Death of CD4+ T-Cell Lines Caused by Human Immunodeficiency Virus Type 1 Does Not Depend on Caspases or Apoptosis

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Virology

• Publication date

  2002-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.76.10.5094-5107.2002PMID 11967325PMCID PMC136143
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytopathic Killing of Peripheral Blood CD4+ T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env

  2002cited by this paper
• Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms.

  2000cited by this paper
• Cross-Talk between Two Cysteine Protease Families

  2000cited by this paper
• Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

  2000influential reference
• Ocular toxoplasmosis: new directions for clinical investigation

  2000cited by this paper
• Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies.

  2000cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• Moloney Murine Leukemia Virus-Induced Preleukemic Thymic Atrophy and Enhanced Thymocyte Apoptosis Correlate with Disease Pathogenicity

  1999cited by this paper
• Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?

  1999cited by this paper
• Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8

  1999cited by this paper
• Staining apoptosis in paraffin sections. Advantages and limits.

  1999cited by this paper
• FADD is required for multiple signaling events downstream of the receptor Fas.

  1999cited by this paper
• Sendai Virus Infection Induces Apoptosis through Activation of Caspase-8 (FLICE) and Caspase-3 (CPP32)

  1999cited by this paper
• U937 cells overexpressing bcl-xl are resistant to human immunodeficiency virus-1-induced apoptosis and human immunodeficiency virus-1 replication.

  1999cited by this paper
• Both necrosis and apoptosis contribute to HIV-1-induced killing of CD4 cells.

  1999cited by this paper
• Morphologic criteria and detection of apoptosis

  1999cited by this paper
• Caspase structure, proteolytic substrates, and function during apoptotic cell death

  1999cited by this paper
• Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.

  1999cited by this paper
• Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis

  1998cited by this paper
• HIV-1 Directly Kills CD4+ T Cells by a Fas-independent Mechanism

  1998cited by this paper
• Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*

  1998cited by this paper
• Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.

  1998cited by this paper
• Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes

  1998cited by this paper
• Bcl-2 family proteins and mitochondria.

  1998cited by this paper
• Fas/FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV-1 infection in vitro.

  1998cited by this paper
• Dual role of HIV Tat in regulation of apoptosis in T cells.

  1997cited by this paper
• Caspases and caspase inhibitors.

  1997cited by this paper
• HIV‐induced apoptosis of activated primary CD4+ T lymphocytes is not mediated by Fas–Fas ligand

  1997cited by this paper
• The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis

  1997cited by this paper
• Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways.

  1997cited by this paper
• Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.

  1997cited by this paper
• A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis

  1997influential reference
• Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

  1997cited by this paper
• Caspases: killer proteases.

  1997cited by this paper
• Apoptosis in AIDS.

  1997cited by this paper
• Monitoring early cellular responses in apoptosis is aided by the mitochondrial membrane protein-specific monoclonal antibody APO2.7.

  1997cited by this paper
• A new reporter cell line to monitor HIV infection and drug susceptibility in vitro.

  1997cited by this paper
• D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis (*)

  1996influential reference
• Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells.

  1996cited by this paper
• A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells.

  1996cited by this paper
• Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1

  1996influential reference
• Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

  1995cited by this paper
• A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.

  1995cited by this paper
• Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

  1995cited by this paper
• Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.

  1995cited by this paper
• Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection

  1995cited by this paper
• Identification of dying cells--in situ staining.

  1995cited by this paper
• Anatomical methods in cell death.

  1995cited by this paper
• HIV‐1 Tat potentiates TNF‐induced NF‐kappa B activation and cytotoxicity by altering the cellular redox state.

  1995cited by this paper
• Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

  1995cited by this paper
• Viral dynamics in human immunodeficiency virus type 1 infection

  1995cited by this paper
• Tat‐expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus‐type 1 (HIV ‐1) infection

  1995cited by this paper
• Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

  1995cited by this paper
• The Fas death factor

  1995cited by this paper
• Identification and characterization of a new member of the TNF family that induces apoptosis.

  1995cited by this paper
• Induction of developmentally programmed cell death and activation of HIV by sodium butyrate.

  1994cited by this paper
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

  1993cited by this paper
• Apoptosis in AIDS.

  1993cited by this paper
• Programmed death of T cells in HIV-1 infection.

  1992influential reference
• Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

  1992cited by this paper
• Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

  1992cited by this paper
• Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

  1992cited by this paper
• Phospholipid binding of annexin V: effects of calcium and membrane phosphatidylserine content.

  1992cited by this paper
• Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals

  1992cited by this paper
• Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

  1991cited by this paper
• The cytopathic effect of HIV is associated with apoptosis.

  1991cited by this paper
• The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.

  1988cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986cited by this paper
• Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

  1980cited by this paper

• The HIV-1 vpr R77Q Mutant Induces Apoptosis, G2 Cell Cycle Arrest, and Lower Production of Pro-Inflammatory Cytokines in Human CD4+ T Cells

  2024cites this paper
• Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity

  2023cites this paper
• An overview of “Chronic viral infection and cancer, openings for vaccines” virtual symposium of the TechVac Network - December 16-17, 2021

  2022cites this paper
• HIV‐induced bystander cell death in astrocytes requires cell‐to‐cell viral transmission

  2022cites this paper
• Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus

  2020cites this paper
• Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells ex vivo

  2020cites this paper
• Progress in Microbes and Molecular Biology

  2020cites this paper
• Vpr R36W and R77Q Mutations Alter HIV-1 Replication and Cytotoxicity in T Lymphocytes

  2020cites this paper
• Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics

  2020cites this paper
• The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells

  2020cites this paper
• Oncosis

  2018cites this paper
• Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

  2017cites this paper
• Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers

  2016cites this paper
• A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: synthesis and characterization of physical and toxicological properties.

