Regeneration of Free Reducing Glycans from Reductive Amination-Tagged Glycans by Oxone.

Glycans are usually fluorescently tagged by reductive amination for analytic tools. However, free reducing glycan regeneration is sometimes important and necessary for further structural or functional studies. Here, we introduce a new method for efficiently removing fluorescent tags from glycoconjugates by a simple treatment with Oxone. This method is proven to be fast and general after being tested on a series of common saccharides and widely used tags. We successfully achieved N-glycopeptide synthesis by using the regenerated glycans.

• Publication year

  2022

• Venue

  Journal of Organic Chemistry

• Publication date

  2022-02-10

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.joc.1c02709PMID 35143205PMCID PMC9228866
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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