Observation of universal ageing dynamics in antibiotic persistence

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Nature

• Publication date

  2021-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41586-021-04114-wPMID 34789881
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Harnessing Machine Learning To Unravel Protein Degradation in Escherichia coli

  2020cited by this paper
• Predictive biology: modelling, understanding and harnessing microbial complexity

  2020cited by this paper
• Stability of gene regulatory networks

  2020cited by this paper
• Wide lag time distributions break a trade-off between reproduction and survival in bacteria

  2020cited by this paper
• Single-cell RNA-sequencing reports growth-condition-specific global transcriptomes of individual bacteria

  2020cited by this paper
• Biological Networks Regulating Cell Fate Choice Are Minimally Frustrated.

  2020cited by this paper
• In Vitro Studies of Persister Cells

  2020cited by this paper
• Definitions and guidelines for research on antibiotic persistence

  2019cited by this paper
• Prokaryotic Single-Cell RNA Sequencing by In Situ Combinatorial Indexing

  2019cited by this paper
• Microbial single-cell RNA sequencing by split-pool barcoding

  2019cited by this paper
• Persister Cells and Infectious Disease

  2019cited by this paper
• Power-law tail in lag time distribution underlies bacterial persistence

  2019cited by this paper
• Death Rate of E. coli during Starvation Is Set by Maintenance Cost and Biomass Recycling.

  2019cited by this paper
• Microfluidics and single-cell microscopy to study stochastic processes in bacteria.

  2018cited by this paper
• Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria

  2018cited by this paper
• A global resource allocation strategy governs growth transition kinetics of Escherichia coli

  2017cited by this paper
• Dual role of starvation signaling in promoting growth and recovery

  2017cited by this paper
• Bacterial persistence from a system-level perspective.

  2017cited by this paper
• SnapShot: Timescales in Cell Biology.

  2016cited by this paper
• Distinguishing between resistance, tolerance and persistence to antibiotic treatment

  2016cited by this paper
• Theory for transitions between exponential and stationary phases: universal laws for lag time

  2016cited by this paper
• The unforeseen challenge: from genotype-to-phenotype in cell populations

  2015cited by this paper
• Real-time metabolome profiling of the metabolic switch between starvation and growth

  2015cited by this paper
• Advanced methods of microscope control using μManager software.

  2014cited by this paper
• Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

  2014cited by this paper
• Recurrence-Based Information Processing in Gene Regulatory Networks

  2014cited by this paper
• Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics.

  2014cited by this paper
• Direct observation of single stationary-phase bacteria reveals a surprisingly long period of constant protein production activity

  2013cited by this paper
• Promoter activity dynamics in the lag phase of Escherichia coli

  2013cited by this paper
• Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in Staphylococcus aureus

  2013cited by this paper
• Age of Inoculum Strongly Influences Persister Frequency and Can Mask Effects of Mutations Implicated in Altered Persistence

  2011cited by this paper
• On relaxations and aging of various glasses

  2011cited by this paper
• Bacterial Stress Responses, Second Edition

  2011cited by this paper
• Automated imaging with ScanLag reveals previously undetectable bacterial growth phenotypes

  2010cited by this paper
• Single-Cell and Population Lag Times as a Function of Cell Age

  2008cited by this paper
• (p)ppGpp: still magical?

  2008cited by this paper
• Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge

  2007cited by this paper
• On the evolutionary origin of aging

  2007cited by this paper
• A classification based framework for quantitative description of large-scale microarray data

  2006cited by this paper
• Bacterial Persistence as a Phenotypic Switch

  2004cited by this paper
• Localization of denaturation bubbles in random DNA sequences

  2003cited by this paper
• Conditional senescence in bacteria: death of the immortals

  2003cited by this paper
• Random Boolean network models and the yeast transcriptional network

  2003cited by this paper
• Hierarchical Organization of Modularity in Metabolic Networks

  2002cited by this paper
• Measuring Equilibrium Properties in Aging Systems

  1998cited by this paper
• Role of guanosine tetraphosphate in gene expression and the survival of glucose or seryl-tRNA starved cells of Escherichia coli K12.

  1994cited by this paper
• The post-antibiotic effect.

  1993cited by this paper
• Analytical solution of the off-equilibrium dynamics of a long-range spin-glass model.

  1993cited by this paper
• Changes in viability, respiratory activity and morphology of the marine Vibrio sp. strain S14 during starvation of individual nutrients and subsequent recovery

  1993cited by this paper
• Weak ergodicity breaking and aging in disordered systems

  1992cited by this paper
• Chaos in random neural networks.

