Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Trace Elements in Medicine and Biology

• Publication date

  2015-07-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.jtemb.2015.04.002PMID 26004900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protective Effect of Selenium Against Aluminum Chloride-Induced Alzheimer’s Disease: Behavioral and Biochemical Alterations in Rats

  2015cited by this paper
• Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.

  2014cited by this paper
• Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review.

  2014cited by this paper
• The effects of valsartan on cognitive deficits induced by aluminum trichloride and d-galactose in mice

  2014cited by this paper
• Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.

  2014cited by this paper
• Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats

  2013cited by this paper
• Object recognition test in mice

  2013cited by this paper
• Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway.

  2013cited by this paper
• Fisetin Enhances Behavioral Performances and Attenuates Reactive Gliosis and Inflammation During Aluminum Chloride-Induced Neurotoxicity

  2013cited by this paper
• Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function☆

  2013cited by this paper
• Aluminium, carbonyls and cytokines in human nipple aspirate fluids: Possible relationship between inflammation, oxidative stress and breast cancer microenvironment.

  2013cited by this paper
• Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice.

  2013cited by this paper
• Location in Query / Remark : click on the Q link to go

  2013cited by this paper
• Therapeutic Potential of the Natural Product Mangiferin in Metabolic Syndrome

  2013cited by this paper
• Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

  2012cited by this paper
• Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats

  2011cited by this paper
• Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats.

  2010cited by this paper
• Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction.

  2009cited by this paper
• Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment

  2009cited by this paper
• Mangiferin ameliorates scopolamine-induced learning deficits in mice.

  2009cited by this paper
• Brain lesions comprised of aluminum-rich cells that lack microtubules may be associated with the cognitive deficit of Alzheimer's disease.

  2009cited by this paper
• Effect of N-acetyl cysteine against aluminium-induced cognitive dysfunction and oxidative damage in rats.

  2009cited by this paper
• Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction

  2009cited by this paper
• Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice.

  2008cited by this paper
• Reviews: BDNF and Memory Formation and Storage

  2008cited by this paper
• by Institute of Pharmacology Polish Academy of Sciences

  2008cited by this paper
• Aluminium and lead: molecular mechanisms of brain toxicity

  2008cited by this paper
• Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells.

  2007cited by this paper
• Morris water maze: procedures for assessing spatial and related forms of learning and memory

  2006cited by this paper
• A new insight on Al-maltolate-treated aged rabbit as Alzheimer's animal model.

  2006cited by this paper
• Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate.

  2005cited by this paper
• Spatial memory, recognition memory, and the hippocampus.

  2004cited by this paper
• The pro-oxidant activity of aluminum.

  2004cited by this paper
• Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice.

  2004cited by this paper
• Brain-derived neurotrophic factor protects cultured rat hippocampal neurons from aluminum maltolate neurotoxicity.

  2003cited by this paper
• Aluminum disrupts the pro-inflammatory cytokine/neurotrophin balance in primary brain rotation-mediated aggregate cultures: possible role in neurodegeneration.

  2003cited by this paper
• Mangifera indica L.

  2003cited by this paper
• Neurotoxic effects of aluminium among foundry workers and Alzheimer's disease.

  2002cited by this paper
• Brain uptake, retention, and efflux of aluminum and manganese.

  2002cited by this paper
• RETRACTED: Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits

  2001cited by this paper
• Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.

  2001cited by this paper
• Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain

  2001cited by this paper
• Entry, half-life, and desferrioxamine-accelerated clearance of brain aluminum after a single (26)Al exposure.

  2001cited by this paper
• An aluminum-induced increase in GFAP is attenuated by some chelators.

  1998cited by this paper
• Determination of nitrite/nitrate in human biological material by the simple Griess reaction.

  1998cited by this paper
• Neurologic syndrome in 25 workers from an aluminum smelting plant.

  1992cited by this paper
• Effect of exposure of miners to aluminium powder.

  1990cited by this paper
• Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts.

  1985cited by this paper
• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

  1982cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Improved method for the determination of blood glutathione.

  1963cited by this paper
• A new and rapid colorimetric determination of acetylcholinesterase activity.

  1961cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Dietary Isoflavone Biochanin A Attenuates Aluminium Chloride-Induced Sporadic Alzheimer’s Disease and Associated Neurobehavioral Alterations Through NRF2-HO1 Pathway Activation and NLRP3 Inflammasome Suppression

  2026cites this paper
• Anemarrhenae rhizoma water extract (AWE) ameliorates learning and memory impairments by activating the ADAM17/Aph-1-Notch signaling axis and restoring synaptic protein loss.

  2026cites this paper
• Mangiferin Alleviates Formaldehyde‐Induced Tau Hyperphosphorylation and Cognitive Impairment in Mice via the PI3K/AKT/GSK3β Pathway: Insights From Network Pharmacology and Experimental Validation

  2026cites this paper
• Xanthones as Neuroprotective Agents: A Comprehensive Review of Their Role in the Prevention and Treatment of Neurodegenerative Diseases.

