Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice

No abstract is available for this paper.

• Publication year

  2022

• Venue

  Translational Stroke Research

• Publication date

  2022-02-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12975-022-00994-wPMID 35146631PMCID PMC10114538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice

  2021cited by this paper
• Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

  2021cited by this paper
• Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.

  2020cited by this paper
• Neurogenesis After Stroke: A Therapeutic Perspective

  2020influential reference
• Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

  2019cited by this paper
• Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

  2019cited by this paper
• Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

  2019cited by this paper
• Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice

  2018cited by this paper
• Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis

  2017cited by this paper
• Mechanisms of Axonal Damage and Repair after Central Nervous System Injury

  2017cited by this paper
• Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis

  2017cited by this paper
• Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

  2017cited by this paper
• A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

  2016cited by this paper
• Acute Blockage of Notch Signaling by DAPT Induces Neuroprotection and Neurogenesis in the Neonatal Rat Brain After Stroke

  2016cited by this paper
• A Notch-Gli2 axis sustains Hedgehog responsiveness of neural progenitors and Müller glia.

  2016cited by this paper
• Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.

  2016cited by this paper
• A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

  2015cited by this paper
• An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

  2014cited by this paper
• Cognitive impairment and memory dysfunction after a stroke diagnosis: a post-stroke memory assessment

  2014cited by this paper
• Frequency of Anxiety after Stroke: A Systematic Review and Meta-Analysis of Observational Studies

  2013cited by this paper
• Effects of Androgens on Early Post-ischemic Neurogenesis in Mice

  2013cited by this paper
• Titration of GLI3 Repressor Activity by Sonic Hedgehog Signaling Is Critical for Maintaining Multiple Adult Neural Stem Cell and Astrocyte Functions

  2013influential reference
• Isolation of multipotent neural stem or progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse

  2012cited by this paper
• Adult neurogenesis in the mammalian brain: significant answers and significant questions.

  2011cited by this paper
• Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.

  2011cited by this paper
• Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

  2010cited by this paper
• Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress

  2010cited by this paper
• Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients.

  2010cited by this paper
• Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

  2010cited by this paper
• Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain

  2010influential reference
• Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats.

  2010cited by this paper
• Adult hippocampal neurogenesis is involved in anxiety-related behaviors

  2009cited by this paper
• Notch signaling and neurogenesis in normal and stroke brain.

  2009cited by this paper
• Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback.

  2009cited by this paper
• Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory

  2009cited by this paper
• A role for adult TLX-positive neural stem cells in learning and behaviour

  2008cited by this paper
• Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal

  2007cited by this paper
• Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

  2006cited by this paper
• In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

  2005cited by this paper
• Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

  2005cited by this paper
• Progesterone Enhances Functional Recovery after Middle Cerebral Artery Occlusion in Male Mice

  2004cited by this paper
• Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

  2003cited by this paper
• Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

  2003cited by this paper
• Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone

  2002cited by this paper
• Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

  2002cited by this paper
• Mammalian neural stem cells.

  2000cited by this paper
• The specification of neuronal identity by graded Sonic Hedgehog signalling.

  1999cited by this paper
• Patterns and dynamics of SVZ cell migration in the postnatal forebrain: monitoring living progenitors in slice preparations.

  1999cited by this paper
• Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

  1996cited by this paper
• Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

  1996cited by this paper
• Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.

  1995cited by this paper
• Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites.

  1994cited by this paper
• Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm

  year unknowncited by this paper

• A transcriptomic resource for glial GABA-associated ASH neuronal aging and candidate pathways

  2026cites this paper
• Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice

  2026cites this paper
• Integrated analysis of spatial and single-cell profiles reveals cell type-specific regulation of synaptic plasticity in human brain aging.

  2026cites this paper
• Adult hippocampal neurogenesis: New avenues for treatment of brain disorders

  2025cites this paper
• Cell type–dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migration

  2025cites this paper
• Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair

  2025cites this paper
• Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights.

  2025cites this paper
• Effects of Clobetasol in an Aging Mouse Model of Spinal Cord Hemisection

  2025cites this paper
• Developmental Exposure to Nonylphenol Leads to Depletion of the Neural Precursor Cell Pool in the Hippocampal Dentate Gyrus.

  2024cites this paper
• OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage.

  2024cites this paper
• Generation of a Deep Mouse Brain Spectral Library for Transmembrane Proteome Profiling in Mental Disease Models

  2024cites this paper
• Expression and Functional Analysis of the Smo Protein in Apis mellifera

  2024cites this paper
• Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway

  2024cites this paper
• Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

  2024cites this paper
• Purmorphamine Alters Anxiety-Like Behavior and Expression of Hedgehog Cascade Components in Rat Brain after Alcohol Withdrawal

  2024cites this paper
• Olfactory bulb neurogenesis depending on signaling in the subventricular zone.

  2023cites this paper
• Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases

  2023cites this paper
• Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration

  2023cites this paper
• Adult neurogenesis: a real hope or a delusion?

  2023influential citation
• Endogenous Neural Stem Cell–induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives

  2022cites this paper
• Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons

  2022cites this paper
• The role of Hedgehog and Notch signaling pathway in cancer

  2022cites this paper
• Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

  2022cites this paper
• Effects of hypomagnetic field on adult hippocampal neurogenic niche and neurogenesis in mice

  2022cites this paper