  1988cited by this paper
• Effects of reduced energy production on protein degradation, guanosine tetraphosphate, and RNA synthesis in Escherichia coli.

  1978cited by this paper
• Infinite-ranged models of spin-glasses

  1978cited by this paper
• The adaptive responses of Escherichia coli to a feast and famine existence.

  1971cited by this paper

• DEAD-box ATPase–marked condensates coordinate compartmentalized translation and antibiotic persistence

  2026cites this paper
• Induced tolerance to UV stress drives survival heterogeneity in isogenic E. coli cell populations

  2026cites this paper
• Differentiation between regulated and disrupted growth arrests allows tailoring of effective treatments for antibiotic persistence

  2026cites this paper
• Vaccination Gaps and Hepatitis B Prevalence among Pregnant Women in Bauchi State: A Call for Strengthened Immunization Efforts

  2025cites this paper
• Two‐Layer Droplet Arrays Enable Dynamic Manipulation of Cell Microenvironment During High‐Throughput Bacterial Cultivation

  2025cites this paper
• Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response

  2025cites this paper
• How nutrient starvation impacts the gut microbiome

  2025cites this paper
• Adaptation to extreme stress under the growth-survival fitness trade-off

  2025cites this paper
• A bacterial toxin-antitoxin system involved in an unusual response to genotoxic stress

  2025cites this paper
• Bacterial programmed cell death and toxin-antitoxin system in bacteria

  2025cites this paper
• Antibacterial activity and mechanism of novel phage endolysin lysSEP21 against dual-species biofilm of Salmonella and Escherichia coli and its application in food preservation.

  2025cites this paper
• Single-Cell Phenotypic Heterogeneity Shapes Quorum Signaling Dynamics in Pseudomonas aeruginosa

  2025cites this paper
• Route of Random Process to Ultraslow Aging Phenomena.

  2025cites this paper
• Rare-Event-Induced Ergodicity Breaking in Logarithmic Aging Systems

  2025cites this paper
• Perturbation-response analysis of in silico metabolic dynamics revealed hard-coded responsiveness in the cofactors and network sparsity

  2025cites this paper
• Triggered and Spontaneous Dormancy in Bacteria During Feast-Famine Cycles with Stochastic Antibiotic Application

  2025cites this paper
• What Is the Impact of Antibiotic Resistance Determinants on the Bacterial Death Rate?

  2025cites this paper
• Efficient treatment of heterogeneous malignant cell populations

  2025cites this paper
• Variability in Protein Expression and Fitness Under Stress: Distinct Modes of Early Adaptation of Populations

  2025cites this paper
• Universal sublinear population growth density dependence unrelated to resource limitation

  2025cites this paper
• Persister Cells Form Based on Low Ribosome Content

  2025cites this paper
• Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery

  2024cites this paper
• Simple bacterial growth model for the formation of spontaneous and triggered dormant subpopulations

  2024cites this paper
• Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms

  2024cites this paper
• Understanding Staphylococcus aureus internalisation and induction of antimicrobial tolerance

  2024cites this paper
• Singular effect of linkage on long-term genetic gain in Fisher’s infinitesimal model

  2024cites this paper
• Slow closure of Earth’s carbon cycle

  2024cites this paper
• A stochastic approach for modelling the in-vitro effect of osmotic stress on growth dynamics and persistent cell formation in Listeria monocytogenes.

  2024cites this paper
• The macrophage-bacterium mismatch in persister formation.

  2024cites this paper
• Tools and methods for high-throughput single-cell imaging with the mother machine

  2024cites this paper
• Emergent antibiotic persistence in a spatially structured synthetic microbial mutualism

  2024influential citation
• Implications of lytic phage infections inducing persistence.

  2024cites this paper
• Phenotypic resistant single-cell characteristics under recurring ampicillin antibiotic exposure in Escherichia coli

  2024cites this paper
• Bacterial persisters: molecular mechanisms and therapeutic development

  2024cites this paper
• Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update

  2024cites this paper
• Design of microbial catalysts for two-stage processes

  2024cites this paper
• Heat resistance of Listeria monocytogenes persistent cells following osmotic stress in cooked pork sausages

  2024cites this paper
• Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

  2024cites this paper
• Antibiotic heteroresistance and persistence: an additional aid in hospital acquired infections by Enterococcus spp.?