  2015cites this paper
• Therapeutic exploitation of necroptosis for cancer therapy.

  2014cites this paper
• Necroptosis, in vivo detection in experimental disease models.

  2014influential citation
• Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

  2014cites this paper
• From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.

  2013cites this paper
• The mechanism of necroptosis in normal and cancer cells

  2013cites this paper
• DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4+ T Cells Infected with HIV

  2013cites this paper
• Regulation of Theiler’s Virus Induced Cell Death

  2013cites this paper
• Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.

  2012cites this paper
• Oncosis: an important non-apoptotic mode of cell death.

  2012cites this paper
• The activation and dynamics of cytokine expression by CD4+ T cells and AIDS progression in HIV-1-infected Chinese individuals.

  2012cites this paper
• Exposed Hydrophobic Residues in Human Immunodeficiency Virus Type 1 Vpr Helix-1 Are Important for Cell Cycle Arrest and Cell Death

  2011cites this paper
• Many stimuli pull the necrotic trigger, an overview

  2011cites this paper
• To kill or be killed: how viruses interact with the cell death machinery

  2010cites this paper
• Protein Kinase A Phosphorylation Activates Vpr-Induced Cell Cycle Arrest during Human Immunodeficiency Virus Type 1 Infection

  2010cites this paper
• Model with two types of CTL regulation and experiments on CTL dynamics.

  2010cites this paper
• Current strategies and limitations of HIV vaccines.

  2010cites this paper
• Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

  2010cites this paper
• Implications of the release of high-mobility group box 1 protein from dying cells during human immunodeficiency virus type 1 infection in vitro.

  2010cites this paper
• Necrosis: Molecular Mechanisms and Physiological Roles

  2009cites this paper
• HMBG-1 and other soluble factors in HIV-1 pathogenesis

  2009cites this paper
• Vpr and its interactions with cellular proteins.

  2009cites this paper
• Human Immunodeficiency Virus

  2009cites this paper
• HIV-1 viral genes and mitochondrial apoptosis

  2008cites this paper
• HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-Infected Cells

  2008cites this paper
• Molecular mechanisms and pathophysiology of necrotic cell death.

  2008cites this paper
• Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women.

  2007cites this paper
• Vpr Cytopathicity Independent of G 2 /M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4 (cid:1) T Cells (cid:1)

  2007cites this paper
• Vpr Cytopathicity Independent of G2/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4+ T Cells

  2007cites this paper
• The Yersinia Effector Protein YpkA Induces Apoptosis Independently of Actin Depolymerization1

  2007influential citation
• Molecular and immunogenic analysis of Jembrana disease virus Tat

  2006cites this paper
• The measurement of apoptosis in HIV-1 infection

  2006cites this paper
• Necrotic death as a cell fate.

  2006cites this paper
• HIV replication elicits little cytopathic effects in vivo: Analysis of surrogate markers for virus production, cytotoxic T cell response and infected cell death

  2006cites this paper
• The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest.

  2006cites this paper
• The Biology of Caspases

  2006cites this paper
• The humoral immune response to HIV-1: Consequences for vaccine design.

  2005cites this paper
• Analysis of Human Immunodeficiency Virus Cytopathicity by Using a New Method for Quantitating Viral Dynamics in Cell Culture

  2005cites this paper
• Mechanisms of HIV-Infected vs. Uninfected T Cell Killing

  2005cites this paper
• Apoptosis in Organ Culture and Animal Models of HIV Disease

  2005cites this paper
• Nonapoptotic HIV-Induced T Cell Death

  2005cites this paper
• Apoptosis induced in synchronized human immunodeficiency virus type 1-infected primary peripheral blood mononuclear cells is detected after the peak of CD4+ T-lymphocyte loss and is dependent on the tropism of the gp120 envelope glycoprotein.

  2004cites this paper
• CD8+ T-cells: function and response to HIV infection.

  2004cites this paper
• Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads.

  2004cites this paper
• R5 HIV gp120‐mediated cellular contacts induce the death of single CCR5‐expressing CD4 T cells by a gp41‐dependent mechanism

  2004cites this paper
• Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.

  2004cites this paper
• Monitoring caspase activity in living cells using fluorescent proteins and flow cytometry.

  2004cites this paper
• Cell-surface-expressed HIV-1 envelope induces the death of CD4 T cells during GP41-mediated hemifusion-like events.

  2003cites this paper
• Molecular regulation of T lymphocyte homeostasis in the healthy and diseased immune system

  2003cites this paper
• The Vpu Protein of Human Immunodeficiency Virus Type 1 Plays a Protective Role against Virus-Induced Apoptosis in Primary CD4+ T Lymphocytes

  2003cites this paper
• Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death.

  2003cites this paper
• Mitochondria in HIV-1-induced apoptosis.

  2003cites this paper
• PHYSIOLOGICAL SIGNIFICANCE OF APOPTOSIS DURING ANIMAL VIRUS INFECTION

  2003cites this paper
• HIV/host interactions: new lessons from the Red Queen's country.

  2002cites this paper
• Cytopathic Killing of Peripheral Blood CD4+ T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env

  2002cites this paper
• International Journal of Molecular Sciences the Hiv-1 Vpr Protein: a Multifaceted Target for Therapeutic Intervention

  year unknowncites this paper