Allosteric properties of G protein-coupled receptor oligomers.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Pharmacology and Therapeutics

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.PHARMTHERA.2007.06.004PMID 17655934
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transducin Activation by Nanoscale Lipid Bilayers Containing One and Two Rhodopsins*

  2007cited by this paper
• BRET analysis of GPCR oligomerization: newer does not mean better

  2007cited by this paper
• A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

  2007cited by this paper
• Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox.

  2006cited by this paper
• GPCR modulation by RAMPs.

  2006cited by this paper
• Functional and Structural Characterization of Rhodopsin Oligomers*

  2006cited by this paper
• FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

  2006cited by this paper
• The Two-State Dimer Receptor Model: A General Model for Receptor Dimers

  2006cited by this paper
• Computational methods in drug design: Modeling G protein-coupled receptor monomers, dimers, and oligomers

  2006cited by this paper
• A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer

  2006cited by this paper
• Allosteric Modulation of Binding Properties between Units of Chemokine Receptor Homo- and Hetero-Oligomers

  2006cited by this paper
• Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding

  2006cited by this paper
• Asymmetric conformational changes in a GPCR dimer controlled by G‐proteins

  2006cited by this paper
• Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.

  2006cited by this paper
• Ago-Allosteric Modulation and Other Types of Allostery in Dimeric 7TM Receptors

  2006cited by this paper
• Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling

  2006cited by this paper
• Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists

  2006cited by this paper
• Divergent mechanisms for allosteric modulators of adenosine A1 receptors

  2006cited by this paper
• Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

  2005cited by this paper
• Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers

  2005cited by this paper
• Principles: a model for the allosteric interactions between ligand binding sites within a dimeric GPCR.

  2005cited by this paper
• The study of G‐protein coupled receptor oligomerization with computational modeling and bioinformatics

  2005cited by this paper
• Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

  2005cited by this paper
• Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation.

  2005cited by this paper
• Dimerization of chemokine receptors and its functional consequences.

  2005cited by this paper
• The impact of G‐protein‐coupled receptor hetero‐oligomerization on function and pharmacology

  2005cited by this paper
• Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

  2005cited by this paper
• Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.

  2005cited by this paper
• A simple mathematical model of cooperativity in receptor mosaics based on the "symmetry rule".

  2005cited by this paper
• Paired Activation of Two Components within Muscarinic M3 Receptor Dimers Is Required for Recruitment of β-Arrestin-1 to the Plasma Membrane*

  2005cited by this paper
• Cooperative Conformational Changes in a G-protein-coupled Receptor Dimer, the Leukotriene B4 Receptor BLT1*

  2004cited by this paper
• The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors

  2004cited by this paper
• The Heptahelical Domain of GABAB2 Is Activated Directly by CGP7930, a Positive Allosteric Modulator of the GABAB Receptor*

  2004cited by this paper
• Negative Cooperativity of Glutamate Binding in the Dimeric Metabotropic Glutamate Receptor Subtype 1*

  2004cited by this paper
• Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.

  2004cited by this paper
• G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling.

  2004cited by this paper
• Roles of G‐protein‐coupled receptor dimerization

  2004cited by this paper
• A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

  2004cited by this paper
• Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor.

  2004cited by this paper
• Chemokine inhibition--why, when, where, which and how?

  2004cited by this paper
• A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.

  2004cited by this paper
• Closed state of both binding domains of homodimeric mGlu receptors is required for full activity

  2004cited by this paper
• GPCR interacting proteins (GIP).

  2004cited by this paper
• A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

  2004cited by this paper
• The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer*

  2003cited by this paper
• GPCR dimerisation.

  2003cited by this paper
• Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes*

  2003cited by this paper
• Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.

  2003cited by this paper
• Atomic-force microscopy: Rhodopsin dimers in native disc membranes

  2003cited by this paper
• Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein.

  2003cited by this paper
• Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer*

  2002cited by this paper
• International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature

  2002cited by this paper
• Receptor Activity-modifying Protein 1 Determines the Species Selectivity of Non-peptide CGRP Receptor Antagonists* 210

  2002cited by this paper
• Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.

  2002cited by this paper
• Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.

  2002cited by this paper
• An amino-acid taste receptor

  2002cited by this paper
• Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer.

  2002cited by this paper
• G Protein-Coupled Receptor Allosterism and Complexing

  2002cited by this paper
• Metal Ion-mediated Agonism and Agonist Enhancement in Melanocortin MC1 and MC4 Receptors*

  2002cited by this paper
• Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function

  2001cited by this paper
• Characterization of Sequence Determinants within the Carboxyl-terminal Domain of Chemokine Receptor CCR5 That Regulate Signaling and Receptor Internalization*

  2001cited by this paper
• Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer

  2001cited by this paper
• Dimerization of G-protein-coupled receptors.

