Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Annals of the Rheumatic Diseases

• Publication date

  2004-01-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/ard.2003.006494PMID 14722200PMCID PMC1754886
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Increased expression of multidrug resistance of P-glycoprotein on Th1 cells correlates with drug resistance in rheumatoid arthritis.

  1999cited by this paper
• Combination therapy in rheumatoid arthritis.

  1999cited by this paper
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  1999cited by this paper
• Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.

  1999cited by this paper
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  1999cited by this paper
• Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

  1998cited by this paper
• A multidrug resistance transporter from human MCF-7 breast cancer cells.

  1998cited by this paper
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• Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.

  1998cited by this paper
• Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

  1998cited by this paper
• Proteasome inhibitors: valuable new tools for cell biologists.

  1998cited by this paper
• Adverse drug reactions of DMARDs and DC-ARTs in rheumatoid arthritis.

  1997cited by this paper
• Effect of resumption of second line drugs in patients with rheumatoid arthritis that flared up after treatment discontinuation

  1997cited by this paper
• Expression of the multidrug resistance‐associated protein (MRP) mRNA and protein in normal peripheral blood and bone marrow haemopoietic cells

  1996cited by this paper
• Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone.

  1996cited by this paper
• Relevance of multidrug resistance to rheumatoid arthritis: development of a new therapeutic hypothesis.

  1996cited by this paper
• Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis.

  1995cited by this paper
• The epidemiology of drug treatment failure in rheumatoid arthritis.

  1995cited by this paper
• Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line.

  1991cited by this paper
• Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

  1986cited by this paper
• Inhibition by sulfasalazine of LTC synthetase and of rat liver glutathione S-transferases.

  1985cited by this paper
• Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.

  1985cited by this paper
• The disposition and metabolism of sulphasalazine (salicylazosulphapyridine) in man.

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  1981cited by this paper
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  1976cited by this paper

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