Interferon epsilon and preterm birth subtypes; a new piece of the type I interferon puzzle during pregnancy?

Interferon epsilon (IFNε) is a unique type I IFN that is expressed in response to sex steroids. Studies suggest that type I IFNs regulate inflammation‐induced preterm birth (PTB), but no study has examined the role of IFNε in human pregnancy.

• Publication year

  2022

• Venue

  American Journal of Reproductive Immunology

• Publication date

  2022-02-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/aji.13526PMID 35147251PMCID PMC9978937
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Births in the United States, 2020.

  2021cited by this paper
• Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

  2021cited by this paper
• Circulating levels of IFN-γ, IL-1, IL-17 and IL-22 in pre-eclampsia: A systematic review and meta-analysis.

  2020cited by this paper
• Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

  2020cited by this paper
• Commentary on a combined approach to the problem of developing biomarkers for the prediction of spontaneous preterm labor that leads to preterm birth.

  2020cited by this paper
• Global burden of preterm birth

  2020cited by this paper
• Antiviral Inflammation during Early Pregnancy Reduces Placental and Fetal Growth Trajectories

  2019cited by this paper
• PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON.

  2019cited by this paper
• Accounting for missing data in statistical analyses: multiple imputation is not always the answer

  2019cited by this paper
• Interferon lambda protects the female reproductive tract against Zika virus infection

  2019cited by this paper
• Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus‐infected pregnant women: Results of a pilot study

  2018cited by this paper
• Relevance of placental type I interferon beta regulation for pregnancy success

  2018cited by this paper
• The 2018 Revision of the ISBER Best Practices: Summary of Changes and the Editorial Team's Development Process

  2018cited by this paper
• The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend.

  2017cited by this paper
• Preclinical evaluation of drugs to block inflammation-driven preterm birth

  2017cited by this paper
• Sensitivity Analysis in Observational Research: Introducing the E-Value

  2017cited by this paper
• Committee Opinion No. 700 Summary: Methods for Estimating the Due Date.

  2017cited by this paper
• Type I interferons regulate susceptibility to inflammation-induced preterm birth.

  2017cited by this paper
• The unique immunological and microbial aspects of pregnancy

  2017cited by this paper
• First and second trimester immune biomarkers in preeclamptic and normotensive women.

  2016cited by this paper
• Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.

  2016cited by this paper
• Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection‐Induced Preterm Birth

  2016cited by this paper
• Mechanistic Differences Leading to Infectious and Sterile Inflammation

  2016cited by this paper
• The role of sex hormones in immune protection of the female reproductive tract

  2015cited by this paper
• Spontaneous and indicated preterm birth subtypes: interobserver agreement and accuracy of classification.

  2014cited by this paper
• Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design

  2014cited by this paper
• Immune cells in term and preterm labor

  2014cited by this paper
• Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection

  2013cited by this paper
• If we know so much about preeclampsia, why haven't we cured the disease?

  2013cited by this paper
• Type I Interferon Protects against Pneumococcal Invasive Disease by Inhibiting Bacterial Transmigration across the Lung

  2013cited by this paper
• Regulation of type I interferon responses

  2013cited by this paper
• Redefining preeclampsia using placenta-derived biomarkers.

  2013cited by this paper
• Type I Interferon Induction during Influenza Virus Infection Increases Susceptibility to Secondary Streptococcus pneumoniae Infection by Negative Regulation of γδ T Cells

  2012cited by this paper
• Performance of Swabs, Lavage, and Diluents to Quantify Biomarkers of Female Genital Tract Soluble Mucosal Mediators

  2011cited by this paper
• Placental Viral Infection Sensitizes to Endotoxin‐Induced Pre‐Term Labor: A Double Hit Hypothesis

  2011cited by this paper
• Vaginal swab specimen processing methods influence performance of rapid semen detection tests: a cautionary tale.

  2010cited by this paper
• REVIEW ARTICLE: Immunology of Pre‐Eclampsia

  2010cited by this paper
• Viral ssRNA Induces First Trimester Trophoblast Apoptosis through an Inflammatory Mechanism

  2010cited by this paper
• Impaired interferon signaling is a common immune defect in human cancer

  2009cited by this paper
• The global burden of preterm birth.

  2009cited by this paper
• Intrauterine restriction (IUGR)

  2008cited by this paper
• Medically indicated preterm birth: recognizing the importance of the problem.

  2008cited by this paper
• Murine gammaherpesvirus 68: a model for the study of Epstein-Barr virus infections and related diseases.

  2007cited by this paper
• Menstrual cycle-dependent changes of Toll-like receptors in endometrium.

  2007cited by this paper
• Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle.

  2007cited by this paper
• Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth.

  2006cited by this paper
• Placental Abruption

  2006cited by this paper
• Comparison of Vaginal Cytokine Collection Methods

  2006cited by this paper
• IL-1β-Mediated Proinflammatory Responses Are Inhibited by Estradiol via Down-Regulation of IL-1 Receptor Type I in Uterine Epithelial Cells1

  2005cited by this paper
• Type I interferons and IRF-1 play a critical role in the control of a gammaherpesvirus infection.

  1999cited by this paper
• Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process.

  1999cited by this paper
• Placental Abruption

  1990cited by this paper
• Sexually transmitted disease surveillance.

  1982cited by this paper
• Immunology of pre-eclampsia.

  1978cited by this paper

• Decidual Cells Induce Release of Free and Exosome‐Bound Interferon Epsilon From Vaginal Epithelial Cells

  2025influential citation
• USE OF RECOMBINANT INTERFERON ALPHA-2B IN PATIENTS WITH VIRAL AND MIXED INFECTIONS TRANSMITTED THROUGH SEXUALLY TRANSMITTED

  2025cites this paper
• CÉLULAS NK UTERINAS E PERIFÉRICAS NO ABORTO EXPONTÂNEO RECORRENTE: REVISÃO SISTEMÁTICA QUALITATIVA DE MECANISMOS BIOMARCADORES (KIR/HLA-C) E TERAPIAS IMUNOMODULADORAS (2010-2025)

  2025cites this paper
• Interferon Epsilon: Properties and Functions.

  2024cites this paper
• Functional interferon‐epsilon gene polymorphisms and sexually transmitted infections of the endometrium

  2023cites this paper
• Defining a role for Interferon Epsilon in normal and complicated pregnancies

  2022cites this paper
• The regulation of antiviral activity of interferon epsilon

  2022cites this paper