Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemistry

• Publication date

  2003-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI027383TPMID 12653542
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Two-drug Model for Etoposide Action against Human Topoisomerase IIα*

  2003cited by this paper
• DNA Topoisomerase II as a Target for Cancer Chemotherapy

  2002cited by this paper
• Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.

  2002cited by this paper
• Cellular roles of DNA topoisomerases: a molecular perspective

  2002cited by this paper
• Tumor cell death induced by topoisomerase-targeting drugs.

  2001cited by this paper
• DNA cleavage and religation by human topoisomerase II alpha at high temperature.

  2001cited by this paper
• DNA topoisomerases: structure, function, and mechanism.

  2001cited by this paper
• Positioning the 3′-DNA Terminus for Topoisomerase II-mediated Religation*

  2001cited by this paper
• Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement.

  2000cited by this paper
• Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.

  2000cited by this paper
• Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions.

  2000cited by this paper
• Molecular Analysis of Yeast and Human Type II Topoisomerases

  1999cited by this paper
• Differential in vitro interactions of a series of clinically useful topoisomerase-interacting compounds with the cleavage/religation activity of the human topoisomerase IIalpha and IIbeta isoforms.

  1999cited by this paper
• DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement.

  1999cited by this paper
• Quinolones Inhibit DNA Religation Mediated by Staphylococcus aureus Topoisomerase IV

  1999cited by this paper
• Structural Insight into a Quinolone-Topoisomerase II-DNA Complex

  1999cited by this paper
• Investigating the biological functions of DNA topoisomerases in eukaryotic cells.

  1998cited by this paper
• The response of eukaryotic topoisomerases to DNA damage.

  1998cited by this paper
• Secondary leukemias induced by topoisomerase-targeted drugs.

  1998cited by this paper
• Topoisomerase II Site-directed Alkylation of DNA by Psorospermin and Its Effect on Topoisomerase II-mediated DNA Cleavage*

  1998cited by this paper
• Topoisomerase II-mediated DNA Cleavage and Religation in the Absence of Base Pairing

  1998cited by this paper
• Cell death induced by topoisomerase-targeted drugs: more questions than answers.

  1998cited by this paper
• Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

  1998cited by this paper
• Structure of DNA topoisomerases.

  1998cited by this paper
• Catalytic inhibitors of DNA topoisomerase II.

  1998cited by this paper
• Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme.

  1998cited by this paper
• Mutagenic properties of topoisomerase-targeted drugs.

  1998cited by this paper
• The critical role of chromosome translocations in human leukemias.

  1998cited by this paper
• Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage*

  1997cited by this paper
• Mechanism of Quinolone Action

  1997cited by this paper
• Apurinic Sites Are Position-specific Topoisomerase II Poisons*

  1997cited by this paper
• Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints.

  1997cited by this paper
• DNA topoisomerases.

  1996cited by this paper
• Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements.

  1995cited by this paper
• Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.

  1995cited by this paper
• Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II

  1995cited by this paper
• Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.

  1994cited by this paper
• Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.

  1993cited by this paper
• A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavage.

  1992cited by this paper
• Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

  1992cited by this paper
• Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

  1991cited by this paper
• Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

  1990cited by this paper
• Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.

  1989cited by this paper
• Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

  1989cited by this paper
• Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA.

  1989cited by this paper
• Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model.

  1989cited by this paper
• Cleavage of DNA by mammalian DNA topoisomerase II.

  1983cited by this paper
• Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.

  1983cited by this paper
• Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth

  1979cited by this paper

• Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq.

  2024cites this paper
• Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq

  2024cites this paper
• Anticancer activity and metabolic alteration in colon and prostate cancer cells by novel moxifloxacin conjugates with fatty acids.

  2022cites this paper
• A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo

  2022cites this paper
• Enoxacin Up‐Regulates MicroRNA Biogenesis and Down‐Regulates Cytotoxic CD8 T‐Cell Function in Autoimmune Cholangitis

  2021cites this paper
• Quantum chemical calculations on sparfloxacin and boron complexes

  2019cites this paper
• Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.

