Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)

Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. Although commonly used in avian medicine, limited pharmacokinetic (PK) data in domestic and companion birds are available. In this study, PK parameters and absolute oral bioavailability expressed as percentage (F%) of celecoxib (10 mg/kg BW), mavacoxib (4 mg/kg BW) and meloxicam (1 mg/kg BW) were determined following single oral (PO) and intravenous (IV) administration to cockatiels (Nymphicus hollandicus). The drugs were quantified in plasma by liquid chromatography-tandem mass spectrometry. Data were processed using the nonlinear mixed effects (NLME) approach. In contrast to celecoxib (T1/2el = 0.88 h) and meloxicam (T1/2el = 0.90 h), mavacoxib has a prolonged elimination half-life (T1/2el = 135 h) following oral administration of a commercial formulation (CF). High to complete oral absorption was observed following oral administration of celecoxib (F% = 56–110%) and mavacoxib (F% = 111–113%), CF and standard solutions, respectively. In contrast, the F% of meloxicam was low (F% = 11%). Based on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib and meloxicam. However, pharmacodynamic and safety studies are necessary to further investigate the use of these NSAIDs in cockatiels.

• Publication year

  2017

• Venue

  Scientific Reports

• Publication date

  2017-09-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/s41598-017-12159-zPMID 28947805PMCID 5612971
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• : A Review of the

  2018cited by this paper
• Pharmacokinetics of meloxicam after intravenous, intramuscular and oral administration of a single dose to African grey parrots (Psittacus erithacus)

  2017cited by this paper
• Randomized controlled trial

  2016cited by this paper
• Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor).

  2016cited by this paper
• Differences in NSAID Toxicity inFour Avian Species

  2016cited by this paper
• Niet-steroïdale, anti-inflammatoire geneesmiddelen bij vogels: farmacokinetiek, farmacodynamiek en toxiciteit

  2016cited by this paper
• Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie

  2016cited by this paper
• Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

  2015cited by this paper
• Pattern Recognition in Pharmacokinetic Data Analysis

  2015cited by this paper
• Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species

  2015cited by this paper
• Flupirtine: intravenous and oral pharmacokinetics in the donkey

  2015cited by this paper
• The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome

  2015cited by this paper
• Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review.

  2015cited by this paper
• Bird-Specific Considerations

  2014cited by this paper
• Pharmacokinetics of a Single Dose of Intravenous and Oral Meloxicam in Red-tailed Hawks (Buteo jamaicensis) and Great Horned Owls (Bubo virginianus)

  2013cited by this paper
• Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis).

  2013cited by this paper
• Meloxicam Treatment in Cockatiels (Nymphicus hollandicus) Infected With Avian Bornavirus

  2013cited by this paper
• Anesthesia and Analgesia in Birds

  2012cited by this paper
• Avian analgesia.

  2011cited by this paper
• Quantitative determination of T-2 toxin, HT-2 toxin, deoxynivalenol and deepoxy-deoxynivalenol in animal body fluids using LC-MS/MS detection.

  2011cited by this paper
• Population pharmacokinetics of mavacoxib in osteoarthritic dogs.

  2011cited by this paper
• Review of the applications of different analytical techniques for coxibs research.

  2011cited by this paper
• The Isolation, Pathogenesis, Diagnosis, Transmission, and Control of Avian Bornavirus and Proventricular Dilatation Disease

  2010cited by this paper
• Recognition and Alleviation of Pain in Laboratory Animals

  2010cited by this paper
• Advanced Diagnostic Approaches and Current Management of Proventricular Dilatation Disease

  2010cited by this paper
• Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana).

  2010cited by this paper
• The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs.

  2010cited by this paper
• Pharmacokinetics of intravenous and oral meloxicam in ruminant calves.

  2009cited by this paper
• A Quantitative Enterohepatic Circulation Model

  2009cited by this paper
• Selected pharmacokinetic parameters for Cefovecin in hens and green iguanas.

  2009cited by this paper
• Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.

  2009cited by this paper
• Veterinary Drug Residues

  2008cited by this paper
• The Use of Analgesics in Birds, Reptiles, and Small Exotic Mammals

  2006cited by this paper
• Pharmacokinetics and pharmacodynamics of cefovecin in dogs.

  2006cited by this paper
• Pharmacokinetics of meloxicam in plasma and urine of horses.

  2004cited by this paper
• Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest.

  2004cited by this paper
• Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species.

  2003cited by this paper
• Gastrointestinal effects of NSAIDs and coxibs.

  2003cited by this paper
• Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption.

  2001cited by this paper
• Effects of Celecoxib, a Novel Cyclooxygenase‐2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial

  2000cited by this paper
• Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human

  1999cited by this paper
• Pharmacokinetics of meloxicam in animals and the relevance to humans.