  2001cited by this paper
• Allosteric regulation of CCR5 by guanine nucleotides and HIV-1 envelope.

  2001cited by this paper
• Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation.

  2001cited by this paper
• Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

  2001cited by this paper
• Mammalian sweet taste receptors.

  2001cited by this paper
• Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

  2000cited by this paper
• Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).

  2000cited by this paper
• Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy

  2000cited by this paper
• International union of pharmacology. XXII. Nomenclature for chemokine receptors.

  2000cited by this paper
• Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.

  2000cited by this paper
• Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

  2000cited by this paper
• Role of heteromer formation in GABAB receptor function.

  1999cited by this paper
• G-protein-coupled receptor heterodimerization modulates receptor function

  1999cited by this paper
• Molecular tinkering of G protein‐coupled receptors: an evolutionary success

  1999cited by this paper
• Heterodimerization is required for the formation of a functional GABAB receptor

  1998cited by this paper
• GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

  1998cited by this paper
• GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

  1998cited by this paper
• Domain swapping in G-protein coupled receptor dimers.

  1998cited by this paper
• GABAB-receptor subtypes assemble into functional heteromeric complexes

  1998cited by this paper
• Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling

  1996cited by this paper
• Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

  1996cited by this paper
• RECEPTOR CONFORMATIONAL INDUCTION VERSUS SELECTION : ALL PART OF THE SAME ENERGY LANDSCAPE

  1996cited by this paper
• Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors (*)

  1995cited by this paper
• Allosteric modulation of muscarinic acetylcholine receptors.

  1995cited by this paper
• Reconstitution of functional muscarinic receptors by co‐expression of amino‐ and carboxyl‐terminal receptor fragments

  1993cited by this paper
• Regulation of dopamine D2 receptors by sodium and pH.

  1991cited by this paper
• Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

  1990cited by this paper
• Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis.

  1988cited by this paper
• Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

  1985cited by this paper
• Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

  1981cited by this paper
• A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

  1980cited by this paper
• Contribution of negative cooperativity to the thyrotropin-receptor interaction in normal human thyroid: kinetic evaluation.

  1979cited by this paper
• Opiate receptor: cooperativity of binding observed in brain slices.

  1977cited by this paper
• Cooperative properties of hormone receptors in cell membranes.

  1976cited by this paper
• Cooperative properties of hormone receptors in cell membranes.

  1976cited by this paper
• β-Adrenergic receptors: Evidence for negative cooperativity

  1975cited by this paper
• Beta-adrenergic receptors: evidence for negative cooperativity.

  1975cited by this paper
• Negative co-operativity in clustered receptors as a possible basis for membrane action.

  1974cited by this paper

• G Protein-Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders.

  2025cites this paper
• Immune Cell Activation: Stimulation, Costimulation, and Regulation of Cellular Activation

  2023cites this paper
• Insights into the operational model of agonism of receptor dimers

  2022cites this paper
• Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.

  2022cites this paper
• Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

  2022cites this paper
• Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay

  2020influential citation
• Rearrangement of the transmembrane domain interfaces associated with the activation 1 of a GPCR hetero-oligomer 2 3

  2020cites this paper
• Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry

  2020cites this paper
• GPCR interaction as a possible way for allosteric control between receptors.

  2019cites this paper
• Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

  2019cites this paper
• Defining ligand binding modes of the orphan G protein-coupled receptor GPR84

  2019cites this paper
• Interplay of self-association and conformational flexibility in regulating protein function

  2018cites this paper
• Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth

  2018cites this paper
• Immune Cell Activation: Stimulation, Costimulation, and Regulation of Cellular Activation

  2018cites this paper
• Actin cytoskeleton–dependent regulation of corticotropin-releasing factor receptor heteromers

  2017cites this paper
• Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation.

  2016cites this paper
• Receptor Tyrosine Kinase Signal Transduction and the Molecular Basis of Signalling Specificity

  2015cites this paper
• Untersuchungen zur funktionellen Interaktion zwischen dem Rezeptor Mas und dem AT2-Rezeptor in primären, murinen Astrozyten

  2015cites this paper
• Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling.

  2015cites this paper
• Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

  2015cites this paper
• Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

  2015cites this paper
• Functional characterization of G-protein-coupled receptors: a bioinformatics approach.

  2014cites this paper
• Biochemical features important for D6 function

  2014cites this paper
• Heterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling.

  2013cites this paper
• G-Protein Coupled Receptors Dimerization: Diversity in Somatostatin Receptors Subtypes

  2013cites this paper
• Caged Naloxone Reveals Opioid Signaling Deactivation Kinetics

  2013cites this paper
• Caged Naloxone Reveals Opioid Signaling Deactivation Kinetics s

  2013cites this paper
• Quaternary structure predictions and structural communication features of GPCR dimers.