  2018cites this paper
• Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice

  2018cites this paper
• Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism

  2017cites this paper
• Molecular docking studies on thirteen fluoroquinolines with human topoisomerase II a and b

  2017cites this paper
• Rh(III) and Ru(II)-catalyzed site-selective C-H alkynylation of quinolones.

  2015cites this paper
• Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.

  2015cites this paper
• In vitro moxifloxacin drug interaction with chemotherapeutics: implications for retinoblastoma management.

  2014cites this paper
• A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues.

  2014cites this paper
• Methoxyphenylcipro induces antitumor activity in human cancer cells

  2013cites this paper
• Methoxyphenylcipro induces antitumor activity in human cancer cells Nizar M. MhaidatAmjad M. QandilQosay A. Al-Balas • Mohammad A. HassanSaied A. JaradatAhmad M. Matalkah •

  2013cites this paper
• Synthesis, characterization, DNA binding and cytotoxicity studies of moxifloxacinato complexes

  2012cites this paper
• Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage–religation equilibrium

  2012cites this paper
• Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

  2011cites this paper
• Spectroscopic investigation on protein damage by ciprofloxacin under ultrasonic irradiation.

  2011cites this paper
• Synthesis, characterization and anti-tumor activity of moxifloxacin-copper complexes against breast cancer cell lines.

  2011cites this paper
• Fragments of microcin B17 as a source of new topoisomerase inhibitors

  2010cites this paper
• Direct C‐3‐Alkenylation of Quinolones via Palladium‐Catalyzed CH Functionalization

  2010cites this paper
• Moxifloxacin increases anti-tumor and anti-angiogenic activity of irinotecan in human xenograft tumors.

  2010cites this paper
• Moxifloxacin enhances etoposide-induced cytotoxic, apoptotic and anti-topoisomerase II effects in a human colon carcinoma cell line.

  2010cites this paper
• DNA topoisomerases I from Pseudomonas aeruginosa and vaccinia virus and their use as drug targets

  2009cites this paper
• Quinolones as enhancers of camptothecin-induced cytotoxic and anti-topoisomerase I effects.

  2008cites this paper
• The role of ErbB2 and BRCA1 in repair of drug-induced DNA damage.

  2007cites this paper
• DNA topoisomerase II, genotoxicity, and cancer.

  2007cites this paper
• Does topoisomerase II specifically recognize and cleave hairpins, cruciforms and crossovers of DNA?

  2007cites this paper
• Heterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, part IV. Convenient synthesis of substituted hexahydro [1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog.

  2007cites this paper
• Interdomain Communication in DNA Topoisomerase II

  2006cites this paper
• Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones

  2006cites this paper
• Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells

  2006influential citation
• Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

  2006cites this paper
• The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.

  2006cites this paper
• Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant

  2005cites this paper
• Genetic interaction between DNA polymerase β and DNA-PKcs in embryogenesis and neurogenesis

  2005cites this paper
• Uncoupling the Chemical Steps of Telomere Resolution by ResT*

  2005cites this paper
• Novel Symmetric and Asymmetric DNA Scission Determinants for Streptococcus pneumoniae Topoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site*

  2005cites this paper
• Molecular basis of gyrase poisoning by the addiction toxin CcdB.

  2005cites this paper
• Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

  2005cites this paper
• Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison.

  2005cites this paper
• The molecular basis of leukemia.

  2004cites this paper
• Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

  2004cites this paper
• 1,4-Benzoquinone is a topoisomerase II poison.

  2004cites this paper
• DNA ligation catalyzed by human topoisomerase II alpha.

  2004cites this paper
• Fluoroquinolone-dependent DNA supercoiling by Vaccinia topoisomerase I.

  2004cites this paper
• The Action of the Bacterial Toxin Microcin B17

  2003cites this paper