  2024cites this paper
• Toxin-mediated depletion of NAD and NADP drives persister formation in a human pathogen

  2024cites this paper
• Roles of network topology in the relaxation dynamics of simple chemical reaction network models

  2024cites this paper
• Exploring the antibiotic resistance of Listeria monocytogenes in food environments – a review

  2024cites this paper
• The Bro-Xre toxin-antitoxin modules in Weissella cibaria: inducing persister cells to escape tetracycline stress by disrupting metabolism

  2024cites this paper
• Effects of osmotic stress on Listeria monocytogenes ATCC 7644: persistent cells and heat resistance

  2023cites this paper
• Structured population balances to support microalgae-based processes: Review of the state-of-art and perspectives analysis

  2023cites this paper
• Single Cell Killing Kinetics Differentiate Phenotypic Bacterial Responses to Different Antibacterial Classes

  2023cites this paper
• Environmental, mechanistic and evolutionary landscape of antibiotic persistence

  2023cites this paper
• Bacterial memory in antibiotic resistance evolution and nanotechnology in evolutionary biology

  2023cites this paper
• Grow now, pay later: When should a bacterium go into debt?

  2023cites this paper
• A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

  2023cites this paper
• Universal Transitions between Growth and Dormancy via Intermediate Complex Formation.

  2023cites this paper
• Logarithmic aging via instability cascades in disordered systems

  2023cites this paper
• Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

  2023cites this paper
• Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

  2023influential citation
• Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma

  2023cites this paper
• Emerging single-cell microfluidic technology for microbiology

  2023cites this paper
• Tools and methods for high-throughput single-cell imaging with the mother machine

  2023influential citation
• Differential proteome diversification in yeast populations: modes of short-term adaptation and fitness outcomes

  2023cites this paper
• Microbial life in slow and stopped lanes.

  2023cites this paper
• Resuscitation dynamics reveal persister partitioning after antibiotic treatment

  2023cites this paper
• Advances in linking single-cell bacterial stress response to population-level survival.

  2023cites this paper
• Damage dynamics in single E. coli and the role of chance in the timing of cell death

  2023cites this paper
• Structural determinants of relaxation dynamics in chemical reaction networks

  2023cites this paper
• Single-cell phenotypic characteristics of phenotypic resistance under recurring antibiotic exposure in Escherichia coli

  2023cites this paper
• Damage dynamics and the role of chance in the timing of E. coli cell death

  2023cites this paper
• Absorption/Attenuation Spectral Description of ESKAPEE Bacteria: Application to Seeder-Free Culture Monitoring, Mammalian T-Cell and Bacteria Mixture Analysis and Contamination Description

  2023cites this paper
• Decline in nitrosative stress drives antibiotic persister regrowth during infection.

  2023cites this paper
• Antibiotic tolerance: targeting bacterial survival.

  2023cites this paper
• D R A F T Polar accumulation of pyoverdin facilitates rapid exit from stationary phase

  2023cites this paper
• Single-cell microfluidics enabled dynamic evaluation of drug combinations on antibiotic resistance bacteria.

  2023cites this paper
• Predictive Population Dynamics of Escherichia coli O157:H7 and Salmonella enterica on Plants: a Mechanistic Mathematical Model Based on Weather Parameters and Bacterial State

  2023cites this paper
• A Shift in Perspective: A Role for the Type I Toxin TisB as Persistence-Stabilizing Factor

  2022cites this paper
• Slow relaxation and aging in the model of randomly connected cycles network

  2022influential citation
• Forms of Bacterial Survival in Model Biofilms

  2022cites this paper
• Shaping bacterial gene expression by physiological and proteome allocation constraints

  2022cites this paper
• Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

  2022cites this paper
• Escherichia coli cells are primed for survival before lethal antibiotic stress

  2022cites this paper
• Studying antibiotic persistence in vivo using the model organism Salmonella Typhimurium.

  2022cites this paper
• Reply to Zhang et al.: The critical temperature dependence of developmental rates is in search of a mechanism

  2022cites this paper
• Bacteria grow swiftly and live thriftily.

  2022cites this paper
• Resonant learning in scale-free networks

  2021cites this paper
• Polar accumulation of pyoverdin and exit from stationary phase

  2021cites this paper
• A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide

  2021cites this paper
• Stress and disarray leading to persistence

  2021cites this paper
• Introduction: Trends, Puzzles, and Hopes for the Future of Healthcare

  year unknowncites this paper