RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High-resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.

• Publication year

  2022

• Venue

  Journal of Microbiology and Biotechnology

• Publication date

  2022-01-16

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.4014/jmb.2110.10039PMID 35058400PMCID 9628841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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