Patients' experiences and opinions after de-simplification of their single-tablet regimens for the treatment of HIV infection: a survey in a multicentre cohort.

OBJECTIVES The aims of this study were to describe patients' experiences after single-tablet regimen (STR) de-simplification, and its impact on self-reported treatment adherence and quality of life. METHODS We performed a survey among all patients from the multicenter cohort of the Spanish HIV/AIDS Network (CoRIS) who had de-simplified the STRs dolutegravir/abacavir/lamivudine (DGT/ABC/3TC) or rilpivirine/tenofovir disoproxil fumarate/emtricitabine (RPV/TDF/FTC) to their separate components (DTG+generic ABC/3TC or RPV+generic TDF/FTC, respectively) between December 2016 and November 2018. RESULTS Among 216 patients who fulfilled inclusion criteria, 138 (63.9%) completed the questionnaire. The majority (78.3%) knew what generic drugs are, only 8.7% thought that treatment with two pills is less effective than treatment with an STR, and 67.4% agreed that it is reasonable to take two pills instead of one for HIV treatment in order to decrease costs for the healthcare system.After de-simplification, 13.0% of the patients stated they had more secondary effects, 8.0% had forgotten one or more doses more frequently than before, and 10.9% had sometimes forgotten to take one pill, but not the other. A proportion of 30.4% reported not being happy to take more pills a day and 10.1% experienced a worse quality of life after the treatment de-simplification. CONCLUSIONS After STR de-simplification, most patients had a fair knowledge about generic antiretrovirals , and they agreed to de-simplify their STR in order to decrease costs. Although almost a third of the respondents were not happy to take two pills a day, only a minority reported worse adherence or quality of life.

• Publication year

  2022

• Venue

  Journal of Acquired Immune Deficiency Syndromes

• Publication date

  2022-01-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/QAI.0000000000002923PMID 35090156
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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