Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Behavioural Pharmacology

• Publication date

  2011-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/FBP.0b013e32834d13a2PMID 21971021PMCID PMC3220419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination.

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• Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor.

  2009influential reference
• Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain

  2008cited by this paper
• Effect of a metabotropic glutamate receptor 5 antagonist, MPEP, on the nociceptive response induced by intrathecal injection of excitatory aminoacids, substance P, bradykinin or cytokines in mice.

  2008cited by this paper
• Morphine in Combination with Metabotropic Glutamate Receptor Antagonists on Schedule-Controlled Responding and Thermal Nociception

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• Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.

  2008cited by this paper
• Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats.

  2008cited by this paper
• Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)

  2008cited by this paper
• Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists.

  2007cited by this paper
• Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models.

  2007cited by this paper
• Mechanical, thermal and formalin‐induced nociception is differentially altered in 5‐HT1A−/−, 5‐HT1B−/−, 5‐HT2A−/−, 5‐HT3A−/− and 5‐HTT−/− knock‐out male mice

  2007cited by this paper
• Interactions between an N-Methyl-D-aspartate Antagonist and Low-Efficacy Opioid Receptor Agonists in Assays of Schedule-Controlled Responding and Thermal Nociception

  2006cited by this paper
• Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.

  2006influential reference
• Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A‐841720, a novel non‐competitive mGluR1 receptor antagonist

  2006cited by this paper
• Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats.

  2006influential reference
• Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

  2006cited by this paper
• Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats.

  2006cited by this paper
• Dextromethorphan differentially affects opioid antinociception in rats

  2005cited by this paper
• NMDA antagonist modulation of morphine antinociception in female vs. male rats.

  2005cited by this paper
• MorphiDex® (morphine sulfate/dextromethorphan hydrobromide combination) in the treatment of chronic pain: Three multicenter, randomized, double‐blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance

  2005cited by this paper
• mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity.

  2005cited by this paper
• Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.

  2004cited by this paper
• Modulation of morphine analgesia by site‐specific N‐methyl‐d‐aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time

  2004influential reference
• Up‐regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia

  2003cited by this paper
• Capsaicin-Induced Hyperalgesia and μ-Opioid-Induced Antihyperalgesia in Male and Female Fischer 344 Rats

  2003cited by this paper
• Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors.

  2003cited by this paper
• The Competitive N-Methyl-d-aspartate Receptor Antagonist (-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid (LY235959) Potentiates the Antinociceptive Effects of Opioids That Vary in Efficacy at the μ-Opioid Receptor

  2003cited by this paper
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  2003cited by this paper
• Effects of diltiazem and MK-801 on morphine analgesia and pharmacokinetics in mice.

  2002cited by this paper
• Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist.

  2002influential reference
• Peripheral Group II Metabotropic Glutamate Receptors (mGluR2/3) Regulate Prostaglandin E2-Mediated Sensitization of Capsaicin Responses and Thermal Nociception

  2002cited by this paper
• Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice

  2002influential reference
• Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats.

  2002influential reference
• The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity.

  2002cited by this paper
• mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C.

  2001cited by this paper
• Animal models of nociception.

  2001cited by this paper
• Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats

  2001cited by this paper
• Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

  2001cited by this paper
• mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

  2001cited by this paper
• MorphiDex (MS:DM) double-blind, multiple-dose studies in chronic pain patients.

  2000cited by this paper
• Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord

  2000cited by this paper
• Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn

  1999cited by this paper
• NMDA and opioid receptors: their interactions in antinociception, tolerance and neuroplasticity.

  1999cited by this paper
• Involvement of spinal NMDA receptors in capsaicin-induced nociception.

  1998cited by this paper
• Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.

  1997cited by this paper
• Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.

  1992cited by this paper
• Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.

  1992influential reference
• Manual of pharmacologic calculations with computer programs

  1982cited by this paper
• Manual of Pharmacologic Calculations

  1981cited by this paper

• Multitarget Ligands that Comprise Opioid/Nonopioid Pharmacophores for Pain Management: Current State of the Science.

  2024cites this paper
• Opioids induce bidirectional synaptic plasticity in a brainstem pain centre in the rat.

  2023cites this paper
• TailTimer: A device for automating data collection in the rodent tail immersion assay

  2021cites this paper
• TailTimer: an open-source device for automating the rodent tail immersion assay

  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction

  2016cites this paper
• Metabotropic Glutamate Receptors in Central Nervous System Diseases.

  2016cites this paper
• Peripheral scaffolding and signaling pathways in inflammatory pain.

  2015cites this paper
• Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice

  2014cites this paper
• Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain.

  2013cites this paper
• Endogenous opiates and behavior: 2011.

  2012cites this paper
• A competitive NMDA receptor antagonist potentiates the effects of morphine on spatial and discrimination learning

  2009cites this paper