  1998cited by this paper
• Effect of Food on the Pharmacokinetics of Meloxicam after Oral Administration

  1995cited by this paper
• Pharmacokinetics and metabolic pattern after intravenous infusion and oral administration to healthy subjects.

  1995cited by this paper
• Prozentuales und logarithmisches Verfahren zur Berechnung von Eichkurven

  1974cited by this paper

• Preclinical Pharmacokinetic Assessment of a Promising Vasorelaxant, Analgesic, and Anti‐Inflammatory Prototype 5‐[1‐(4‐Fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) Through Selective Bioanalytical HPLC‐PDA‐Based Method

  2025cites this paper
• The avian respiratory system: implications for anaesthesia

  2025cites this paper
• Pharmacokinetic evaluation of oral deracoxib in geese (Anser anser domesticus).

  2024cites this paper
• Treatment of Gastrointestinal Infectious Diseases in Exotic Animals.

  2024cites this paper
• Pain Management for Gastrointestinal Conditions in Exotic Animals.

  2024cites this paper
• Benchtop 19F Nuclear Magnetic Resonance (NMR) Spectroscopy-Optimized Knorr Pyrazole Synthesis of Celecoxib and Mavacoxib, 3-(Trifluoromethyl) Pyrazolyl Benzenesulfonamides, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

  2024cites this paper
• Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats

  2023cites this paper
• [Methods of analgesia and euthanasia in backyard poultry].

  2023cites this paper
• Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus).

  2023cites this paper
• Regiocontrolled Synthesis of 1-Substituted-3(5)-carboxyalkyl-1H-pyrazoles Using Trichloromethyl Enones

  2023cites this paper
• Pharmacokinetics of mavacoxib in New Zealand White rabbits (Oryctolagus cuniculus).

  2023cites this paper
• Treatment of Pain in Birds.

  2023cites this paper
• A Critical Review of the Pharmacokinetics, Pharmacodynamics, and Safety Data of Antibiotics in Avian Species

  2022cites this paper
• Transition-metal-free electrochemical oxidative C(sp2)-H trifluoromethylation of aryl aldehyde hydrazones.

  2022cites this paper
• Pharmacokinetics and bioavailability of meloxicam in rainbow trout (Oncorhynchus mykiss) broodstock following intravascular, intramuscular, and oral administrations.

  2021cites this paper
• Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)

  2021influential citation
• Comparative effects of meloxicam and dexamethasone in chickens with experimental systemic inflammation: clinical outcome and cardiovascular parameters

  2021cites this paper
• Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica).

  2021cites this paper
• Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar).

  2021cites this paper
• Pharmacokinetics of a Single Dose of Oral Meloxicam in Rehabilitated Wild Brown Pelicans (Pelecanus occidentalis)

  2020cites this paper
• Comparison of the Clinical Efficacy of Celebrex and Celecoxib for Pain Relief after Periodontal Surgeries

  2020cites this paper
• Perioperative pharmacokinetics and pharmacodynamics of meloxicam in emus (Dromaius novaehollandiae) of different age groups using nonlinear mixed effect modelling.

  2020cites this paper
• PHARMACOKINETICS OF ORAL MAVACOXIB IN CARIBBEAN FLAMINGOS (PHOENICOPTERUS RUBER RUBER)

  2020influential citation
• General Principles of Analgesia and Anesthesia in Wildlife

  2019cites this paper
• Treatment With Nonsteroidal Anti-In fl ammatory Drugs Fails To Ameliorate Pathology In Cockatiels Experimentally Infected With Parrot Bornavirus-2

  2019cites this paper
• Treatment With Nonsteroidal Anti-Inflammatory Drugs Fails To Ameliorate Pathology In Cockatiels Experimentally Infected With Parrot Bornavirus-2

  2019cites this paper
• Pharmacokinetics and Safety of Intramuscular Meloxicam in Zebra Finches (Taeniopygia guttata).

  2019cites this paper
• Analgesic Efficacy of Tramadol Compared With Meloxicam in Ducks (Cairina moschata domestica) Evaluated by Ground-Reactive Forces

  2019cites this paper
• Development of an in Vivo Lipopolysaccharide Inflammation Model to Study the Pharmacodynamics of COX-2 Inhibitors Celecoxib, Mavacoxib, and Meloxicam in Cockatiels (Nymphicus hollandicus)

  2019cites this paper
• PHARMACOKINETICS OF ORAL GABAPENTIN IN CARIBBEAN FLAMINGOS (PHOENICOPTERUS RUBER RUBER)

  2018cites this paper