Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD

The thymus ensures immune tolerance by synchronizing thymocyte development and selection. Alawam et al. show that a functional uncoupling of these events occurs after bone marrow transplantation, which results in post-transplant tolerance loss and autoimmunity caused by selective failures in thymus medulla regeneration.

• Publication year

  2021

• Venue

  Journal of Experimental Medicine

• Publication date

  2021-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20211239PMID 34910105PMCID 8679781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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