p75 neurotrophin receptor is required for constitutive and NGF‐induced survival signalling in PC12 cells and rat hippocampal neurones

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neurochemistry

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.2002.00841.xPMID 12065668
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

  2001cited by this paper
• The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway*

  2001cited by this paper
• Activation of Nuclear Factor κb and bcl-x Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of IκBα

  2001cited by this paper
• A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2

  2001cited by this paper
• NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

  2001cited by this paper
• p75 Reduces TrkB Tyrosine Autophosphorylation in Response to Brain-derived Neurotrophic Factor and Neurotrophin 4/5*

  2000cited by this paper
• The Ras/Phosphatidylinositol 3-Kinase and Ras/ERK Pathways Function as Independent Survival Modules Each of Which Inhibits a Distinct Apoptotic Signaling Pathway in Sympathetic Neurons*

  2000cited by this paper
• Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

  2000cited by this paper
• Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

  2000cited by this paper
• The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

  2000cited by this paper
• Apoptosis in the nervous system

  2000cited by this paper
• Nerve Growth Factor Activation of Nuclear Factor κB through Its p75 Receptor Is an Anti-apoptotic Signal in RN22 Schwannoma Cells*

  2000cited by this paper
• Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site*

  2000cited by this paper
• NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells

  2000influential reference
• The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-xL

  2000cited by this paper
• Neurotrophin signal transduction in the nervous system.

  2000cited by this paper
• NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.

  1999cited by this paper
• Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons

  1999cited by this paper
• NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.

  1999cited by this paper
• Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

  1999cited by this paper
• NF-κB is a target of AKT in anti-apoptotic PDGF signalling

  1999cited by this paper
• Nerve Growth Factor Determines Survival and Death of PC12 Cells by Regulation of the bcl‐x, bax, and caspase‐3 Genes

  1999cited by this paper
• Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

  1999influential reference
• Association of the p75 Neurotrophin Receptor with TRAF6*

  1999cited by this paper
• Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.

  1999cited by this paper
• NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

  1999cited by this paper
• p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

  1999cited by this paper
• A Role for MAPK/ERK in Sympathetic Neuron Survival: Protection against a p53-Dependent, JNK-Independent Induction of Apoptosis by Cytosine Arabinoside

  1999cited by this paper
• Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

  1999cited by this paper
• The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons

  1999cited by this paper
• TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction*

  1999cited by this paper
• Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

  1998cited by this paper
• Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

  1998cited by this paper
• p75NTR: A study in contrasts

  1998cited by this paper
• Autocrine regulation of neurite outgrowth from PC12 cells by nerve growth factor.

  1998cited by this paper
• Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

  1998cited by this paper
• Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1.

  1998cited by this paper
• Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

  1998cited by this paper
• NMDA‐induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria

  1998cited by this paper
• Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

  1998cited by this paper
• Bcl-xL is an Antiapoptotic Regulator for Postnatal CNS Neurons

  1998cited by this paper
• p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF

  1998cited by this paper
• Activation of NF‐κB protects hippocampal neurons against oxidative stress‐induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

  1997cited by this paper
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

  1997cited by this paper
• MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

  1997cited by this paper
• Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor*

  1997cited by this paper
• Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands

  1997cited by this paper
• Ca2+ and Reactive Oxygen Species in Staurosporine‐Induced Neuronal Apoptosis

  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

  1997influential reference
• IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

  1997cited by this paper
• IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

  1997cited by this paper
• Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

  1996cited by this paper
• Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

  1996cited by this paper
• Neurotrophins Stimulate the Release of Dopamine from Rat Mesencephalic Neurons via Trk and p75Lntr Receptors*

  1996cited by this paper
• Marked diversity in the action of growth factors on N-methyl-D-aspartate-induced neuronal degeneration.

  1996cited by this paper
• Induction of cell death by endogenous nerve growth factor through its p75 receptor

  1996cited by this paper
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

  1996cited by this paper
• Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

  1996cited by this paper
• Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75

  1996cited by this paper
• Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF.

  1996cited by this paper
• Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

  1995cited by this paper
• Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

  1995cited by this paper
• bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

  1995cited by this paper
• Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.

