Roles of ribosomal proteins in hematologic disorders and cancers: a review

Abstract Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation. In addition, ribosomal proteins also perform extra-ribosomal functions, such as participating in DNA replication, transcription, and damage repair, regulating cell growth, proliferation, apoptosis, and transformation. In recent years, studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases, including Diamond-Blackfan anemia, 5q-syndrome, Shwachman-Diamond syndrome, and other blood system diseases. Moreover, abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors. In this review, we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal, prostate, gastric, esophageal, and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers.

• Publication year

  2021

• Venue

  Emergency and Critical Care Medicine

• Publication date

  2021-12-07

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1097/EC9.0000000000000014
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• High RPS3A expression correlates with low tumor immune cell infiltration and unfavorable prognosis in hepatocellular carcinoma patients.

  2020cited by this paper
• Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5-FU

  2020cited by this paper
• DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3

  2020cited by this paper
• Research Progress of Ribosome Biogenesis and Cancer

  2020cited by this paper
• Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol-associated hepatocellular carcinoma using weighted gene co-expression network analysis

  2020cited by this paper
• Diamond-Blackfan Anemia

  2019cited by this paper
• Ribosomal Protein L15 is involved in Colon Carcinogenesis

  2019cited by this paper
• Identification of candidate diagnostic and prognostic biomarkers for human prostate cancer: RPL22L1 and RPS21

  2019cited by this paper
• Identification of key genes and pathways involved in microsatellite instability in colorectal cancer

  2019cited by this paper
• RPL34-AS1 functions as tumor suppressive lncRNA in esophageal cancer.

  2019cited by this paper
• Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond–like features

  2017cited by this paper
• Ribosome biogenesis and cancer.

  2017cited by this paper
• Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome

  2017cited by this paper
• Ribosome biogenesis in cancer: new players and therapeutic avenues

  2017cited by this paper
• Acquired ribosomopathies in leukemia and solid tumors.

  2017cited by this paper
• Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells.

  2017cited by this paper
• [Disorders of Ribosomal Proteins and Related Hematologic Diseases -Review].

  2016cited by this paper
• The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.

  2015cited by this paper
• Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia

  2014cited by this paper
• A new system for naming ribosomal proteins.

  2014cited by this paper
• A Novel Ribosomopathy Caused by Dysfunction of RPL10 Disrupts Neurodevelopment and Causes X-Linked Microcephaly in Humans

  2014cited by this paper
• Evaluation of immunogenicity and protective efficacy of a plasmid DNA vaccine encoding ribosomal protein L9 of Brucella abortus in BALB/c mice.

  2014cited by this paper
• Nucleolar stress in Diamond Blackfan anemia pathophysiology.

  2014cited by this paper
• The Tumor Suppressor rpl36 Restrains KRASG12V-Induced Pancreatic Cancer

  2014cited by this paper
• Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

  2013cited by this paper
• Ribosomal Protein S14 Negatively Regulates c-Myc Activity*

  2013cited by this paper
• Crystal structure of the 80S yeast ribosome.

  2012cited by this paper
• Alterations in the ribosomal machinery in cancer and hematologic disorders

  2012cited by this paper
• One core, two shells: bacterial and eukaryotic ribosomes

  2012cited by this paper
• Nucleolar Trafficking of the Mouse Mammary Tumor Virus Gag Protein Induced by Interaction with Ribosomal Protein L9

  2012cited by this paper
• siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer

  2011cited by this paper
• RPL36 as a prognostic marker in hepatocellular carcinoma

  2011cited by this paper
• Eukaryotic 5S rRNA biogenesis

  2011cited by this paper
• Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome.

  2011cited by this paper
• Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5′ terminal oligopyrimidine tract

  2011cited by this paper
• Dyskeratosis congenita: a combined immunodeficiency with broad clinical spectrum – a single‐center pediatric experience

  2011cited by this paper
• Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

  2010cited by this paper
• Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.

  2010cited by this paper
• Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations

  2010cited by this paper
• Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells.

  2010cited by this paper
• RPS2: a novel therapeutic target in prostate cancer

  2009cited by this paper
• A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q− syndrome

  2009cited by this paper
• Bone marrow cells from patients with Shwachman‐Diamond syndrome abnormally express genes involved in ribosome biogenesis and RNA processing

  2009cited by this paper
• Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1

  2009cited by this paper
• Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

  2009cited by this paper
• How common are extraribosomal functions of ribosomal proteins?

  2009cited by this paper
• Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy

  2008cited by this paper
• Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

  2008cited by this paper
• Ribosomal dysfunction and inherited marrow failure

  2008cited by this paper
• Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia.

  2008cited by this paper
• Human RPS 19 , the gene mutated in Diamond-Blackfan anemia , encodes a ribosomal protein required for the maturation of 40 S ribosomal subunits

  2007cited by this paper
• The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.

  2007cited by this paper
• Ribosomal protein S17 gene (RPS17) is mutated in Diamond‐Blackfan anemia

  2007cited by this paper
• Ribosomal proteins and colorectal cancer.

  2007cited by this paper
• Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

  2007influential reference
• Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits.

  2007cited by this paper
• Dyskeratosis congenita: a genetic disorder of many faces

  2007cited by this paper
• Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia.

  2006cited by this paper
• Alteration of RPL14 in squamous cell carcinomas and preneoplastic lesions of the esophagus.

  2006cited by this paper
• Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.

  2006cited by this paper
• Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer

  2006cited by this paper
• Ribosomal Protein L19 Is a Prognostic Marker for Human Prostate Cancer

  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• Correlation of 30S ribosomal proteins ofEscherichia coli isolated in different laboratories

  2004cited by this paper
• Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.

  2004cited by this paper
• Mutations in SBDS are associated with Shwachman–Diamond syndrome

  2003cited by this paper
• Differential Expression of Ribosomal Proteins in Human Normal and Neoplastic Colorectum

  2003cited by this paper
• Making ribosomes.

  2002cited by this paper
• Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro.

  2002cited by this paper
• Overexpression of B-type cyclins alters chromosomal segregation

  2002cited by this paper
• Gene transfer improves erythroid development in ribosomal protein S19-deficient Diamond-Blackfan anemia.

  2002cited by this paper
• The World Health Organization (WHO) classification of the myeloid neoplasms.

  2002cited by this paper
• Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma.

  2001cited by this paper
• Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia.

  2001cited by this paper
• Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer.

  2001cited by this paper
• N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

  2001cited by this paper
• The human ribosomal protein L6 gene in a critical region for Noonan syndrome

  2000cited by this paper
• X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

  1998cited by this paper
• Diamond-Blackfan anaemia: genetic homogeneity for a gene on chromosome 19q13 restricted to 1.8 Mb

  1997cited by this paper
• A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.

  1997cited by this paper
• Bone marrow transplantation in cartilage-hair hypoplasia: Correction of the immunodeficiency but not of the chondrodysplasia

  1996cited by this paper
• Extraribosomal functions of ribosomal proteins.

  1996cited by this paper
• Structure and evolution of mammalian ribosomal proteins.

  1995cited by this paper
• Implication of Mammalian Ribosomal Protein S3 in the Processing of DNA Damage (*)

  1995cited by this paper
• Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.

  1992cited by this paper
• Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein

  1991cited by this paper
• Letter to Blood To the editor: Biallelic mutations in DNAJC21 cause Shwachman-Diamond syndrome

  year unknowncited by this paper

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  2025cites this paper