SCIENCE@home

Circadian disruption and cisplatin chronotherapy for mammary carcinoma.

Bala S. C. Koritala,K. Porter,Soumyadeep Sarkar,S. Gaddameedhi

Published 2022 in Toxicology and Applied Pharmacology

ABSTRACT

Solid tumors are commonly treated with cisplatin, which can cause off-target side effects in cancer patients. Chronotherapy is a potential strategy to reduce drug toxicity. To determine the effectiveness of timed-cisplatin treatment in mice, we compared two conditions: clock disrupted jet-lag and control conditions. Under normal and disrupted clock conditions, triple-negative breast cancer cells were injected subcutaneously into eight-week-old NOD.Cg-Prkdcscid/J female mice. Tumor volumes and body weights were measured in these animals before and after treatment with cisplatin. We observed an increase in tumor volumes in animals housed under broken clock compared to the normal clock conditions. After treatment with cisplatin, we observed a reduced tumor growth rate in animals treated at ZT10 compared to ZT22 and untreated cohorts of normal clock conditions. However, these changes were not seen with the jet-lag protocol. We also observed greater body weight loss in animals treated with ZT10 compared to ZT22 or untreated animals in the jet-lag protocol. Our observations suggest that the effectiveness of cisplatin in mammary carcinoma treatment is time-dependent in the presence of the circadian clock.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-39 of 39 references · Page 1 of 1

CITED BY

Showing 1-12 of 12 citing papers · Page 1 of 1