ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Immunology

• Publication date

  2016-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1601038PMID 27549171
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hormonal Carcinogenesis

  2020cited by this paper
• ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity

  2016cited by this paper
• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

  2015cited by this paper
• Estradiol Inhibits Th17 Cell Differentiation through Inhibition of RORγT Transcription by Recruiting the ERα/REA Complex to Estrogen Response Elements of the RORγT Promoter

  2015cited by this paper
• DHEA - a precursor of ERβ ligands.

  2015cited by this paper
• The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

  2015cited by this paper
• Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis

  2014cited by this paper
• Osteopontin expression by CD103− dendritic cells drives intestinal inflammation

  2014cited by this paper
• Main features of human T helper 17 cells

  2013influential reference
• From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

  2012cited by this paper
• An ADIOL-ER b-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

  2011cited by this paper
• Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.

  2011cited by this paper
• Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

  2011cited by this paper
• Impaired neurosteroid synthesis in multiple sclerosis.

  2011cited by this paper
• The regulation of IL-10 production by immune cells

  2010cited by this paper
• Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling

  2010cited by this paper
• T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

  2010influential reference
• Regulation of human Th9 differentiation by type I interferons and IL‐21

  2010cited by this paper
• Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi.

  2010cited by this paper
• Estrogen treatment in multiple sclerosis.

  2009cited by this paper
• Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERα)

  2009cited by this paper
• The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

  2009cited by this paper
• Autoimmune T cell responses in the central nervous system

  2009influential reference
• A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.

  2009cited by this paper
• C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

  2009cited by this paper
• Tracing Functional Antigen-Specific CCR6+ Th17 Cells after Vaccination

  2008cited by this paper
• Neurosteroids as modulators of neurogenesis and neuronal survival.

  2008cited by this paper
• Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

  2008cited by this paper
• Protective and therapeutic role for αB-crystallin in autoimmune demyelination

  2007cited by this paper
• Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

  2007cited by this paper
• Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

  2007cited by this paper
• Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.

  2007cited by this paper
• Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

  2007cited by this paper
• Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

  2007cited by this paper
• TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

  2007cited by this paper
• Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

  2006cited by this paper
• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  2006influential reference
• Unopposed estrogen therapy and the risk of invasive breast cancer.

  2006cited by this paper
• Estrogen receptors and human disease.

  2006cited by this paper
• Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.

  2006cited by this paper
• Protection by dehydroepiandrosterone in mice infected with viral encephalitis

  2005cited by this paper
• Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

  2003cited by this paper
• Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

  2003cited by this paper
• Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis

  2001cited by this paper
• Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

  2001influential reference
• Hormonal carcinogenesis.

  2000cited by this paper
• Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity.

  1999cited by this paper
• Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection

  1999cited by this paper
• Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

  1993cited by this paper
• IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

  1992cited by this paper
• Rating neurologic impairment in multiple sclerosis

  1983cited by this paper
• Opus: University of Bath Online Publication Store Steroid Sulfatase: a Pivotal Player in Estrogen Synthesis and Metabolism

  year unknowncited by this paper
• Journal of Steroid Biochemistry and Molecular Biology the Structural Biology of Oestrogen Metabolism

  year unknowncited by this paper

• The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives.

  2025cites this paper
• Neurosteroids, Microbiota, and Neuroinflammation: Mechanistic Insights and Therapeutic Perspectives

  2025cites this paper
• Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

  2025cites this paper
• An Emerging Prospective of Antipsychotics for Treating Neurodegenerative Disorders.

  2025cites this paper
• Neurosteroids and Translocator Protein (TSPO) in neuroinflammation.

  2024cites this paper
• Corticosteroids and the Pharmacological Management of Autism—An Integrative Review

  2024cites this paper
• Neurosteroids: A potential target for neuropsychiatric disorders.

  2024cites this paper
• Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials

  2023cites this paper
• Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance

  2023cites this paper
• ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

  2022cites this paper
• The Similarities and Differences between the Effects of Testosterone and DHEA on the Innate and Adaptive Immune Response

  2022cites this paper
• Advances in the cellular immunological pathogenesis and related treatment of primary ovarian insufficiency

  2022cites this paper
• Targeting Th17 cells in HIV-1 remission/cure interventions.

  2022cites this paper
• Steroid Sulfation in Neurodegenerative Diseases

  2022cites this paper
• Estrogenic Bias in T-Lymphocyte Biology: Implications for Cardiovascular Disease.

  2021cites this paper
• Estriol in regulation of cell-mediated immune reactions in multiple sclerosis.

  2020cites this paper
• Multiomic immune clockworks of pregnancy

  2020cites this paper
• DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

  2020cites this paper
• Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

  2019cites this paper
• The Roles of Sex Hormones in the Course of Atopic Dermatitis

  2019cites this paper
• Neurosteroids as regulators of neuroinflammation.

  2019cites this paper
• Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination

  2019cites this paper
• The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR.

  2019cites this paper
• ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

  2019cites this paper
• Immunoregulatory Functions of Nuclear Receptors: Mechanisms and Therapeutic Implications.

  2019cites this paper
• Estrogen serum concentration affects blood immune cell composition and polarization in human females under controlled ovarian stimulation.

  2018cites this paper
• The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA

  2017cites this paper
• Vitamin D : Autoimmunity and Gender.

  2017cites this paper
• Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation

  2017cites this paper
• Autoimmunity in 2016

  2017cites this paper