Deficiency of the lysosomal exonuclease PLD3 impacts the degradative route

Phospholipase D3 (PLD3) is a 5'‐3' exonuclease that resides in lysosomes where it is implicated in the regulation of inflammatory responses by degrading ssDNA. Polymorphisms in the PLD3 gene have been linked to late‐onset Alzheimer’s disease (LOAD; Cruchaga et al., PMID: 24336208), but contradictory data exist on the impact of PLD3 deficiency on APP processing. Given PLD3 is primarily expressed in neurons within the brain, we were interested in exploring its role in neuronal endolysosomal homeostasis.

• Publication year

  2021

• Venue

  Alzheimer's & Dementia

• Publication date

  2021-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/alz.050868PMID 35108818
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

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