TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Apoptosis

• Publication date

  2014-11-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10495-014-1063-3PMID 25413799
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))*

  2014cited by this paper
• Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43.

  2014cited by this paper
• Drug‐Target Residence Time—A Case for G Protein‐Coupled Receptors

  2014cited by this paper
• Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor

  2013cited by this paper
• Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

  2013cited by this paper
• Extracts from Epilobium sp. herbs induce apoptosis in human hormone‐dependent prostate cancer cells by activating the mitochondrial pathway

  2013cited by this paper
• A TSPO ligand is protective in a mouse model of multiple sclerosis

  2013cited by this paper
• Dimers of mitochondrial ATP synthase form the permeability transition pore

  2013cited by this paper
• Role of mitochondrial translocator protein (18 kDa) on mitochondrial- related cell death processes.

  2013cited by this paper
• Translocator Protein (18 kDa): A Promising Therapeutic Target and Diagnostic Tool for Cardiovascular Diseases

  2012cited by this paper
• PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells.

  2012cited by this paper
• Axonal Regeneration and Neuroinflammation: Roles for the Translocator Protein 18 kDa

  2012cited by this paper
• Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)?

  2012cited by this paper
• Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.

  2012cited by this paper
• Translocator protein as a promising target for novel anxiolytics.

  2012cited by this paper
• Unique Responses of Stem Cell-Derived Vascular Endothelial and Mesenchymal Cells to High Levels of Glucose

  2012cited by this paper
• Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.

  2011cited by this paper
• Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.

  2010cited by this paper
• Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

  2010cited by this paper
• Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

  2010cited by this paper
• Translocator protein ligands as promising therapeutic tools for anxiety disorders.

  2009cited by this paper
• Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma.

  2009cited by this paper
• PK 11195 differentially affects cell survival in human wild‐type and 18 kDa translocator protein‐silenced ADF astrocytoma cells

  2008cited by this paper
• The 18-kDa translocator protein, formerly known as the peripheral-type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line

  2008cited by this paper
• Residence time of receptor-ligand complexes and its effect on biological function.

  2008cited by this paper
• Drug–target residence time and its implications for lead optimization

  2007cited by this paper
• Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition.

  2007cited by this paper
• Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor.

  2007cited by this paper
• Methods for the assessment of mitochondrial membrane permeabilization in apoptosis

  2007cited by this paper
• The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria.

  2007cited by this paper
• Peripheral Benzodiazepine Receptor-Induced Myocardial Protection is Mediated by Inhibition of Mitochondrial Membrane Permeabilization

  2007cited by this paper
• Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

  2006cited by this paper
• Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist.

  2005cited by this paper
• Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion

  2005cited by this paper
• Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.

  2005cited by this paper
• PIGA (N,N‐Di‐n‐butyl‐5‐chloro‐2‐(4‐chlorophenyl)indol‐3‐ylglyoxylamide), a New Mitochondrial Benzodiazepine‐Receptor Ligand, Induces Apoptosis in C6 glioma Cells

  2005cited by this paper
• Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis

  2005cited by this paper
• Peripheral-type benzodiazepine receptor density and in vitro tumorigenicity of glioma cell lines.

  2004cited by this paper
• Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.

  2004cited by this paper
• Comparison of Established Cell Lines at Different Passages by Karyotype and Comparative Genomic Hybridization

  2004cited by this paper
• Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.

  2004cited by this paper
• The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.

  2004cited by this paper
• Peripheral type benzodiazepine receptor in human parathyroid glands: Up-regulation in adenoma

  2004cited by this paper
• N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

  2004cited by this paper
• Phase II Study of Lonidamine and Diazepam in the Treatment of Recurrent Glioblastoma Multiforme

  2003cited by this paper
• Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway

  2003cited by this paper
• In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding.

  2003cited by this paper
• Role of Peripheral Benzodiazepine Receptors in Mitochondrial, Cellular, and Cardiac Damage Induced by Oxidative Stress and Ischemia-Reperfusion

  2003cited by this paper
• Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-XL and Mcl-1 expressing human cholangiocarcinoma cells

  2002cited by this paper
• Modulation of tamoxifen-induced apoptosis by peripheral benzodiazepine receptor ligands in breast cancer cells.