  2013cites this paper
• Modeling the allosteric modulation of CCR5 function by Maraviroc.

  2013cites this paper
• V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH.

  2012cites this paper
• A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo.

  2012cites this paper
• Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain

  2012cites this paper
• Allosteric interactions within the AT₁ angiotensin receptor homodimer: role of the conserved DRY motif.

  2012cites this paper
• Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors

  2012cites this paper
• Receptores de dopamina y heterómeros de receptores de dopamina en la modulación de la neurotransmisión

  2012cites this paper
• Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems

  2012cites this paper
• Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.

  2012cites this paper
• KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis

  2012cites this paper
• Dimerization of NKp46 Receptor Is Essential for NKp46-Mediated Lysis: Characterization of the Dimerization Site by Epitope Mapping

  2012cites this paper
• G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis

  2012cites this paper
• Update 1 of: computational modeling approaches to structure-function analysis of G protein-coupled receptors.

  2011cites this paper
• Trans‐activation between 7TM domains: implication in heterodimeric GABAB receptor activation

  2011cites this paper
• CODA-RET reveals functional selectivity as a result of GPCR heteromerization

  2011cites this paper
• Effect of clozapine on the dimerization of serotonin 5-HT(2A) receptor and its genetic variant 5-HT(2A)H425Y with dopamine D(2) receptor.

  2011cites this paper
• Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

  2011cites this paper
• Herpesvirus-encoded GPCRs rewire cellular signaling.

  2011cites this paper
• Sweet taste receptor gene variation and aspartame taste in primates and other species.

  2011cites this paper
• Relationship between Homo-oligomerization of a Mammalian Olfactory Receptor and Its Activation State Demonstrated by Bioluminescence Resonance Energy Transfer*

  2011cites this paper
• Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A*

  2011cites this paper
• G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand?

  2011cites this paper
• Allostery in GPCRs: 'MWC' revisited.

  2011cites this paper
• Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

  2011cites this paper
• Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.

  2010cites this paper
• Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.

  2010cites this paper
• An emerging role for kinase screening in GPCR drug discovery.

  2010cites this paper
• Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays

  2010cites this paper
• Structural Basis of Dopamine Receptor Activation

  2010cites this paper
• Receptor‐Mediated G Protein Activation: How, How Many, and Where?

  2010cites this paper
• An in vivo demonstration of functional G protein–coupled receptor dimers

  2010cites this paper
• Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

  2010cites this paper
• Class A GPCR heterodimers: evidence from binding studies.

  2010cites this paper
• GPCR Conformations: Implications for Rational Drug Design

  2010cites this paper
• Direct Interaction of GABAB Receptors with M2 Muscarinic Receptors Enhances Muscarinic Signaling

  2009cites this paper
• Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation

  2009cites this paper
• Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists*

  2009cites this paper
• Chapter 10. Hetero-oligomerization of chemokine receptors.

  2009cites this paper
• Multivalent-based drug design applied to serotonin 5-HT(4) receptor oligomers.

  2009cites this paper
• Bioluminescence Resonance Energy Transfer Studies Reveal Constitutive Dimerization of the Human Lutropin Receptor and a Lack of Correlation between Receptor Activation and the Propensity for Dimerization*

  2009cites this paper
• THEMED ISSUE: GPCR REVIEW G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

  2009cites this paper
• Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

  2009cites this paper
• An Investigation into the pharmacology of the ghrelin receptor

  2009cites this paper
• Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor.

  2009cites this paper
• Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity

  2009cites this paper
• Structural Basis of Allosteric Ligand–Receptor Interactions in the Insulin/Relaxin Peptide Family

  2009cites this paper
• Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration.

  2009cites this paper
• Herpesvirus-Encoded G Protein-Coupled Receptors as Modulators of Cellular Function

  2009cites this paper
• Imaging chemokine receptor dimerization with firefly luciferase complementation

  2009cites this paper
• Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a

  2008cites this paper
• Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1.

  2008influential citation
• The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

  2008cites this paper
• Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2.

  2008cites this paper
• Physiological relevance of GPCR oligomerization and its impact on drug discovery.

  2008cites this paper
• G Protein Activation by the Leukotriene B4 Receptor Dimer

  2008cites this paper
• Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.

  2008cites this paper
• On the fitting of binding data when receptor dimerization is suspected

  2008cites this paper
• Cell surface targeting of μ-δ opioid receptor heterodimers by RTP4

  2008cites this paper
• Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions.

  2008cites this paper
• On a chip demonstration of a functional role for Odorant Binding Protein in the preservation of olfactory receptor activity at high odorant concentration.

  2008cites this paper
• CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

  2008cites this paper
• Modeling the Binding and Function of Metabotropic Glutamate Receptors

  2008cites this paper
• Identification of non-lipid LPA3 antagonists by virtual screening.

  2008cites this paper