  2025cites this paper
• Mangiferin: A natural neuroprotective polyphenol with anti-inflammatory and anti-oxidant properties for depression.

  2025cites this paper
• In Vitro Antibacterial Activity of Pure and Encapsulated Mangiferin Against ESKAPE Bacteria

  2025cites this paper
• Systematic Analysis to Explore the Multiple Bioactive Ingredients and Mechanisms of Bupleurum Chinense DC. for Treating Neurodegenerative Diseases

  2025cites this paper
• Acute Supplementation of Soluble Mango Leaf Extract (Zynamite® S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

  2025influential citation
• In-Depth Analysis of Mangiferin and Its Formulations for Alleviating Neurodegenerative Diseases: A Comprehensive Review.

  2025cites this paper
• Cornus mas ameliorates AlCl3-induced Alzheimer’s disease in rats with metabolic syndrome by regulating inflammation and oxidative stress

  2025cites this paper
• The Neuroprotective Effects of Cyanidin Derivatives on AlCl3-Induced Zebrafish Model of Alzheimer’s Disease

  2025cites this paper
• Polyphenolic protection: the role of mangiferin in mitigating neurodegeneration and neuroinflammation

  2025cites this paper
• Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities

  2024cites this paper
• The effect of azelaic acid on AlCl3-induced neurocognitive impairments and molecular changes in the hippocampus of rats.

  2024cites this paper
• Rosiridin Protects Against Aluminum Chloride-Induced Memory Impairment via Modulation of BDNF/NFκB/PI3K/Akt Pathway in Rats

  2024cites this paper
• Mangiferin activates the nuclear factor erythroid 2‐related factor pathway to protect SOD1‐G93A induced NSC‐34 motor neurons from oxidative stress and apoptosis

  2024cites this paper
• The Effect of Trientine on Alcl 3 -Induced Cognitive Dysfunction and Biochemical Changes in the Hippocampus of Rats

  2024cites this paper
• Acute effects of mango leaf extract on cognitive function in healthy adults: a randomised, double-blind, placebo-controlled crossover study

  2024cites this paper
• In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin

  2023cites this paper
• A supercritical fluid co-extract of turmeric powder and dried coconut shreds shows neuroprotection against AlCl3-induced Alzheimer's disease in rats through nose to brain delivery.

  2023cites this paper
• Development and evaluation of polysorbate-80 coated Mangiferin PLGA nanoparticles used in the treatment of cerebral ischemia

  2023cites this paper
• Neuroprotection against Aluminum Chloride-Induced Hippocampus Damage in Albino Wistar Rats by Leucophyllum frutescens (Berl.) I.M. Johnst. Leaf Extracts: A Detailed Insight into Phytochemical Analysis and Antioxidant and Enzyme Inhibition Assays.

  2023cites this paper
• Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

  2023influential citation
• C–Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells

  2023cites this paper
• Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms

  2023cites this paper
• Neuroprotective effect of Quercetin Nanoparticles: A possible prophylactic effect in cerebellar neurodegenerative disordersq.

  2023cites this paper
• The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment

  2023cites this paper
• Mangiferin depresses vesicular glutamate release in synaptosomes from the rat cerebral cortex by decreasing synapsin I phosphorylation.

  2023cites this paper
• Neuro-amelioration of Ficus lyrata (fiddle-leaf fig) extract conjugated with selenium nanoparticles against aluminium toxicity in rat brain: relevance to neurotransmitters, oxidative, inflammatory, and apoptotic events

  2023influential citation
• Comprehensive Profiling of Mangiferin Metabolites In Vivo and In Vitro Based on the “Drug Metabolite Clusters” Analytical Strategy

  2023cites this paper
• Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer’s disease

  2022cites this paper
• Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways

  2022cites this paper
• Natural activators of AMPK signaling: potential role in the management of type-2 diabetes

  2022cites this paper
• Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property

  2022cites this paper
• Neuroprotective Efficacy of Edaravone against Arsenic-Induced Behavioral and Neurochemical Deficits in Rats: Amelioration of Cholinergic and Mitochondrial Functions.

  2022cites this paper
• Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

  2022cites this paper
• Aluminum in food and potential role on Alzheimer’s disease of aluminum

  2021cites this paper
• Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

  2021cites this paper
• Neuropharmacological studies of ethanolic extract of Vaccinium corymbosum on Alzheimer’s type dementia and catatonia in Swiss albino mice

  2021cites this paper
• Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms.

  2021cites this paper
• Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals.

  2021cites this paper
• Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies.

  2021cites this paper
• SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells.

