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Strong Inhibition of Xenografted Tumor Growth by Low-Level Doses of [32P]ATP

Yulan Cheng,Jian Yang,Rachana Agarwal,G. Green,R. Mease,M. Pomper,S. Meltzer,J. Abraham

Published 2011 in OncoTarget

ABSTRACT

The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [32P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [32P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [32P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.

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