Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohort

Chronic kidney disease (CKD) has been recognized as a highly prevalent risk factor for both the severity of coronavirus disease 2019 (COVID-19) and COVID-19 associated adverse outcomes. In this multicenter observational cohort study, we aim to determine mortality and readmission rates of patients hospitalized for COVID-19 across varying CKD stages. We performed a multicenter cohort study among COVID-19 patients included in the Dutch COVIDPredict cohort. The cohort consists of hospitalized patients from March 2020 until July 2021 with PCR-confirmed SARS-CoV-2 infection or a highly suspected CT scan-based infection with a CORADS score ≥ 4. A total of 4151 hospitalized COVID-19 patients were included of who 389 had a history of CKD before admission. After adjusting for all confounding covariables, in patients with CKD stage 3a, stage 3b, stage 4 and patients with KTX (kidney transplantation), odds ratios of death and readmission compared to patients without CKD ranged from 1.96 to 8.94. We demonstrate an evident increased 12-week mortality and readmission rate in patients with chronic kidney disease. Besides justified concerns for kidney transplant patients, clinicians should also be aware of more severe COVID-19 outcomes and increased vulnerability in CKD patients.

• Publication year

  2022

• Venue

  Scientific Reports

• Publication date

  2022-02-10

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1038/s41598-022-06276-7PMID 35145189PMCID 8831646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Host genetic factors determining COVID-19 susceptibility and severity

  2021cited by this paper
• The impact of COVID‐19 on kidney transplantation and the kidney transplant recipient – One year into the pandemic

  2021cited by this paper
• Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine

  2021cited by this paper
• Occurrence of severe COVID-19 in vaccinated transplant patients

  2021cited by this paper
• Dexamethasone in Hospitalized Patients with Covid-19

  2021cited by this paper
• Predicting mortality of individual patients with COVID-19: a multicentre Dutch cohort

  2021cited by this paper
• Outcomes of persons with coronavirus disease 2019 in hospitals with and without standard treatment with (hydroxy)chloroquine

  2020cited by this paper
• COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration

  2020cited by this paper
• Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA

  2020cited by this paper
• Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

  2020cited by this paper
• Clinical Characteristics of Coronavirus Disease 2019 in China

  2020cited by this paper
• CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation

  2020cited by this paper
• Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.

  2020cited by this paper
• OpenSAFELY: factors associated with COVID-19 death in 17 million patients

  2020cited by this paper
• CKD is a key risk factor for COVID-19 mortality

  2020cited by this paper
• Functional Composites and Structures

  2019cited by this paper
• Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

  2013cited by this paper

• Vaccines as a Core Conversation in Nephrology.

  2025cites this paper
• Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19

  2025influential citation
• Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients

  2025cites this paper
• COVID-19 Hospitalization and Mortality Trends Among US Dialysis Patients by Race/Ethnicity and Vaccination Status

  2025cites this paper
• Prognosis of patients with a history of organ transplantation during active COVID-19 infection

  2025cites this paper
• Red blood cell distribution width-to-monocyte ratio for predicting 90-day mortality of COVID-19 in patients with chronic kidney disease during the Omicron period: a prospective single-center study

  2024cites this paper
• More severe comorbidities, advanced age, and incomplete vaccination increase the risk of COVID-19 mortality

  2024cites this paper
• Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals

  2024cites this paper
• Mortality Predictors in Patients With COVID-19 Referred to the Emergency Department in Bandar Abbas, Southern Iran: A Single-Center Experience

  2024influential citation
• SARS-CoV-2-specific immune responses converge in kidney disease patients and controls with hybrid immunity

  2024cites this paper
• Serological responses and clinical outcomes following a three‐dose primary COVID‐19 vaccine schedule in kidney transplant recipients and people on dialysis

  2024influential citation
• Risk Factors, Symptomatology, and Predictors of Mortality Among COVID-19 Inpatients Presenting With Delirium Symptoms in a Tertiary Hospital in the Philippines

  2024cites this paper
• Association of renal function with mortality among hospitalized patients treated with remdesivir for COVID-19

  2023cites this paper
• Recognizing risk factors associated with poor outcomes among patients with COVID-19

  2023cites this paper
• The prognostic value of estimated glomerular filtration rate on admission for death within 30 days among COVID-19 inpatients using fractional polynomial and spline smoothing

  2023cites this paper
• COVID-19 in patients with chronic kidney disease: a 2-year study of incidence and mortality in relation to the variants of concern waves in Brazil.

  2023cites this paper
• Higher urea-to-albumin ratio is associated with mortality risk in critically ill COVID-19 patients

  2023cites this paper
• Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19

  2023cites this paper
• Predicting SARS-CoV-2 infection among hemodialysis patients using multimodal data

  2023cites this paper
• Thrombocytopenia is associated with a dysregulated host response in severe COVID-19.

  2023cites this paper
• Adherence to preventive measures after SARS-CoV-2 vaccination and after awareness of antibody response in kidney transplant recipients in the Netherlands: a nationwide questionnaire study

  2023cites this paper
• Outcomes and mortality of chronic haemodialysis patients in community-based dialysis centres in Singapore during the COVID-19 pandemic.

  2023cites this paper
• Risk factors for COVID-19 hospitalization and mortality in patients with chronic kidney disease: a nationwide cohort study

  2023cites this paper
• Predictors of Nonseroconversion to SARS-CoV-2 Vaccination in Kidney Transplant Recipients

  2022cites this paper
• COVID-19 Booster Vaccine Hesitancy among Hemodialysis Patients in Saudi Arabia Using the Health Belief Model: A Multi-Centre Experience

  2022cites this paper
• Preparing European Nephrology for the next pandemic: lessons from the ERACODA collaboration

  2022cites this paper