  1994cited by this paper
• The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.

  1994cited by this paper
• p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.

  1994cited by this paper
• High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

  1994cited by this paper
• Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells.

  1994cited by this paper
• p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.

  1993cited by this paper
• Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture

  1993cited by this paper
• The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation.

  1993cited by this paper
• Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

  1993cited by this paper
• Nuclear uptake control of NF‐kappa B by MAD‐3, an I kappa B protein present in the nucleus.

  1993cited by this paper
• Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

  1992cited by this paper
• Binding of neurotrophin‐3 to its neuronal receptors and interactions with nerve growth factor and brain‐derived neurotrophic factor.

  1992influential reference
• High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

  1991cited by this paper
• Binding of brain-derived neurotrophic factor to the nerve growth factor receptor.

  1990influential reference
• Gene transfer and molecular cloning of the rat nerve growth factor receptor

  1987cited by this paper
• A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

  1986cited by this paper

• Unveiling the effect of Withania somnifera on neuronal cytoarchitecture and synaptogenesis: A combined in vitro and network pharmacology approach

  2022cites this paper
• Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

  2022cites this paper
• Receptors | Neurotrophin Receptor Signaling

  2021cites this paper
• Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia

  2019cites this paper
• Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF)

  2019cites this paper
• Investigation of Mature BDNF and proBDNF Signaling in a Rat Photothrombotic Ischemic Model

  2018cites this paper
• The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus.

  2018cites this paper
• Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies.

  2017cites this paper
• Résistances/sensibilisations aux anti-CD20 (rituximab) dans les lymphomes diffus à grandes cellules B (DLBCL)

  2016cites this paper
• Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence

  2015cites this paper
• Neurotrophins in the regulation of cellular survival and death.

  2014influential citation
• Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.

  2014cites this paper
• The biological functions and signaling mechanisms of the p75 neurotrophin receptor.

  2014cites this paper
• Alzheimer Aβ inhibition of eg5/kin5 reduces neurotrophin/ transmitter receptor function

  2014influential citation
• Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease

  2014cites this paper
• A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress*

  2014cites this paper
• Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling.

  2013cites this paper
• Der niedrigaffine Neurotrophinrezeptor p75NTR reduziert die Tumorigenität des Neuroblastoms in vitro und in vivo

  2013cites this paper
• Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice

  2013cites this paper
• Region-Specific Integration of Embryonic Stem Cell-Derived Neuronal Precursors into a Pre-Existing Neuronal Circuit

  2013cites this paper
• NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

  2013cites this paper
• NGF signaling in PC 12 cells : the cooperation of p 75 NTR with TrkA is needed for the activation of both mTORC 2 and the PI 3 K signalling cascade

  2013cites this paper
• The Ubiquitin Ligase Praja1 Reduces NRAGE Expression and Inhibits Neuronal Differentiation of PC12 Cells

  2013cites this paper
• Der niedrigaffine Neurotrophinrezeptor p75NTR reduziert die Tumorigenität des Neuroblastoms in vitro und in vivo

  2013cites this paper
• Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells

  2012cites this paper
• Glutamate attenuates IGF-1 receptor tyrosine phosphorylation in mouse brain: possible significance in ischemic brain damage.

  2012cites this paper
• P75 and phosphorylated c-Jun are differentially regulated in spinal motoneurons following axotomy in rats☆

  2012cites this paper
• The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

  2011cites this paper
• Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells

  2011cites this paper
• Neurotrophic Effects of a Cyanine Dye via the PI3K-Akt Pathway: Attenuation of Motor Discoordination and Neurodegeneration in an Ataxic Animal Model

  2011cites this paper
• Fetal–Neonatal Iron Deficiency Affects Neurotrophic Factor Expression, Neural Differentiation, and Neuroplasticity in the Rat Hippocampus

  2011cites this paper
• p 53-mediated neuronal cell death in ischemic brain injury

  2010cites this paper
• Die Rolle der Wechselwirkung von p53 und NF қB für den sekundären Hirnschaden nach Schädel-Hirn Trauma - eine tierexperimentelle Studie an der Maus

  2010cites this paper
• Signaling effect of amyloid-beta(42) on the processing of AbetaPP.