  2021cites this paper
• Aluminum chloride impairs learning and memory by P2X7 and A2A-receptor stimulations in hippocampus of mice

  2021cites this paper
• The Protection of Lactic Acid Bacteria Fermented-Mango Peel against Neuronal Damage Induced by Amyloid-Beta

  2021cites this paper
• A REVIEW ON THE RELATIONSHIP BETWEEN ALUMINUM CONTENT OF FOOD AND ALZHEIMER'S

  2021cites this paper
• Neuroprotective effect of Bryophyllum pinnatum flavonoids against aluminum chloride-induced neurotoxicity in rats

  2021cites this paper
• Neuroprotective and acetylcholinesterase inhibitory activity of plumbagin in ICV-LPS induced behavioral deficits in rats

  2021cites this paper
• Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals

  2020cites this paper
• Centella asiatica prevents D-galactose-Induced cognitive deficits, oxidative stress and neurodegeneration in the adult rat brain

  2020cites this paper
• Cassia tora extract alleviates Aβ1–42 aggregation processes in vitro and protects against aluminium‐induced neurodegeneration in rats

  2020cites this paper
• 7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence

  2020cites this paper
• Potential Neuroprotective Effect of Clopidogrel on Aluminum Chloride-Induced Alzheimer Disease in Rats

  2020cites this paper
• Mangiferin ameliorates intracerebroventricular-quinolinic acid-induced cognitive deficits, oxidative stress, and neuroinflammation in Wistar rats

  2020cites this paper
• Therapeutic Potential of Mangiferin in the Treatment of Various Neuropsychiatric and Neurodegenerative Disorders.

  2020cites this paper
• Protective effect of mangiferin on memory impairment: A systematic review

  2020cites this paper
• The multifaceted role of mangiferin in health and diseases: a review

  2020cites this paper
• Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

  2020cites this paper
• Central nervous system activities of extract Mangifera indica L.

  2020cites this paper
• Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-κB and Nrf2

  2019cites this paper
• Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models.

  2019cites this paper
• Neuroprotective effect of against aluminium-induced Gracilaria corticata neurotoxicity in the hippocampus and cerebral cortex of rat brain: Biochemical and histological approach

  2019cites this paper
• Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

  2019cites this paper
• Egg White Hydrolysate as a functional food ingredient to prevent cognitive dysfunction in rats following long-term exposure to aluminum

  2019cites this paper
• Overview of pharmacological research activities in North Eastern states of India in last 5 years

  2018cites this paper
• Hair Trace Elements in Overweight and Obese Adults in Association with Metabolic Parameters

  2018cites this paper
• Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer's disease.

  2018cites this paper
• Toxic metal(loid)‐based pollutants and their possible role in autism spectrum disorder

  2018cites this paper
• Efecto del liofilizado de hojas de Mangifera indica L. “mango kent” sobre memoria espacial y la lipoperoxidación en membranas neuronales de Rattus norvegicus Sprague Dawley ovariectomizadas

  2018cites this paper
• The effect of dietary pectins on object recognition memory, depression-like behaviour, and il-6 in mouse hippocampi

  2018cites this paper
• Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1

  2018cites this paper
• Voluntary alcohol consumption exacerbated high fat diet-induced cognitive deficits by NF-κB-calpain dependent apoptotic cell death in rat hippocampus: Ameliorative effect of melatonin.

  2018cites this paper
• Aluminum trichloride-induced hippocampal inflammatory lesions are associated with IL-1β-activated IL-1 signaling pathway in developing rats.

  2018cites this paper
• Alcohol aggravates stress-induced cognitive deficits and hippocampal neurotoxicity: Protective effect of melatonin.

  2017cites this paper
• Beneficial effect of Mangiferin against sleep deprivation-induced neurodegeneration and memory impairment in mice

  2017influential citation
• Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation

  2017cites this paper
• Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity

  2017cites this paper
• Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus

  2017cites this paper
• Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

  2017cites this paper
• Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

  2017cites this paper
• Aluminum exposure for 60days at an equivalent human dietary level promotes peripheral dysfunction in rats.

  2017cites this paper
• Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice

  2017cites this paper
• Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

  2016cites this paper
• Mangiferin inhibits macrophage classical activation via downregulating interferon regulatory factor 5 expression

  2016cites this paper
• Simultaneous determination of mangiferin and neomangiferin in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study.

  2016cites this paper
• Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation

  2016cites this paper
• Edaravone alleviates cisplatin-induced neurobehavioral deficits via modulation of oxidative stress and inflammatory mediators in the rat hippocampus.

  2016cites this paper
• Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice.

  2016cites this paper
• Aluminum Exposure at Human Dietary Levels for 60 Days Reaches a Threshold Sufficient to Promote Memory Impairment in Rats

  2016cites this paper
• The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects

  2016cites this paper
• NEUROTHERAPEUTIC EFFECT OF MANGIFERIN AGAINST HYPOXIC–ISCHEMIC ENCEPHALOPATHY IN NEONATAL RATS

  2016cites this paper
• AlCl3 induced neuroinflammation and excitotoxicity in brain AlCl3 induced neuroinflammation and excitotoxicity in brain striatum mediated memory and motor dysfunction ameliorated striatum mediated memory and motor dysfunction ameliorated via scopoletin enriched Canscora decussata extract via scopole

  year unknowncites this paper