One Bout of Resistance Training Does Not Enhance Metformin Actions in Prediabetic and Diabetic Individuals

ABSTRACT Purpose This study aimed to determine the separated and combined effects of metformin and resistance exercise on glycemic control, insulin sensitivity, and insulin-like growth factor 1 (IGF-1) in overweight/obese individuals with prediabetes and type 2 diabetes mellitus. Methods Fourteen adults with a body mass index of 32.1 ± 4.1 kg·m−2, insulin resistance (HOMA-2 1.6 ± 0.6), and poor glycemic control (glycated hemoglobin, 6.9% ± 0.9%; 51.9 ± 10.7 mmol·mol−1) while taking metformin (1561 ± 470 g·d−1) were recruited. Participants underwent four 72-h long experimental trials in a randomized counterbalanced order, either 1) taking metformin (MET), 2) replacing metformin by placebo pills (PLAC), 3) taking placebo and undergoing a resistance training bout (RT + PLAC), and 4) taking metformin and undergoing the same RT bout (RT + MET). Interstitial fluid glucose concentration was frequently sampled to obtain 72-h glucose area under the curve (GAUC) and the percentage hyperglycemic glucose readings (>180 mg·dL−1; GPEAKS). Insulin sensitivity (i.e., HOMA-2) and IGF-1 were also assessed. Results HOMA-2 was not affected by treatments. GAUC and GPEAKS were similarly reduced below PLAC during RT + MET and MET (all P < 0.05). In contrast, RT + PLAC did not affect glucose concentration. Metformin decreased serum IGF-1 concentrations (P = 0.006), and RT did not reverse this reduction. Conclusions A bout of full-body RT does not interfere or aid on metformin’s blood glucose–lowering actions in individuals with prediabetes and type 2 diabetes mellitus.

• Publication year

  2022

• Venue

  Medicine & Science in Sports & Exercise

• Publication date

  2022-02-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1249/MSS.0000000000002889PMID 35142713
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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