Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.1998.275.4.E618PMID 9755080
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation and activation of p70s6k by PDK1.

  1998cited by this paper
• Mechanisms and consequences of activation of protein kinase B/Akt.

  1998cited by this paper
• SIGNAL TRANSDUCTION: Lipid-Regulated Kinases: Some Common Themes at Last

  1998cited by this paper
• RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

  1998cited by this paper
• Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

  1997cited by this paper
• Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

  1997cited by this paper
• Akt Signaling--Linking Membrane Events to Life and Death Decisions

  1997cited by this paper
• Phosphoinositide 3-kinases: a conserved family of signal transducers.

  1997cited by this paper
• Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.

  1997cited by this paper
• p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase.

  1997cited by this paper
• The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

  1997cited by this paper
• Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells*

  1997cited by this paper
• The modular phosphorylation and activation of p70s6k

  1997cited by this paper
• Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways.

  1997cited by this paper
• Using structure to define the function of phosphoinositide 3‐kinase family members

  1997cited by this paper
• Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase*

  1996cited by this paper
• Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

  1996cited by this paper
• Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

  1996cited by this paper
• Protein Kinase Signaling Pathway Triggered by Cell Swelling and Involved in the Activation of Glycogen Synthase and Acetyl-CoA Carboxylase in Isolated Rat Hepatocytes*

  1996cited by this paper
• Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells*

  1996cited by this paper
• Phosphoinositide kinases.

  1996cited by this paper
• p70 S6 kinase: an enigma with variations.

  1996cited by this paper
• The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

  1995cited by this paper
• The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling.

  1995cited by this paper
• Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

  1995cited by this paper
• When is a lipid kinase not a lipid kinase? When it is a protein kinase.

  1995cited by this paper
• Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

  1995cited by this paper
• The Insulin-dependent Biosynthesis of GLUT1 and GLUT3 Glucose Transporters in L6 Muscle Cells Is Mediated by Distinct Pathways

  1995cited by this paper
• PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

  1995cited by this paper
• Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

  1995cited by this paper
• Rapamycin, Wortmannin, and the Methylxanthine SQ20006 Inactivate p70s6k by Inducing Dephosphorylation of the Same Subset of Sites (*)

  1995cited by this paper
• Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase.

  1995cited by this paper
• PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

  1994cited by this paper
• Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

  1994cited by this paper
• Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

  1994cited by this paper
• A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

  1994cited by this paper
• Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

  1993cited by this paper
• Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain.

  1992cited by this paper
• Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells.

  1992cited by this paper
• Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

  1992cited by this paper
• An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

  1992cited by this paper
• Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

  1992cited by this paper
• Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells.

  1991cited by this paper
• EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity.

  1989cited by this paper
• Assays of protein kinase.

  1983cited by this paper
• [1] Assays of protein kinase

  1983cited by this paper

• Contrasting views on the role of AMPK in autophagy

  2024cites this paper
• Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

  2019cites this paper
• Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion.

  2017cites this paper
• An overview of technical considerations for Western blotting applications to physiological research

  2017cites this paper
• adipocytesced insulin resistance in 3T3-L1

  2016cites this paper
• The insulin signalling pathway in skeletal muscle : in silico and in vitro

  2015cites this paper
• Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle.

  2014cites this paper
• Exercise and type 1 diabetes (T1DM).

  2013cites this paper
• Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells

  2012cites this paper
• INTENSITY OF SWIMMING EXERCISE AS CHRONIC STRESS INDUCTION TOWARDS EXPRESSION OF GLUCOSE TRANSPORTER 1 (GLUT1) IN BRAIN CAPILLARY ENDOTHELIAL OF RATS (Rattus norvegicus)

  2012cites this paper
• Ex Vivo Enzymatic Treatment of Aged CD4 T Cells Restores Cognate T Cell Helper Function and Enhances Antibody Production in Mice

  2012cites this paper
• in Mice Function and Enhances Antibody Production T Cells Restores Cognate T Cell Helper Ex Vivo Enzymatic Treatment of Aged CD4

  2012cites this paper
• Tissue specificity on insulin action and resistance: past to recent mechanisms

  2011cites this paper
• Study on glucose transport in muscle cells by extracts from Mitragyna speciosa (Korth) and mitragynine

  2011cites this paper
• Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms

  2011cites this paper
• Effect of Tinospora crispa on glucose uptake in skeletal muscle: role of glucose transporter 1 expression and extracellular signal-regulated kinase1/2 activation

  2011cites this paper
• Experimental models of HD and reflection on therapeutic strategies.

