SCIENCE@home

In vivo assessment of the durable, green and in situ bio-functional cotton fabrics based carboxymethyl chitosan nanohybrid for wound healing application.

T. Shaheen,Mohamed F Abdelhameed,S. Zaghloul,A. Montaser

Published 2022 in International Journal of Biological Macromolecules

ABSTRACT

Herein, a newly developed approach for durable antibacterial cotton fabrics coated carboxymethyl chitosan (CMCs) via ionic crosslinking driven by cationization of cotton surface (CC) with 3-chloro-2-hydroxyl propyl-trimethyl ammonium chloride (CHTAC). In this regard, the novelty was extended to impart a highly antibacterial activity through harnessing of the as-functionalized CMCs/CC in situ preparation of AgNPs, without using of hazardous reductants. The antibacterial activity of the in situ prepared AgNPs onto CMCs/CC as well as the in vivo study on the rat lab were investigated to evaluate their healing efficiency, pathological tissues and biomarkers. Results affirmed that the treatment of CC with 10% of CMCs was adequate to achieve the highest swelling ratio which, in turns, is able to in situ deposition of AgNPs with a size range of 2-10 nm onto CC/CMCs rendering them a highly durable antibacterial activity against both Gram +Ve and Gram -Ve bacteria, which had a bacterial reduction of 98% to 86% after 20 washing cycles. Furthermore, the in vivo study revealed effectively the advantageous uses of the cotton functionalized with AgNPs compared to CC/CMCs in wound healing via alleviating the oxidative stress and promoting hyaluronic acid in wounded skin as well as increasing RUNX2 in healed skin tissues.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-75 of 75 references · Page 1 of 1

CITED BY

Showing 1-26 of 26 citing papers · Page 1 of 1