards advancement of understanding of the mechanisms of low dose radiation cataract.

• Publication year

  2021

• Venue

  Radiation Research

• Publication date

  2021-11-17

• Fields of study

  Medicine, Physics, Environmental Science

• Identifiers
  DOI 10.1667/RADE-21-00188.1PMID 34788470
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Keeping the ICRP recommendations fit for purpose

  2021cited by this paper
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• Complex Long-term Effects of Radiation on Adult Mouse Behavior

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• Lens Epithelial Cell Proliferation in Response to Ionizing Radiation

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• Radiation-Induced Lens Opacity and Cataractogenesis: A Lifetime Study Using Mice of Varying Genetic Backgrounds

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• miRNA-Signature of Irradiated Ptch1+/– Mouse Lens is Dependent on Genetic Background

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• Contribution of Genetic Background to the Radiation Risk for Cancer and Non-Cancer Diseases in Ptch1+/– Mice

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• Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/–) and Ercc2(+/–) Mutated Mice

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• Early Responses to Low-Dose Ionizing Radiation in Cellular Lens Epithelial Models

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• Radiation-induced lens opacities: Epidemiological, clinical and experimental evidence, methodological issues, research gaps and strategy.

  2020cited by this paper
• Report of IRPA task group on issues and actions taken in response to the change in eye lens dose limit

  2020cited by this paper
• Dose-dependent long-term effects of a single radiation event on behaviour and glial cells

  2020cited by this paper
• Outline of NCRP Report No. 180 “Management of Exposure to Ionizing Radiation: Radiation Protection Guidance for the United States”

  2019cited by this paper
• Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses.

  2019cited by this paper
• Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens

  2019cited by this paper
• Cataractogenic load - A concept to study the contribution of ionizing radiation to accelerated aging in the eye lens.

  2019cited by this paper
• γ-Crystallin redox–detox in the lens

  2018cited by this paper
• Seeing through a glass darkly and taking the next right steps

  2018cited by this paper
• Guidance on radiation dose limits for the lens of the eye: overview of the recommendations in NCRP Commentary No. 26

  2017cited by this paper
• Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research.

  2016cited by this paper
• ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

  2012cited by this paper

• Low-dose ionizing radiation: Effects on the proliferation and migration of lens epithelial cells via activation of the Wnt/β-catenin pathway.

  2023cites this paper
• Noncancer Effects of Ionizing Radiation Exposure on the Eye, the Circulatory System and beyond: Developments made since the 2011 ICRP Statement on Tissue Reactions

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• Risk factors for eye lens opacity in nuclear medicine workers – An overview

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• The Evidence for Excess Risk of Cancer and Non-Cancer Disease at Low Doses and Dose Rates

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• Age effects on radiation response: summary of a recent symposium and future perspectives

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• Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

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• Individual response of the ocular lens to ionizing radiation

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• Regulatory implementation of the occupational equivalent dose limit for the lens of the eye and underlying relevant efforts in Japan

  2022cites this paper