  2011cites this paper
• Astragaloside IV improved insulin resistance in L6 myotubes induced by high glucose and insulin

  2011cites this paper
• Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

  2010cites this paper
• Apoptosis en Adipocitos Marrones: Implicación en Obesidad y Cáncer

  2009cites this paper
• TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.

  2008cites this paper
• The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.

  2008cites this paper
• Huntington ’ s disease : progress and potential in the fi eld

  2007cites this paper
• Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes.

  2007cites this paper
• Regulatory binding partners and complexes of NHE3.

  2007cites this paper
• Huntington's disease: progress and potential in the field

  2007cites this paper
• Neuronal macroautophagy: from development to degeneration.

  2006cites this paper
• Role of the water extract from Coccinia indica stem on the stimulation of glucose transport in L8 myotubes

  2006cites this paper
• Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

  2005cites this paper
• The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

  2005cites this paper
• Preincubation with sodium ascorbate potentiates insulin-dependent PKB/Akt and c-Jun phosphorylation in L6 rat myoblasts challenged with reactive oxygen/nitrogen species.

  2005cites this paper
• p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling.

  2004cites this paper
• Justification for antioxidant preconditioning (or how to protect insulin-mediated actions under oxidative stress)

  2003cites this paper
• Insulin and glucagon signaling in regulation of microsomal epoxide hydrolase expression in primary cultured rat hepatocytes.

  2003cites this paper
• Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.

  2003cites this paper
• Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle.

  2002cites this paper
• Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca(2+) entry.

  2002cites this paper
• Inhibition of Insulin Receptor Catalytic Activity by the Molecular Adapter Grb14*

  2002cites this paper
• Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site*

  2002cites this paper
• Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.

  2002cites this paper
• Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells.

  2002cites this paper
• Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms.

  2002cites this paper
• Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes.

  2002cites this paper
• Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐κB and downregulation of AP‐1 activities

  2001cites this paper
• Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts

  2001cites this paper
• Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes.

  2001cites this paper
• GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase.

  2001cites this paper
• The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

  2001cites this paper
• Diabetes, Hypertension, and Cardiovascular Disease: An Update

  2001cites this paper
• An investigation of the potential role of PKC isoforms in the regulation of acetyl-CoA carboxylase-1

  2001cites this paper
• Differential Effects of Phosphatidylinositol 3-Kinase Inhibition on Intracellular Signals Regulating GLUT4 Translocation and Glucose Transport*

  2001cites this paper
• Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by α-lipoic acid in 3T3-L1 adipocytes

  2000cites this paper
• Stimulation of 90- and 70-kDa ribosomal protein S6 kinases by arginine vasopressin and lysophosphatidic acid in rat cardiomyocytes.

  2000cites this paper
• Glucosamine-induced insulin resistance in 3T3-L1 adipocytes.

  2000cites this paper
• GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity.

  1999cites this paper
• Glucosamine-induced insulin resistance in 3 T 3L 1 adipocytes

  1999cites this paper
• Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1*

  1999cites this paper
• An Inhibitor of p38 Mitogen-activated Protein Kinase Prevents Insulin-stimulated Glucose Transport but Not Glucose Transporter Translocation in 3T3-L1 Adipocytes and L6 Myotubes*

  1999cites this paper
• rapid communication GLUT4 myc ectopic expression in L 6 myoblasts generates a GLUT4-specific pool conferring insulin sensitivity

  1999cites this paper
• Identification of Glucagon-like Peptide-2 (GLP-2)-activated Signaling Pathways in Baby Hamster Kidney Fibroblasts Expressing the Rat GLP-2 Receptor*

  1999cites this paper
• The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner.

  1998cites this paper
• GLUT 4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells : potential activation of GLUT 4 via p 38 mitogen-activated protein kinase

  year unknowncites this paper