Biologically Safe, Versatile, and Smart Bismuthene Functionalized with a Drug Delivery System Based on Red Phosphorus Quantum Dots for Cancer Theranostics.

Two-dimensional nanomaterials are currently attracting widespread attention for cancer therapy. However, high toxicity, insensitivity to external stimuli and single therapeutic modality are still key issues hindering their clinical application. Therefore, the construction of a secure, intelligent and versatile nanocomposite is necessary to meet clinical expectations. Herein, we developed a nanocomposite of Bi@RP-PEG-DOX with 2D bismuthene loaded with 0D red phosphorus quantum dots and DOX. The nanocomposite with DOX loading capacity (~250%) and photothermal conversion efficiency (~54%) showed synergistic photothermal and photodynamic effects and a sensitive response of drug release to the acidic tumor microenvironment or NIR Ⅱ laser irradiation. In particular, based on the Bi and RP, the nanocomposite exhibits good biosafety. Moreover, with the X-ray attenuation properties of bismuth, the nanocomposite serves as an excellent CT contrast agent, providing potential to perform CT-guided therapy. Overall, this work provides a promising, biosafe and synergistic strategy for clinical nanomedicine.

• Publication year

  2022

• Venue

  Angewandte Chemie

• Publication date

  2022-03-07

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1002/anie.202117679PMID 35257450
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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