Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns

No abstract is available for this paper.

• Publication year

  2016

• Venue

  RNA Biology

• Publication date

  2016-05-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/15476286.2016.1191727PMID 27245359PMCID PMC4962795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Whereabouts of microRNA Actions: Cytoplasm and Beyond.

  2015cited by this paper
• Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs

  2015cited by this paper
• Fip1 regulates mRNA alternative polyadenylation to promote stem cell self‐renewal

  2014cited by this paper
• Context-dependent control of alternative splicing by RNA-binding proteins

  2014cited by this paper
• Counting on co-transcriptional splicing

  2013cited by this paper
• TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

  2013cited by this paper
• Splicing-coupled 3′ end formation requires a terminal splice acceptor site, but not intron excision

  2013cited by this paper
• Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3′ processing

  2013cited by this paper
• Transcriptome-wide analyses of CstF64–RNA interactions in global regulation of mRNA alternative polyadenylation

  2012cited by this paper
• Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins.

  2012cited by this paper
• Functional microRNA targets in protein coding sequences

  2012cited by this paper
• A quantitative atlas of polyadenylation in five mammals

  2012cited by this paper
• Translational control by 3′-UTR-binding proteins

  2012cited by this paper
• Mechanisms and consequences of alternative polyadenylation.

  2011cited by this paper
• Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq.

  2011cited by this paper
• RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing

  2011cited by this paper
• The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

  2011cited by this paper
• Analysis and design of RNA sequencing experiments for identifying isoform regulation

  2010influential reference
• First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal.

  2010cited by this paper
• U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

  2010cited by this paper
• Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

  2010influential reference
• Molecular architecture of the human pre-mRNA 3' processing complex.

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells.

  2009cited by this paper
• Co-transcriptional splicing of constitutive and alternative exons.

  2009cited by this paper
• Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation

  2009cited by this paper
• Pre-mRNA processing reaches back to transcription and ahead to translation.

  2009cited by this paper
• Alternative Promoters Influence Alternative Splicing at the Genomic Level

  2008cited by this paper
• Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

  2008cited by this paper
• Alternative Isoform Regulation in Human Tissue Transcriptomes

  2008cited by this paper
• Functional Coupling of Last-Intron Splicing and 3′-End Processing to Transcription In Vitro: the Poly(A) Signal Couples to Splicing before Committing to Cleavage

  2007cited by this paper
• Chromatin, transcript elongation and alternative splicing

  2006cited by this paper
• Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing.

  2006cited by this paper
• Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

  2006cited by this paper
• Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3′-UTRs

  2006influential reference
• Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells

  2006cited by this paper
• An interaction between U2AF 65 and CF Im links the splicing and 3′ end processing machineries

  2006cited by this paper
• A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants

  2006cited by this paper
• Heterogeneous Nuclear Ribonucleoprotein-A2/B1 Modulate Collagen Prolyl 4-Hydroxylase, α (I) mRNA Stability*

  2006cited by this paper
• 3′ End cDNA amplification using classic RACE

  2006cited by this paper
• Conservation of alternative polyadenylation patterns in mammalian genes

  2006cited by this paper
• 5′ end cDNA amplification using classic RACE

  2006cited by this paper
• Splice variants as cancer biomarkers.

  2004cited by this paper
• Complex controls: the role of alternative promoters in mammalian genomes.

  2003cited by this paper
• A slow RNA polymerase II affects alternative splicing in vivo.

  2003cited by this paper
• Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences.

  2003cited by this paper
• Computational analysis and experimental validation of tumor-associated alternative RNA splicing in human cancer.

  2003cited by this paper
• Pre-mRNA splicing and human disease.

  2003cited by this paper
• A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.

  2003cited by this paper
• The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression

  2003cited by this paper
• Listening to silence and understanding nonsense: exonic mutations that affect splicing

  2002cited by this paper
• Promoter Choice Influences Alternative Splicing and Determines the Balance of Isoforms Expressed from the Mousebcl-X Gene*

  2001cited by this paper
• The 3′ untranslated region of messenger RNA: A molecular ‘hotspot’ for pathology?

  2000cited by this paper
• The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing.

  2000cited by this paper
• RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.

  1999cited by this paper
• Utilization of Splicing Elements and Polyadenylation Signal Elements in the Coupling of Polyadenylation and Last-Intron Removal

  1999cited by this paper
• U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase.

  1998cited by this paper
• Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

  1997cited by this paper
• Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

  1996cited by this paper
• The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation.

