Genetic and substrate-level modulation of Bacillus subtilis physiology for enhanced extracellular human interferon gamma production

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Preparative Biochemistry & Biotechnology

• Publication date

  2018-04-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/10826068.2018.1446157PMID 29688129
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is Pichia pastoris a realistic platform for industrial production of recombinant human interferon gamma?

  2017influential reference
• Current prospects of type II interferon γ signaling and autoimmunity

  2017cited by this paper
• Codon influence on protein expression in E. coli correlates with mRNA levels

  2016cited by this paper
• Translation elicits a growth rate‐dependent, genome‐wide, differential protein production in Bacillus subtilis

  2016cited by this paper
• Improving the production of human interferon gamma (hIFN-γ) in Pichia pastoris cell factory: An approach of cell level

  2016cited by this paper
• Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation.

  2016cited by this paper
• Improving Protein Production on the Level of Regulation of both Expression and Secretion Pathways in Bacillus subtilis.

  2015cited by this paper
• Bacterial growth: global effects on gene expression, growth feedback and proteome partition.

  2014cited by this paper
• Cloning, characterization, and production of a novel lysozyme by different expression hosts.

  2014cited by this paper
• Improving the Expression of Recombinant Proteins in E. coli BL21 (DE3) under Acetate Stress: An Alkaline pH Shift Approach

  2014cited by this paper
• Expression, purification and characterization of human interferon-γ in Pichia pastoris.

  2014cited by this paper
• Amino acid misincorporation in recombinant biopharmaceutical products.

  2014cited by this paper
• The metabolic potential of Escherichia coli BL21 in defined and rich medium

  2014influential reference
• Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: The effect of carbon source and CO2 partial pressure

  2013cited by this paper
• Bacillus subtilis: from soil bacterium to super-secreting cell factory

  2013cited by this paper
• Overproduction of a thermostable 4-α-glucanotransferase by codon optimization at N-terminus region.

  2013influential reference
• Authentic human basic fibroblast growth factor produced by secretion in Bacillus subtilis

  2012cited by this paper
• Production of soluble recombinant proteins in Escherichia coli: effects of process conditions and chaperone co-expression on cell growth and production of xylanase.

  2012cited by this paper
• An efficient transformation method for Bacillus subtilis DB104

  2012influential reference
• Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy

  2011cited by this paper
• Secretion of biologically-active human interferon-β by Bacillus subtilis

  2011cited by this paper
• Propeptide of Bacillus subtilis amylase enhances extracellular production of human interferon-α in Bacillus subtilis

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• Comparison of two codon optimization strategies to enhance recombinant protein production in Escherichia coli

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• Analysis and application of Bacillus subtilis sortases to anchor recombinant proteins on the cell wall

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• Enhancement of Human γ-Interferon Production in Recombinant E. coli Using Batch Cultivation

  2010cited by this paper
• Replicative and integrative plasmids for production of human interferon gamma in Bacillus subtilis.

  2010influential reference
• Kinetic studies of recombinant human interferon-gamma expression in continuous cultures of E. coli

  2009cited by this paper
• METHODS: Optimization of culture medium for production of recombinant dengue protein in Escherichia coli

  2009cited by this paper
• Folding at the rhythm of the rare codon beat

  2008cited by this paper
• CAIcal: A combined set of tools to assess codon usage adaptation

  2008cited by this paper
• Periplasmic expression and recovery of human interferon gamma in Escherichia coli.

  2008cited by this paper
• Enhanced Bacterial Protein Expression During Auto‐Induction Obtained by Alteration of Lac Repressor Dosage and Medium Composition

  2008cited by this paper
• The Vienna RNA Websuite

  2008cited by this paper
• Dark proteins: Effect of inclusion body formation on quantification of protein expression

  2008cited by this paper
• Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium.

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• Expression Vectors for the Rapid Purification of Recombinant Proteins in Bacillus subtilis

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• Extracellular Expression of a Functional Recombinant Ganoderma lucidium Immunomodulatory Protein by Bacillus subtilis and Lactococcus lactis

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• Modified penicillin acylase signal peptide allows the periplasmic production of soluble human interferon-γ but not of soluble human interleukin-2 by the Tat pathway in Escherichia coli

  2007cited by this paper
• An Improved Implementation of Codon Adaptation Index

  2007cited by this paper
• Production of recombinant proteins in Bacillus subtilis.

  2007influential reference
• Increased yield of high purity recombinant human interferon-gamma utilizing reversed phase column chromatography.

  2007cited by this paper
• Microbial Cell Factories BioMed Central Review

  2007cited by this paper
• Novel plasmid-based expression vectors for intra- and extracellular production of recombinant proteins in Bacillus subtilis.

  2006cited by this paper
• The relationship among gene expression, folding free energy and codon usage bias in Escherichia coli

  2005cited by this paper
• Growing E. coli to high cell density--a historical perspective on method development.

  2005cited by this paper
• The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria.

  2005influential reference
• Process development for production of recombinant human interferon-γ expressed in Escherichia coli

  2004cited by this paper
• Transport capabilities encoded within the Bacillus subtilis genome.

  2002cited by this paper
• Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from Bacillus subtilis: Effects of Molecular Chaperones and a Wall-Bound Protease on Antibody Fragment Production

  2002cited by this paper
• Enzymatic Manipulation of DNA and RNA

  2002cited by this paper
• Metabolic Network Analysis for Human Therapeutic Protein Productions: Effects of the P/O Ratio

  2001cited by this paper
• Carbon sources affect metabolic capacities of Bacillus species for the production of industrial enzymes: theoretical analyses for serine and neutral proteases and alpha-amylase.

  2001cited by this paper
• Control Strategies for High-Cell Density Cultivation of Escherichia coli

  2000cited by this paper
• Codon usage tabulated from international DNA sequence databases: status for the year 2000

  2000influential reference
• Mucosa-Specific Targets for Regulation of IFN-γ Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-γ Expression1

  2000influential reference
• Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure.

  1999cited by this paper
• Complete suboptimal folding of RNA and the stability of secondary structures.

  1999cited by this paper
• Codon usage and lateral gene transfer in Bacillus subtilis.

  1999cited by this paper
• CHAPTER 1 – The Essence of Metabolic Engineering

  1998cited by this paper
• Construction of an efficient Bacillus subtilis system for extracellular production of heterologous proteins.

  1998cited by this paper
• Recombinant interferon gamma for treatment of chronic granulomatous disease and other disorders.

  1992cited by this paper
• Recombinant interferon gamma for treatment of chronic granulomatous disease and other disorders.

  1992cited by this paper
• Effects of nutritional conditions on plasmid stability and production of tryptophan synthase by a recombinant Escherichia coli.

  1990cited by this paper
• The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.

  1987cited by this paper
• A promoter for Bacillus subtilis expression vector.

  1985cited by this paper

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