Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Nature Metabolism

• Publication date

  2022-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s42255-021-00524-2PMID 35145325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long‐term expanding human airway organoids for disease modeling

  2019cited by this paper
• Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.

  2019cited by this paper
• Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

  2019cited by this paper
• GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism

  2019cited by this paper
• Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

  2018cited by this paper
• Glutamine metabolism in cancer therapy

  2018cited by this paper
• The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype

  2018cited by this paper
• Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.

  2018cited by this paper
• Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer

  2017cited by this paper
• Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

  2017cited by this paper
• Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.

  2016cited by this paper
• Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

  2016cited by this paper
• Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

  2016cited by this paper
• Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

  2016cited by this paper
• From Krebs to clinic: glutamine metabolism to cancer therapy

  2016cited by this paper
• Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

  2016cited by this paper
• The nuclear pore complex: understanding its function through structural insight

  2016cited by this paper
• Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.

  2015cited by this paper
• Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

  2015cited by this paper
• Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

  2015cited by this paper
• Nuclear pore proteins and the control of genome functions

  2015cited by this paper
• Myc induces expression of glutamine synthetase through promoter demethylation

  2015cited by this paper
• Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.

  2015cited by this paper
• Molecular architecture and mechanism of the anaphase-promoting complex

  2014cited by this paper
• Glutamine and cancer: cell biology, physiology, and clinical opportunities.

  2013cited by this paper
• The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.

  2013cited by this paper
• Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

  2012cited by this paper
• The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

  2012cited by this paper
• Systematic identification of genomic markers of drug sensitivity in cancer cells

  2012cited by this paper
• Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

  2012cited by this paper
• Cubism and the cell cycle: the many faces of the APC/C

  2011cited by this paper
• Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-β-TrCP, sequentially regulate glycolysis during the cell cycle

  2011cited by this paper
• Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non–Small-Cell Lung Cancer Patients

  2011cited by this paper
• Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells

  2011cited by this paper
• Cubism and the cell cycle: the many faces of the APC/C

  2011cited by this paper
• Characterization of the role of the tumor marker Nup88 in mitosis

  2010cited by this paper
• Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.

  2010cited by this paper
• E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

  2009cited by this paper
• c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• Abstract #LB-186: c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.

  2008cited by this paper
• To cell cycle, swing the APC/C.

  2008cited by this paper
• Cdc20: a WD40 activator for a cell cycle degradation machine.

  2007cited by this paper
• A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.

  2005cited by this paper
• Congenital glutamine deficiency with glutamine synthetase mutations.

  2005cited by this paper
• Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells.

  1998cited by this paper

• Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition

  2026cites this paper
• Glutamine Synthetase: Spotlighting the Emerging Roles in Tumor Progression and Therapeutic Avenues.

  2026cites this paper
• Characterization of Osborne-extracted proteins from black soldier fly (Hermetia illucens) larvae: Functional properties, allergenicity, bioactivities, and acute toxicity

  2026cites this paper
• Noncanonical UPR factor CREB3L2 drives immune evasion of triple-negative breast cancer through Hedgehog pathway modulation in T cells

  2025cites this paper
• PRDX6 Prevents NNMT Ubiquitination and Degradation as a Nonenzymatic Mechanism to Promote Ovarian Cancer Progression

  2025cites this paper
• Epigenetic modifications in early stage lung cancer: pathogenesis, biomarkers, and early diagnosis

  2025cites this paper
• HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

  2025cites this paper
• Myeloid Glutamine Synthetase Protects Against Acute Liver Injury in Mice Independent of Its Enzyme Activity

  2025cites this paper
• TFDP1 activates SPC25-mediated glutamine metabolism to repress anti-tumor immunity of NK cells in lung adenocarcinoma

  2025cites this paper
• GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis

  2025cites this paper
• Development of a theranostic tri-nuclear gadolinium(III) complex based on apoferritin for multitarget therapy of orthotopic glioma

  2025cites this paper
• Glutamine synthetase shields triple-negative breast cancer cells from ferroptosis in metastasis triggered by glutamine deprivation

  2025cites this paper
• Targeting glutamine catabolism suppresses eosinophil expansion and activation to alleviate allergic airway inflammation.

  2025cites this paper
• APC/C coactivators Cdh1 and Cdc20: Mechanistic insights into cancer progression and therapeutic opportunities.

  2025cites this paper
• Inhibition of glutamine synthetase enhances hepatocellular carcinoma radiosensitivity through ROS-induced excessive mitophagy

  2025cites this paper
• Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment

  2025cites this paper
• Metabolic syndrome-related gene signature for prognosis and immune microenvironment prediction in hepatocellular carcinoma

  2025influential citation
• Glutamine synthetase regulates the changes of vascular permeability in glioma induced by radiotherapy

  2025cites this paper
• Leveraging Cancer Metabolism to Translate into Effective Therapeutics.

  2025cites this paper
• Amino acids metabolism: a potential target for cancer treatment

  2025cites this paper
• Glutamine synthetase accelerates re-endothelialization of vascular grafts by mitigating endothelial cell dysfunction in a rat model.

  2024cites this paper
• NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer.

  2024cites this paper
• Metabolomics, Transcriptome and Single-Cell RNA Sequencing Analysis of the Metabolic Heterogeneity between Oral Cancer Stem Cells and Differentiated Cancer Cells

  2024cites this paper
• Amino acid metabolism in tumor biology and therapy

  2024cites this paper
• Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis.

  2024cites this paper
• Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis

  2024cites this paper
• Cellular and Genomic Instability Induced by the Herbicide Glufosinate-Ammonium: An In Vitro and In Vivo Approach

  2024cites this paper
• The Role and Treatment Strategies of Ammonia-Related Metabolism in Tumor Microenvironment.

  2024cites this paper
• Career pathways, part 12

  2023cites this paper
• Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids

  2023cites this paper
• Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy

  2023cites this paper
• Licensing instead of fueling: Glutamine synthetase promotes mitotic progression via a non-metabolic mechanism

  2023cites this paper
• The application of patient-derived organoid in the research of lung cancer

  2023cites this paper
• Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication.

  2023cites this paper
• A negative feedback loop between KLF9 and the EMT program dictates metastasis of hepatocellular carcinoma

  2023cites this paper
• Sijunzi Tang improves gefitinib resistance by regulating glutamine metabolism.

  2023cites this paper
• Management of Advanced Pancreatic Cancer through Stromal Depletion and Immune Modulation

  2022cites this paper
• Turbulence of glutamine metabolism in pan-cancer prognosis and immune microenvironment

  2022cites this paper
• Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review.

  2022cites this paper