  2002cited by this paper
• Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR.

  2002cited by this paper
• PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism.

  2002cited by this paper
• Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.

  2002cited by this paper
• Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.

  2002cited by this paper
• Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: role of mitochondrial permeability transition and metabolic activation.

  2001cited by this paper
• Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells

  2001cited by this paper
• Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.

  2001cited by this paper
• Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

  2001cited by this paper
• Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.

  2000cited by this paper
• Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities.

  1999cited by this paper
• Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol.

  1999cited by this paper
• Mitochondrial transport of cations: channels, exchangers, and permeability transition.

  1999cited by this paper
• Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: absence of correlation with binding to the peripheral-type benzodiazepine binding site.

  1998cited by this paper
• PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

  1998cited by this paper
• Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure.

  1998cited by this paper
• Effect of passage number on cellular response to DNA-damaging agents: cell survival and gene expression.

  1997cited by this paper
• Photoaffinity labeling of peripheral benzodiazepine receptors in R-3327 Dunning prostatic tumors.

  1996cited by this paper
• Acute action of choriogonadotropin on Leydig tumor cells: changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor.

  1996cited by this paper
• Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition.

  1995cited by this paper
• Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

  1994cited by this paper
• Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

  1993cited by this paper
• A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

  1993cited by this paper
• Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

  1992cited by this paper
• Characterization of peripheral-type benzodiazepine binding sites on human lymphocytes and lymphoma cell lines and their role in cell growth.

  1992cited by this paper
• Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

  1991cited by this paper
• Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.

  1990cited by this paper
• Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.

  1990cited by this paper
• Antiproliferative Action of Benzodiazepines in Cultured Brain Cells Is Not Mediated Through the Peripheral‐Type Benzodiazepine Acceptor

  1989cited by this paper
• [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland

  1989cited by this paper
• Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one.

  1987cited by this paper
• AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors.

  1986cited by this paper
• Comparison of liver tumor frequencies after intermittent oral administration of different doses of N-nitrosopyrrolidine in Sprague-Dawley rats.

  1985cited by this paper

• Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity.

  2024cites this paper
• The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.

  2023cites this paper
• Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents

  2023cites this paper
• Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury.

  2022cites this paper
• Translocator Protein 18-kDa: a promising target to treat neuroinflammation-related degenerative diseases.

  2022cites this paper
• Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand.

  2021cites this paper
• 18-kDa TranSlocator protein association complexes in the brain: from structure to function.

  2020cites this paper
• Evaluation of [18F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

  2020cites this paper
• An update into the medicinal chemistry of translocator protein (TSPO) ligands.

  2020cites this paper
• The Role of Translocator Protein TSPO in Hallmarks of Glioblastoma

  2020cites this paper
• The first non-discriminating TSPO ligands produced from a carbazole scaffold.

  2019cites this paper
• Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry

  2018cites this paper
• 4′-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation

  2017cites this paper
• Role of Translocator 18 KDa Ligands in the Activation of Leukotriene B4 Activated G-Protein Coupled Receptor and Toll Like Receptor-4 Pathways in Neutrophils

  2017cites this paper
• The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage

  2017cites this paper
• Derivatives of the pyrazolo[1,5‐a]pyrimidine acetamide DPA‐713 as translocator protein (TSPO) ligands and pro‐apoptotic agents in human glioblastoma

  2017cites this paper
• Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling

  2017influential citation
• Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination

  2016cites this paper
• Long lasting MDM 2 / Translocator protein modulator : a new strategy for irreversible apoptosis of human glioblastoma cells

  2016cites this paper
• Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.

  2016cites this paper
• Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

  2016cites this paper
• TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?

  2016cites this paper
• TSPO as a target for glioblastoma therapeutics.

  2015cites this paper
• The changing landscape in translocator protein (TSPO) function.

  2015cites this paper