  1996cited by this paper
• Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA

  1993cited by this paper
• Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

  1991cited by this paper
• In vitro polyadenylation is stimulated by the presence of an upstream intron.

  1990cited by this paper

• MALAT1 regulates mRNA processing through sequence dependent RNA–RNA and RNA–protein interactions

  2025cites this paper
• Transcription termination promotes splicing efficiency and fidelity in a compact genome

  2025cites this paper
• Transcription termination promotes splicing efficiency and fidelity in a compact genome

  2025cites this paper
• NUDT21 Regulates Macrophage Cytokine Responses via Alternative Polyadenylation in ARDS

  2025cites this paper
• Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR

  2024cites this paper
• Coupling of alternative splicing and alternative polyadenylation

  2024cites this paper
• Generation of Transcript Length Variants and Reprogramming of mRNA Splicing During Atherosclerosis Progression in ApoE-Deficient Mice

  2024cites this paper
• ASAPA: a bioinformatic pipeline based on Iso-Seq that identifies the links among alternative splicing, alternative transcription initiation and alternative polyadenylation

  2024cites this paper
• A modular platform for bioluminescent RNA tracking

  2023cites this paper
• pA regulator: a system for controlling mammalian gene expression via the modulation of polyA signal cleavage

  2023cites this paper
• Alternative polyadenylation regulation in cardiac development and cardiovascular disease.

  2023cites this paper
• A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristics

  2022cites this paper
• Alternative splicing and alternative polyadenylation define tumor immune microenvironment and pharmacogenomic landscape in clear cell renal carcinoma

  2022cites this paper
• PiggyBac Transposable Element-derived 1 controls Neuronal Progenitor Identity, Stress Sensing and mammal-specific paraspeckles

  2021cites this paper
• Comprehensive discovery of salt-responsive alternative splicing events based on Iso-Seq and RNA-seq in grapevine roots

  2021cites this paper
• Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation

  2021cites this paper
• PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

  2021cites this paper
• Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation.

  2021cites this paper
• Mutations in cis that affect mRNA synthesis, processing and translation.

  2021cites this paper
• The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation

  2020cites this paper
• Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds

  2020cites this paper
• Conserved long-range base pairings are associated with pre-mRNA processing of human genes

  2020cites this paper
• Systems Virology and Human Cytomegalovirus: Using High Throughput Approaches to Identify Novel Host-Virus Interactions During Lytic Infection

  2020cites this paper
• Alternative Polyadenylation: a new frontier in post transcriptional regulation

  2020cites this paper
• Genome-Wide Profiling of Polyadenylation Events in Maize Using High-Throughput Transcriptomic Sequences

  2019cites this paper
• Comprehensive characterization of transcript diversity at the human NODAL locus

  2018cites this paper
• CFIm25 inhibits hepatocellular carcinoma metastasis by suppressing the p38 and JNK/c-Jun signaling pathways

  2018cites this paper
• Coordinated Regulation of Alternative Splicing and AlternativePolyadenylation

  2018cites this paper
• Long-read sequencing of nascent RNA reveals coupling among RNA processing events

  2018cites this paper
• RNA-binding proteins control gene expression and cell fate in the immune system

  2018cites this paper
• Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

  2018cites this paper
• QAPA: a new method for the systematic analysis of alternative polyadenylation from RNA-seq data

  2018cites this paper
• Nuclear retention of mRNAs - quality control, gene regulation and human disease.

  2017cites this paper
• Alternative polyadenylation in the regulation and dysregulation of gene expression.

  2017cites this paper
• Full-length mRNA sequencing uncovers a widespread coupling between transcription and mRNA processing

  2017cites this paper
• The determinants of alternative RNA splicing in human cells

  2017cites this paper
• Antisense Oligonucleotides Promote Exon Inclusion and Correct the Common c.-32-13T>G GAA Splicing Variant in Pompe Disease

  2017cites this paper
• Long-read sequencing of nascent RNA in S. pombe reveals coupling among RNA processing events

  2017cites this paper
• Trinucleotide-repeat expanded and normal DMPK transcripts contain unusually long poly(A) tails despite differential nuclear residence.

  2017cites this paper
• Comprehensive Molecular Characterization of Human NODAL

  2016influential citation
• Post-transcriptional gene regulation by mRNA modifications

  2016cites this paper
• Mechanisms controlling mRNA processing and translation: decoding the regulatory layers defining gene expression through RNA sequencing

  2015cites this paper