SCIENCE@home

CRNDE: A valuable long noncoding RNA for diagnosis and therapy of solid and hematological malignancies

Xuefei Ma,W. Jin,Chaoxian Zhao,Xuefeng Wang,Kankan Wang

Published 2022 in Molecular Therapy: Nucleic Acids

ABSTRACT

Colorectal neoplasia differentially expressed (CRNDE) is an oncogenic long noncoding RNA (lncRNA). Increased CRNDE expression was initially discovered in colorectal cancer and then in a variety of solid tumors and hematological malignancies. CRNDE participates in multiple biological processes, such as cell proliferation, differentiation, migration, and apoptosis. CRNDE has been shown to modulate target gene expression through multiple mechanisms, including transcriptional regulation, post-transcriptional regulation, and competition for microRNA (miRNA) binding. In this review, we summarize the evidence that supports CRNDE in the diagnosis and prognosis predicting of cancers. The functional roles and molecular mechanisms of CRNDE are further described for major types of solid tumors and hematological malignancies. The therapeutic potential of CRNDE as a target for research and development is also discussed.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-91 of 91 references · Page 1 of 1

CITED BY

Showing 1-21 of 21 citing papers · Page 1 of 1