  2010cites this paper
• p53-mediated neuronal cell death in ischemic brain injury

  2010cites this paper
• NF-κΒ Signaling in Neurite Growth and Neuronal Survival

  2010cites this paper
• Rôle du NGF dans l’angiogenèse du cancer du sein

  2009cites this paper
• Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress.

  2009cites this paper
• Molecular mechanisms in schwann cell survival and death during peripheral nerve development, injury and disease

  2009cites this paper
• Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation

  2009cites this paper
• Differentiation induced by Achyrocline satureioides (Lam) infusion in PC12 cells

  2009cites this paper
• A possible physiological role of Abeta as a crosslinker

  2008cites this paper
• Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats.

  2008cites this paper
• The role of p53 in brain edema after 24 h of experimental subarachnoid hemorrhage in a rat model.

  2008cites this paper
• Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?

  2007cites this paper
• Neurotrophic factor regulation of gene expression in primary sensory neurons of the mouse

  2007cites this paper
• The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen.

  2007cites this paper
• Nerve growth factor neuroprotection of ethanol-induced neuronal death in rat cerebral cortex is age dependent.

  2007cites this paper
• Nerve Growth Factor Mediates Peripheral Sensitization

  2007influential citation
• Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in β-amyloid peptide-dependent cell death

  2007influential citation
• A cell‐biological model of p75NTR signaling

  2007cites this paper
• The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury.

  2007cites this paper
• The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus

  2006cites this paper
• Production of nerve growth factor by β‐amyloid‐stimulated astrocytes induces p75NTR‐dependent tau hyperphosphorylation in cultured hippocampal neurons

  2006cites this paper
• Nerve growth factor affects Ca2+ currents via the p75 receptor to enhance prolactin mRNA levels in GH3 rat pituitary cells

  2006cites this paper
• NF-κB in Neurons

  2006cites this paper
• NF-KB in Neurons: Behavioral and Physiologic Roles in Nervous System Function

  2006cites this paper
• Le facteur de croissance des nerfs NGF dans l'inflammation et le remodelage bronchique dans l'asthme

  2006cites this paper
• Behavioral and Physiologic Roles in Nervous System Function

  2005cites this paper
• Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.

  2005cites this paper
• NIBP, a Novel NIK and IKKβ-binding Protein That Enhances NF-κB Activation*

  2005cites this paper
• Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits.

  2005cites this paper
• The transcriptional response to hypoxic insult controlled by FRA-2.

  2005cites this paper
• The p75 neurotrophin receptor in human development and disease.

  2005cites this paper
• NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.

  2005cites this paper
• Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis

  2004cites this paper
• The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons.

  2004cites this paper
• A Functional Interaction between the p75 Neurotrophin Receptor Interacting Factors, TRAF6 and NRIF*

  2004cites this paper
• IGF-I prevents glutamate-induced motor neuron programmed cell death.

  2004cites this paper
• The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons

  2004cites this paper
• Sputa nerve growth factor forms a preferable substitute to mouse 7S-beta nerve growth factor.

  2004cites this paper
• Neurotrophin Signaling through the p75 Receptor Is Deficient in traf6-/- Mice

  2004cites this paper
• Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells.

  2004cites this paper
• The p75 neurotrophin receptor: multiple interactors and numerous functions.

  2004cites this paper
• NGF acts via p75 low‐affinity neurotrophin receptor and calpain inhibition to reduce UV neurotoxicity

  2004influential citation
• p75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid β Peptide Cytotoxicity

  2003cites this paper
• Molecular pathways in cerebral ischemia

  2003influential citation
• Molecular determinants of retinal ganglion cell development, survival, and regeneration.

  2003cites this paper
• Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

  2003cites this paper
• Nerve Growth Factor-induced Glutamate Release Is via p75 Receptor, Ceramide, and Ca2+ from Ryanodine Receptor in Developing Cerebellar Neurons*

  2003cites this paper
• Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

  2002cites this paper
• Cellular/molecular P75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid ␤ Peptide Cytotoxicity

  year unknowncites this paper